Regional brain blood flow was determined in 23 awake, unparalyzed gerbils with a simplified indicator-fractionation technique. The use of intravenous 14C-butanol, an indicator that is freely ...diffusible into the brain, eliminated the need for repetitive sampling of arterial and cerebral venous blood and reduced the period of indicator circulation of 10 seconds. Gerbils spontaneously breathing room air (PaCO2 = 32 +/- 1 (SE) mm Hg) had blood flows in whole cerebrum, cerebellum, and brainstem of 102 +/- 4, 93 +/- 5, and 114 +/- 6 ml/100 gm/min respectively. Cerebral blood flow increased linearly with elevations in PaCO2 (r=0.969) and averaged 3.14 +/- 0.17 ml/100gm/min per mm Hg increase in PaCO2. Interpolated cerebral blood flow at a PaCO2 of 40 mm Hg was 127 +/- 2 ml/100 gm/min. This technique is easy and convenient to use, involves no intracranial surgery, requires steady state conditions for only 10 seconds, and minimizes blood loss in small animals. In more discrete brain regions a less volatile indicator is needed.
The Kilo-Degree Survey (KiDS) is an optical wide-field imaging survey carried out with the VLT Survey Telescope and the OmegaCAM camera. KiDS will image 1500 square degrees in four filters (ugri), ...and together with its near-infrared counterpart VIKING will produce deep photometry in nine bands. Designed for weak lensing shape and photometric redshift measurements, the core science driver of the survey is mapping the large-scale matter distribution in the Universe back to a redshift of ~0.5. Secondary science cases are manifold, covering topics such as galaxy evolution, Milky Way structure, and the detection of high-redshift clusters and quasars. KiDS is an ESO Public Survey and dedicated to serving the astronomical community with high-quality data products derived from the survey data, as well as with calibration data. Public data releases will be made on a yearly basis, the first two of which are presented here. For a total of 148 survey tiles (~160 sq.deg.) astrometrically and photometrically calibrated, coadded ugri images have been released, accompanied by weight maps, masks, source lists, and a multi-band source catalog. A dedicated pipeline and data management system based on the Astro-WISE software system, combined with newly developed masking and source classification software, is used for the data production of the data products described here. The achieved data quality and early science projects based on the data products in the first two data releases are reviewed in order to validate the survey data. Early scientific results include the detection of nine high-z QSOs, fifteen candidate strong gravitational lenses, high-quality photometric redshifts and galaxy structural parameters for hundreds of thousands of galaxies. (Abridged)
Cerebral blood flow (CBF) was assessed with radioactive butanol and antipyrine during and after 1 hour of unilateral carotid artery occlusion in gerbils. Animals with clinical evidence of stroke ...demonstrated a marked fall in ipsilateral CBF during occlusion "no-reflow" phenomenon did not develop; instead, blood flow returned to normal 5 minutes after the termination of carotid occlusion. Flow subsequently fell to half the control value, however, and remained depressed for several hours despite local metabolic demands. This delayed imbalance in energy supply and demand creates a potential for additional brain damage that might be prevented by appropriate therapeutic intervention.
Cerebral blood flow (CBF) techniques based on the principle of indicator fractionation rely upon free diffusibility of the blood flow indicator into brain (i.e. complete cerebral extraction). ...Extraction of two commonly-used indicators, iodoantipyrine and n-butanol, was evaluated in rats by measuring torcular venous efflux after systemic injection of the indicator under conditions of normal and high CBF. The extraction of n-butanol was found to be virtually complete at all blood flows examined; iodoantipyrine, on the other hand, was completely extracted only at flows under 180 ml/100 g/min, despite the fact that the oil: water partition coefficient for iodoantipyrine exceeds that for n-butanol. Brain uptake indices for the two indicators were also measured: brain uptake of n-butanol was greater than that of iodoantipyrine, and the difference was more marked if the indicator entered brain mixed with blood than if it entered as a bloodless bolus. Blood components may thus interact with iodoantipyrine to retard its movement across the blood-brain barrier and thereby limit extraction of this lipid-soluble substance. Inasmuch as iodoantipyrine is diffusion-limited at blood flows above 180 ml/100 g/min, butanol is a more accurate CBF indicator above the normal flow range in the rat.
A patient with medulloblastoma of the cerebellum developed dyspnea and hypoxemia. Pulmonary function tests showed decreased lung volume and diffusing capacity, while the chest radiographs initially ...showed only mild interstitial infiltrates. Repeated gallium scans showed diffuse lung uptake and diagnosis of pulmonary alveolar proteinosis was made by open lung biopsy.
A behaviour modification programme for the treatment of obesity was offered to a population of obese women, aged 51-67, being screened for breast cancer. The programme was offered in two forms: (1) A ...series of ten small group sessions under the guidance of a non-medical leader, with three follow-up meetings after the course (10 S programme). (2). A series of ten mailed lessons with a pre- and post-course interview and three follow-up meetings after the course (10 L programme). The drop-out rate during the course was 12 per cent for the 10 S programme and 37 per cent for the 10 L programme. Follow-up in the 10 S programme revealed an average weight loss of 5.2 kg after 3 months, 4.1 kg after 17 months, and 3.0 kg after 36 months. Comparable figures in the 10 L programme were 3.0 kg, 3.0 kg and 1.6 kg, respectively. Percentile distributions of weight loss after these intervals are presented. Results are compared with those in other obese women in the cancer screening programme who either had no plans for weight reduction or said they had opted for other kinds of intervention. These comparisons clearly favour the behaviour treatment programme, but the picture may have been influenced by a possibly higher motivation of those who followed the course.
White-centered retinal hemorrhages (so-called "Roth spots") were seen in an 11-year-old girl with spontaneous intraventricular and subarachnoid hemorrhage from a ruptured "berry" aneurysm without ...underlying systemic disorder.
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