U radu je na određen način predstavljena spoljna politika DejtonskeBosne i Hercegovine. Njenu osnovu čini Ustav BiH i odrednice koje definišu aktere ukreiranju i sprovođenju spoljne politike Bosne i ...Hercegovine. Pored toga, značajan diorada posvećen je diplomatsko-konzularnoj mreži (DKP) sa osvrtom na njene nedostatkei moguće transformacije kako bi obezbijedilo efikasnije provođenje spoljne politikeBiH, definisane na osnovama konsenzusa predstavnika dva entiteta i tri konstitutivnanaroda. Kroz prizmu dvogodišnjeg nestalnog članstva Bosne i Hercegovine u Savjetubezbjednosti Ujedinjenih nacija predstavljeni su konkretni problemi u provođenjuspoljne politike BiH koji negativno utiču, kako na unutrašnjopolitičke odnose u BiH,tako i na stvaranje negativnog imidža BiH u međunarodnim odnosima. Na kraju su, naodređen način predstavljeni pravci cjelovitog definisanja spoljne politke BiH, kao iorganizacije sistema DKP mreže u skladu sa specifičnostima uređenja BiH.
Prometnice u Republici Hrvatskoj ne mogu se gledati izvan konteksta prometnica Europ¬ske unije budući da se nalaze na prometnim koridorima koji su značajni za tranzit roba i usluga Europske unije. ...Našim teritorijem prevozi se velika količina roba od koje opasne robe čine gotovo četvrtinu ukupno prevezene robe. Nesreće u okolišu svojim intenzitetom i dugotrajnim posljedicama utječu na kvalitetu življenja. Pravnom regulativom od strane Republike Hrvatske pokušavaju se što kvalitetnije definirati zakonski uvjeti odvijanja prometa i sigurnosti u prometu. Ovim člankom pokušava se skrenuti pozornost na stanje u prometu i probleme koj i mogu nastupiti kao rezultat nesreća.
The effects of nine intra- and extracellular proteinases and six proteinase inhibitors on the repair of potentially lethal damage (PLDR) induced by gamma-rays in plateau-phase V79 cells were ...examined. It was demonstrated that these agents, which are intrinsic factors produced within mammalian cells, can modify PLDR activity. A stimulatory effect on PLDR was seen with calf liver neutral proteinase, and to a lesser extent, with inhibitor pepstatin A. Other proteinases which belong to serine, cysteine and aspartic superfamilies, as well as proteinase inhibitors, inhibited PLDR to different degrees. The effects of some of these agents, present during the PLDR period, on the rate of tritiated thymidine incorporation into the acid-insoluble cell fraction was also examined. They can modify the DNA synthesis of cells when subcultured from plateau phase for the assessment of colony-forming ability. There is no clear evidence that the effects observed are entirely attributed to the alteration of cellular proliferative processes. It seems more likely that many serine and cysteine proteinases and their inhibitors can adversely affect the PLDR process by modulating the activity of proteinase(s) and other enzymes involved more directly in PLDR because of interrelationships of the entire intracellular proteinase system.
Dependence of the nucleoside effect on linear energy transfer Ferle-Vidović, A; Petrović, D; Sorić, J ...
International journal of radiation biology and related studies in physics, chemistry and medicine,
01/1979, Letnik:
36, Številka:
2
Journal Article
Recenzirano
L929 cells were irradiated by cyclotron-produced neutrons and by 14.8 MeV monoenergetic neutrons. For comparison cells were also irradiated by 60Co gamma rays. Following irradiation cells were ...treated by an equimolar solution of deoxyribonucleosides, and the effect on cell survival measured. Results show that nucleoside treatment was efficient after low-LET irradiation: gamma ray survival curves were altered by deoxyribonucleosides in terms of significantly increased extrapolation numbers only, but without Do change. Cells irradiated by neutrons from either of the two sources did not respond to nucleoside treatment, and consequently their survival curves remained unaltered. These results show that the nucleoside effect does occur after low-LET irradiation, but apparently not following high-LET irradiation. Since deoxyribonucleosides as well as other cell breakdown products are released in irradiated and necrotic tumours due to massive cell destruction, such a nucleoside effect could possibly enhance the cell survival and thus effect the result of radiotherapy. Absence of the nucleoside effect in case of high-LET irradiation may therefore be an additional potential gain from neutrons in radiotherapy.
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