Personalized outfit compatibility learning is an emerging yet challenging task. Most of the existing methods focus on general outfit compatibility learning. Although a few works have been proposed ...for personalized fashion compatibility, they either considered user preference on fashion items with specific patterns or design elements or recommended outfits based on the overall visual similarity according to the users’ preferred collections. This paper adopts physical and fashion attributes for effective personalized fashion compatibility evaluation and recommendation. The physical attributes are concluded into seven aspects: body shape, skin color, hairstyle, hair color, height, breast size (breasts), and color contrast. The personalized outfit compatibility problem in this paper is a multi-label classification problem and formulated as an optimization function with outfit images, fashion attributes, and physical attributes as input. It is the first attempt to solve the problem by discovering the correlation between visual image features, fashion attributes, and physical attributes. Specifically, the correlation is learned with two transformer encoders by updating attention weights of different embedding pairs during the training process. The model can not only predict the fashion attributes of the outfit’s top, bottom, shoes, and bag items, but also predict the incompatible physical attributes of an individual towards the given outfit. It can be used to recommend outfits that best fit an individual and the predicted fashion attributes can be used for result explanation. The O4U dataset, which contains rich annotations of fashion item attributes and human physical attributes of the outfits, is used to evaluate the performance of the proposed method. The quantitative and qualitative results show that the proposed method outperforms state-of-the-art methods for personalized outfit compatibility evaluation.
•We first consider individual physical attributes for personalized recommendation.•Correlation between visual features and physical attributes is explored.•Experimental results demonstrate the superiority of the proposed model.
Antagonizing the androgen-receptor (AR) pathway is an effective treatment strategy for patients with metastatic castration-resistant prostate cancer (CRPC). Here, we report the results of a ...first-in-human phase 1/2 study which assessed the safety, pharmacokinetics, and activity of SHR3680 (a novel AR antagonist) in patients with metastatic CRPC.
This phase 1/2 study enrolled patients with progressive metastatic CRPC who had not been previously treated with novel AR-targeted agents. In the phase 1 dose-escalation portion, patients received oral SHR3680 at a starting daily dose of 40 mg, which was subsequently escalated to 80 mg, 160 mg, 240 mg, 360 mg, and 480 mg per day. In phase 2 dose-expansion portion, patients were randomized to receive daily dose of 80 mg, 160 mg, or 240 mg of SHR3680. The primary endpoint in phase 1 was safety and tolerability and in phase 2 was the proportion of patients with a prostate-specific antigen (PSA) response (≥ 50% decrease of PSA level) at week 12.
A total of 197 eligible patients were enrolled and received SHR3680 treatment, including 18 patients in phase 1 and 179 patients in phase 2. No dose-limiting toxicities were reported and the maximum tolerated dose was not reached. Treatment-related adverse events (TRAEs) occurred in 116 (58.9%) patients, with the most common one being proteinuria (13.7%). TRAEs of grade ≥ 3 occurred in only 23 (11.7%) patients, and no treatment-related deaths occurred. Antitumor activities were evident at all doses, including PSA response at week 12 in 134 (68.0%; 95% CI, 61.0-74.5) patients, stabilized bone disease at week 12 in 174 (88.3%; 95% CI, 87.2-95.5) patients, and responses in soft tissue lesions in 21 (34.4%, 95% CI, 22.7-47.7) of 61 patients.
SHR3680 was well tolerated and safe, with promising anti-tumor activity across all doses tested in patients with metastatic CRPC. The dose of 240 mg daily was recommended for further phase 3 study.
Clinical trials.gov NCT02691975; registered February 25, 2016.
In order to cluster the textual data with high dimension in modern data analysis, the spherical
k
-means clustering is presented. It aims to partition the given points with unit length into
k
sets so ...as to minimize the within-cluster sum of cosine dissimilarity. In this paper, we mainly study seeding algorithms for spherical
k
-means clustering, for its special case (with separable sets), as well as for its generalized problem (
α
-spherical
k
-means clustering). About the spherical
k
-means clustering with separable sets, an approximate algorithm with a constant factor is presented. Moreover, it can be generalized to the
α
-spherical separable
k
-means clustering. By slickly constructing a useful function, we also show that the famous seeding algorithms such as
k
-means++ and
k
-means|| for
k
-means problem can be applied directly to solve the
α
-spherical
k
-means clustering. Except for theoretical analysis, the numerical experiment is also included.
Melatonin (MT) regulates reproductive performance as a potent antioxidant; however, its beneficial effects on oocyte development remain largely unknown, especially in human oocytes. The collected 193 ...immature oocytes from the controlled ovarian hyperstimulation (COH) cycle underwent in vitro maturation (IVM) in IVM medium contained 10 μmol/L MT (n = 105, M group) and no MT (n = 88, NM group), followed by insemination and embryo culture. The results showed that the high‐quality blastocyst formation rate in the M group (28.4%) was significantly higher than that in the NM group (2.0%) (P = .0001), and the aneuploidy rate was low (15.8%). In the subsequent clinical trials, three healthy infants were delivered. Next, single‐cell RNA‐seq data revealed 1026 differentially expressed genes (DEGs) between the two groups, KEGG enrichment analysis revealed that the majority of DEGs involved in oxidative phosphorylation pathway, which associated with ATP generation, was upregulated in the M group. Finally, confocal fluorescence staining results revealed that the mitochondrial membrane potential in the oocytes significantly increased and intracellular ROS and Ca2+ levels greatly decreased in the M group. Melatonin can promote the development of immature human oocytes retrieved from the COH cycle into healthy offspring by protecting mitochondrial function.
Online stylist service enjoys huge economic potentials due to the trend of transformation of the fashion industry to digitalisation. Existing works either predict the fashion compatibility from the ...overall aspect or evaluate the compatibility with type-conditional representations. The prediction is hard to interpret due to the abstractive forecast. This paper proposes a visual and semantic representation model for explainable evaluation and recommendation. The model considers fashion compatibility from different factors, such as colour, material and style, by leveraging low to high-level features from former to later layers of CNN. The colour correlation and the pairwise relationship of fashion items in the same outfit are considered during the prediction stage. Instead of just predicting an outfit as compatible or incompatible, the model can classify an outfit as three precise evaluation levels: Good, Normal and Bad. The detailed compatible level is more consistent with the fashion sense of our human brain as Good or Bad outfits may have specific characteristics while Normal outfits tend to be ordinary. Additionally, the model can diagnose and recommend substitutions of the problematic fashion items from overall compatibility or colour-specific aspects by tracking the prediction matrices’ backpropagation gradients during the recommendation stage. Experiments in terms of outfit compatibility prediction and fill in the blank are conducted to evaluate the prediction ability of the proposed model. In contrast, fashion substitution recommendation experiments are conducted to assess the compatibility diagnosis and recommendation ability. Quantitative and qualitative results show that the model enables online stylist services with excellent explainability and generalisation on fashion prediction and recommendation.
•We evaluate outfit’s compatibility more generally with a unified framework.•Outfit’s colour correlation, semantic and visual similarity are jointly considered.•Outfit’s Compatibility can be improved in a reasonable and interpretable way.
This study synthesized UiO-66 (Zr) in situ on wood via a one-step solvothermal method. UiO-66/wood was successfully prepared and its catalytic performance for the ofloxacin (OFX) photodegradation ...under simulate sunlight was also explored. UiO-66/wood exhibited a better catalytic performance, and its degradation rate constant was about 1.2 and 1.5 times than that of UiO-66 and wood, respectively. The effects of solution initial concentration, pH of the system and dosage of the photocatalyst were explored. Additionally, the active species trapping experiments and UV–vis diffused reflectance spectra measurements were conducted to investigated the photocatalytic mechanism of the UiO-66/wood composite, superoxide radical (O2•–) and hydroxyl radical (•OH) were the main reactive species. In addition, the possible degradation pathways of OFX were analyzed by LC-MS. Meanwhile, the UiO-66/wood showed outstanding stability and reusability after 4 cycles experiments. The removal performance of UiO-66/wood towards real samples showed it has potential in actual application .
UiO-66/wood was prepared and its catalytic performance for the ofloxacin (OFX) photodegradation under simulate sunlight was explored. Not only the possible photocatalytic mechanism and degradation pathways of the photocatalytic process were studied, but also the product toxicity was analyzed. Display omitted
Inactivation of glutathione S-transferase pi 1 (GSTP1) via hypermethylation is an early and common event in prostate carcinogenesis. Functional inactivation of GSTP1 increases the susceptibility to ...oxidative stress and enhance progression risk of the prostatic carcinoma. In this study, we hypothesized that the Piwi-interacting RNA (piRNA) could be a sequence-recognition and guidance molecule for induction of promoter methylation of GSTP1 facilitating prostate carcinogenesis. We found that piR-31470 was highly expressed in prostate cancer cells, and piR-31470 could bind to piwi-like RNA-mediated gene silencing 4 (PIWIL4) to form the PIWIL4/piR-31470 complex. This complex could bind to the nascent RNA transcripts of GSTP1, and recruit DNA methyltransferase 1, DNA methyltransferase 3 alpha and methyl-CpG binding domain protein 2 to initiate and maintain the hypermethylation and inactivation of GSTP1. Our data demonstrated that the overexpression of piR-31470 inhibited the levels of GSTP1 and increased vulnerability to oxidative stress and DNA damage in human prostate epithelial RWPE1 cells. In conclusion, this study characterized the roles of the PIWIL4/piR-31470 complex in the regulation of the transcription of GSTP1 by methylating the CpG island of GSTP1. This discovery may provide a novel therapeutic strategy by targeting piRNAs for the epigenetic treatment of prostate cancer.
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•piR-31470 was highly expressed in prostate cancer cells.•piR-31470 could bind to PIWIL4 to form the PIWIL4/piR-31470 complex.•The PIWIL4/piR-31470 complex could recruit DNMT1, DNMT3α and MBD2 to initiate and maintain the hypermethylation of GSTP1.•The inactivation of GSTP1 increased the vulnerability to oxidative stress and promoted proliferation in prostate cells.
A series of new luminescent lanthanide benzoates Ln2(phen)2(bza)4(Ac)2 {Ln = Eu (1), Gd3+(2), Tb3+ (3), Dy3+(4), Tm3+(5); phen = 1,10-phenanthroline, Hbza = benzoic acid, Ac− = acetate)} and ...Ln2(phen)2(bza)4(NO3)2 Ln = Sm3+(6), Eu3+ (7), Tb3+ (8), Dy3+ (9), Tm3+ (10) have been hydrothermally prepared by the usage of the π-conjugated phen ligands as chromophores. 1–5 exhibit binuclear Ln2(phen)2(bza)4(Ac)2 moieties built up from two Ln(phen)3+ groups joined together by the bridging bza− and Ac− ligands, while 6–10 show another binuclear Ln2(phen)2(bza)4(NO3)2 moieties constructed by two Ln(phen)(NO3)2+ groups linked together by the bridging bza− ligands. These compounds offer the rare examples of binuclear lanthanide benzoates decorated by phen chromophores. Luminescent and sensing properties of 1–10 were studied, revealing that europium (1 and 7) and terbium (3 and 8) benzoates can be used as a bifunctional luminescent probe for acetone and Fe3+ with high efficiency and selectivity.
This work offers the only example of luminescent lanthanide benzoates incorporating phen chromophores and small auxiliary π-conjugated NO3− ligands, whose europium benzoate shows good bifunctional sensor targeted for acetone and Fe3+ ion. Display omitted
•A series of new luminescent lanthanide benzoates were hydrothermally prepared.•The Eu3+ and Tb3+ complexes shows bifunctional sensor for acetone and Fe3+ ion.•5–6 offer the rare examples of lanthanide benzoates incorporating phen chromophores.
The propagation properties of a hollow Gaussian beam (HGB) carrying on‐axis and off‐axis vortices through a high numerical aperture lens are investigated. The intensity of the focused beam in the ...focal plane can be controlled by choosing the different topological charges, the beam order, and the semi‐aperture angle. As intrinsic properties, vortex beams possess both spin and orbital angular momenta. The spin angular momenta (SAM) density can be treated as a vector in 3D since it exists in arbitrary orientation during the beam propagation. The vectors of SAM density orientation of the focused beam in 3D rotate around the central axis whose locations mainly rely on the vortices. The magnitude of the SAM density near the focus plane abruptly varies by altering the focal length of the lens. Under tightly focusing condition, two new pairs of vortices generate alternately on x and y axes in the vectorial electric fields, while the topological charges increase by one.
Propagation properties of a hollow Gaussian beam carrying on‐axis and off‐axis vortices through a high numerical aperture lens are investigated. The magnitude of the spin density near the focus abruptly varies by altering the focal length of the lens. Additionally, two new pairs of vortices generate alternately in the vectorial electric fields while the topological charges increase by one.
Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. ...Patients are diagnosed with tRCC usually before 45 years of age with poor prognosis. We investigated this disease using two tRCC cell lines, UOK109 and UOK120, in this study.
The purpose of this study was to investigate the pathogenic mechanism of TFE3 fusions in tRCC based on its subcellular localization, nuclear translocation and transcriptional activity. The expression of TFE3 fusions and other related genes were analyzed by quantitative reverse transcription PCR (qRT-PCR) and Western blot. The subcellular localization of TFE3 was determined using immunofluorescence. The transcriptional activity of TFE3 fusions was measured using a luciferase reporter assay and ChIP analysis. In some experiments, TFE3 fusions were depleted by RNAi or gene knockdown. The TFE3 fusion segments were cloned into a plasmid expression system for expression in cells.
Our results demonstrated that TFE3 fusions were overexpressed in tRCC with a strong nuclear retention irrespective of treatment with an mTORC1 inhibitor or not. TFE3 fusions lost its co-localization with lysosomal proteins and decreased its interaction with the chaperone 14-3-3 proteins in UOK109 and UOK120 cells. However, the fusion segments of TFE3 could not translocate to the nucleus and inhibition of Gsk3β could increase the cytoplasmic retention of TFE3 fusions. Both the luciferase reporter assay and ChIP analysis demonstrated that TFE3 fusions could bind to the promoters of the target genes as a wild-type TFE3 protein. Knockdown of TFE3 results in decreased expression of those genes responsible for lysosomal biogenesis and other target genes. The ChIP-seq data further verified that, in addition to lysosomal genes, TFE3 fusions could regulate genes involved in cellular responses to hypoxic stress and transcription.
Our results indicated that the overexpressed TFE3 fusions were capable of escaping from the control by the mTOR signaling pathway and were accumulated in the nucleus in UOK109 and UOK120 cells. The nuclear retention of TFE3 fusions promoted the expression of lysosomal genes and other target genes, facilitating cancer cell resistance against an extreme environment.
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