Effects of centrally applied vasopressin on the pituitary ACTH cells in male rats Nesic, D.M.(University of Belgrade, Belgrade (Serbia and Montenegro). School of Medicine, Institute of Physiology) E-mail:drdejannesic@yahoo.com; Stevanovic, D.M; Ajdzanovic, V.Z ...
Iugoslavica Physiologica et Pharmacologica Acta (Serbia and Montenegro),
(2005), Letnik:
41, Številka:
2
Journal Article
As a conclusion of this study, the results obtained indicate that i.c.v. applied AVP (arginine vasopressin) have significant stimulatory effect on growth of pituitary ACTH cells in adult male rats.
Cadmium (Cd+2) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the blood. Wistar albino rats (3 months old), were injected with a ...single dose of CdCl2 (0.4 mg Cd/kg i.p. and sacrificed after 24 h). The hematological parameters: red blood cells count (RBCs), hematocrite (Ht) value and hemoglobin (Hb) concentration were significantly decreased in the blood of Cd treated rats. The activities of enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in plasma, as well as concentration of blood glucose were significantly increased in animals treated with cadmium in comparison to control values. The treatment with Cd increased lipid peroxidation (LP) and reduced glutathione (GSH) contents in the blood, suggesting that the Cd induced oxidative stress. These results of the study suggested that Cd induced alterations in hemato-biochemical parameters and LP and GSH content.
In this study protective effect of a nimesulide (NM), N-acethylcysteine (NAC; Fluimucil(R)) and their combinations on pathohistological changes in the heart of rats poisoned with T-2 toxin (T-2), one ...of the most cytotoxic trichothecene mycotoxin was examinated. Experiments were carried out in adult female Wister rats weighing 200-250 g. Based on the results obtained, it can be concluded that nimesulide exerts a significant protective influence on T-2 toxin induced pathohistological changes in heart of rats
Phenotypic changes of macrophages, interdigitating (ID) cells and mesenchymal stroma of the thymus were studied in male Wispar rats subjected to radioprotector WR-638 (358 mg+AFw-kg b.w. ip) and/or ...whole body X-ray irradiation 15 days after their application. They were identified in situ on cryostat thymic sections using immunoperoxidase staining by a R-MC 23, R-MC 39, R-MC 41, R-MC 44, R-MC 45, ED1, ED2 and OX 39 monoclonal antibodies (mAbs). It was shown that WR-638 protected rat thymus from ionising radiation effects, preferentially as a result of lymphoid compartment preservation. However, radioprotector also caused changes in the number and phenotypic characteristics of macrophages and ID cells in irradiated rat thymus. WR-638 prominently reduced changes caused by radiation in vascular structures of the thymus, too. This influence of WR-638 on thymic microenvironment elements probably contribute to its beneficial radioprotectove effect on the irradiated rat thymus
The goal of this study was to evaluate the antidotal potencies of a nimesulide (NM, 30 mg/kg im), N-acethylcysteine (NAC, Fluimucil(R) 200 mg/kg ip) and their combinations in animals intoxicated with ...1.0 LD50 (0.18 mg/kg sc) of trichothecene mycotoxin T-2 toxin (T-2). Their antidotal efficacy was investigated by monitoring their effects on general condition, 24-hour survival, body weight gain, food and water consumption changes in rats acutely poisoned with T-2 during a 4-week period. Experiments were performed in adult female Wister rats weighing 200-250 g. The results obtained show that NM, as a well-known selective COX-2 inhibitor, affords a significant antidotal effect against acute T-2 mycotoxicosis in rats
Antioxidant effect of coenzyme Q10 in blood from cadmium-exposed rats Ognjanovic, B. (University of Kragujevac, Kragujevac (Serbia and Montenegro). Faculty of Sciences, Institute of Biology); Maletic, S; Zikic, R ...
Iugoslavica Physiologica et Pharmacologica Acta (Serbia and Montenegro),
(2004), Letnik:
40, Številka:
1-3
Journal Article
It can be concluded from presented results that cadmium induced oxidative damage in erythrocytes leads to anaemia, loss of membrane function by enhancing of LP concentration as well as alteration of ...endogeneous antioxidant components (GSH, ascorbic acid and vitamin E). Our results show that CoQ10 expossed protective role against toxic influence of Cd on all examined parameters in rat blood.
We studied the effect of nonionic detergent Tween 80 in extraction buffer on the activity and isoenzyme pattern of peroxidase from omorika needles. The activity of soluble peroxidases was studied ...using UV-VIS spectrophotometry and isoelectrofocusing. Soluble fraction obtained using extraction buffer with detergent had a higher activity and more isoenzymes in IEF pattern in comparison with the corresponding extract not including detergent in extraction medium.
The paper presents the preliminary results of the study on environmental and health effects due to the use of depleted uranium (DU) ammunition during NATO bombing of Yugoslavia in 1999. The blood ...samples of sheep were collected randomly in the region of Bujanovac, in 2003. To access the possible effects of DU on animal health, some of the relevant biochemical and hematological blood parameters were analyzed: concentration of RBC MDA (red blood cells malondialdehide), erythrocytes superoxide dismutase (SOD) activity, hemoglobin concentration and number of erythrocytes (Er). Functional activity of leucocytes (Le) was performed using NBT reduction and adhesion test. The results are considered in correlation with the data on the content of DU that entered the environment during the bombing. The obtained results on peripheral blood hematological and biochemical parameters indicated that animals were under violent oxidative stress. However, there were not enough data, especially on the content of DU in the environmental samples in the region (soils, vegetation, feed) to enable a conclusive correlation of the blood data with the effects of DU.
