The history and methods of membrane protein crystallization are described. The solution of the structure of the photosynthetic reaction center from the bacterium Rhodopseudomonas viridis is ...described, and the structure of this membrane protein complex is correlated with its function as a light-driven electron pump across the photosynthetic membrane. Conclusions about the structure of the photosystem II reaction center from plants are drawn, and aspects of membrane protein structure are discussed.
Harold Bloom surveys with majestic view the
literature of the West from the Old Testament to Samuel Beckett. He
provocatively rereads the Yahwist (or J) writer, Jeremiah, Job,
Jonah, the Iliad , the ...Aeneid , Dante's Divine
Comedy , Hamlet , King Lear , Othello ,
the Henry IV plays, Paradise Lost , Blake's
Milton , Wordsworth's Prelude , and works by Freud,
Kafka, and Beckett. In so doing, he uncovers the truth that all our
attempts to call any strong work more sacred than another are
merely political and social formulations. This is criticism at its
best.
Mimicking Photosynthesis Gust, Devens; Moore, Thomas A.
Science (American Association for the Advancement of Science),
04/1989, Letnik:
244, Številka:
4900
Journal Article
Recenzirano
Although the concept of an artificial photosynthetic reaction center that mimics natural electron- and energytransfer processes is an old one, in recent years major advances have occurred. In this ...review, some relatively simple molecular dyads that mimic certain aspects of photosynthetic electron transfer and singlet or triplet energy transfer are described. Dyads of this type have proven to be extremely useful for elucidating basic photochemical principles. In addition, their limitations, particularly in the area of temporal stabilization of electronic charge separation, have inspired the development of much more complex multicomponent molecular devices. The use of the basic principles of photoinitiated electron transfer to engineer desirable properties into the more complex species is exemplified. The multiple electrontransfer pathways available with these molecules make it possible to fine-tune the systems in ways that are impossible with simpler molecules. The study of these devices not only contributes to our understanding of natural photosynthesis, but also aids in the design of artificial solar energy harvesting systems and provides an entry into the nascent field of molecular electronics.
Postmodernist Fiction McHale, Brian
Routledge eBooks,
1987, 20030902, 2004-06-19, 2003-09-02
eBook, Book
Odprti dostop
In this trenchant and lively study Brian McHale undertakes to construct a version of postmodernist fiction which encompasses forms as wide-ranging as North American metafiction, Latin American magic ...realism, the French New New Novel, concrete prose and science fiction. Considering a variety of theoretical approaches including those of Ingarden, Eco, Dolezel, Pavel, and Hrushovski, McHale shows that the common denominator is postmodernist fiction's ability to thrust its own ontological status into the foreground and to raise questions about the world (or worlds) in which we live. Exploiting various theoretical approaches to literary ontology - those of Ingarden, Eco, Dolezel, Pavel, Hrushovski and others - and ranging widely over contemporary world literature, McHale assembles a comprehensive repertoire of postmodernist fiction's strategies of world-making and -unmaking.
Mycosis fungoides is a T-cell lymphoma that arises in the skin and progresses at highly variable rates. Nonradomized studies have suggested that early aggressive therapy may improve the prognosis in ...this usually fatal disease. We studied 103 patients with mycosis fungoides, who, after complete staging, were randomly assigned to receive either combination therapy, consisting of 3000 cGy of electron-beam radiation to the skin combined with parenteral chemotherapy with cyclophosphamide, doxorubicin, etoposide, and vincristine (n = 52) or sequential topical treatment (n = 51). The prognostic factors were well balanced in the two groups. Combined therapy produced considerable toxicity: 12 patients required hospitalization for fever and transient neutropenia, 5 had congestive heart failure, and 2 were later found to have acute nonlymphocytic leukemia. Patients receiving combined therapy had a significantly higher rate of complete response, documented by biopsy, than patients receiving conservative therapy (38 percent vs. 18 percent; P = 0.032). After a median follow-up of 75 months, however, there was no significant difference between the treatment groups in disease-free or overall survival. We conclude that early aggressive therapy with radiation and chemotherapy does not improve the prognosis for patients with mycosis fungoides as compared with conservative treatment beginning with sequential topical therapies.
