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zadetkov: 683
31.
  • Perspectives and limitation... Perspectives and limitations for nucleo(t)side analogs in future HBV therapies
    Levrero, Massimo; Subic, Miroslava; Villeret, Francois ... Current opinion in virology, June 2018, 2018-06-00, 20180601, 2018-06, Letnik: 30
    Journal Article
    Recenzirano

    •NAs will be an important component of the first new combinations to be tested in clinical trials.•Add on in NA-suppressed patients, pretreatment with NAs (sequential combination) or combination with ...
Celotno besedilo
32.
  • Co-Transcriptional Regulati... Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters
    Giraud, Guillaume; El Achi, Khadija; Zoulim, Fabien ... Viruses, 04/2024, Letnik: 16, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot ...
Celotno besedilo
33.
  • Selection of chronic hepati... Selection of chronic hepatitis B therapy with high barrier to resistance
    Gish, Robert, Prof; Jia, Ji-Dong, MD; Locarnini, Stephen, Prof ... The Lancet infectious diseases, 04/2012, Letnik: 12, Številka: 4
    Journal Article
    Recenzirano

    Summary Antiviral drug resistance is a crucial factor that frequently determines the success of long-term therapy for chronic hepatitis B. The development of resistance to nucleos(t)ide analogues has ...
Celotno besedilo
34.
  • Toll-like receptor 7 agonis... Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism
    Niu, Congrong; Li, Li; Daffis, Stephane ... Journal of hepatology, 05/2018, Letnik: 68, Številka: 5
    Journal Article
    Recenzirano
    Odprti dostop

    Display omitted •GS-9620 has no direct antiviral activity against HBV.•Type I IFN induced by GS-9620 durably suppresses HBV without reducing cccDNA levels.•GS-9620-induced cytokines enhance HBV ...
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35.
  • Guidance for Design and End... Guidance for Design and Endpoints of Clinical Trials in Chronic Hepatitis B—Report From the 2019 EASL‐AASLD HBV Treatment Endpoints Conference
    Cornberg, Markus; Lok, Anna Suk‐Fong; Terrault, Norah A. ... Hepatology, March 2020, Letnik: 71, Številka: 3
    Journal Article
    Recenzirano
    Odprti dostop

    Representatives from academia, industry, regulatory agencies, and patient groups convened in March 2019 with the primary goal of developing agreement on chronic hepatitis B virus (HBV) treatment ...
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36.
  • Gene Editing Technologies t... Gene Editing Technologies to Target HBV cccDNA
    Martinez, Maria Guadalupe; Smekalova, Elena; Combe, Emmanuel ... Viruses, 11/2022, Letnik: 14, Številka: 12
    Journal Article
    Recenzirano
    Odprti dostop

    Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma. ...
Celotno besedilo
37.
  • New challenges in viral hepatitis
    Thomas, David; Zoulim, Fabien Gut, 05/2012, Letnik: 61 Suppl 1
    Journal Article
    Recenzirano

    Over the past few decades there has been remarkable progress in viral hepatitis. Beginning with discovery of the viral agents, we now have reliable methods to diagnose and monitor all hepatitis virus ...
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38.
  • Control of hepatitis B viru... Control of hepatitis B virus replication by innate response of HepaRG cells
    Lucifora, Julie; Durantel, David; Testoni, Barbara ... Hepatology, January 2010, Letnik: 51, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Hepatitis B virus (HBV) is currently viewed as a stealth virus that does not elicit innate immunity in vivo. This assumption has not yet been challenged in vitro because of the lack of a relevant ...
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39.
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40.
  • Hepatitis B Virus Resistanc... Hepatitis B Virus Resistance to Nucleos(t)ide Analogues
    Zoulim, Fabien; Locarnini, Stephen Gastroenterology, 11/2009, Letnik: 137, Številka: 5
    Journal Article
    Recenzirano
    Odprti dostop

    Patients with chronic hepatitis B (CHB) can be successfully treated using nucleos(t)ide analogs (NA), but drug-resistant hepatitis B virus (HBV) mutants frequently arise, leading to treatment failure ...
Celotno besedilo
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zadetkov: 683

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