Les premiers poèmes épiques en langue espagnole parurent en 1555, de la plume d’auteurs valenciens ; tout en chantant la victoire des Espagnols sur les Français à Roncevaux et de Bernard del Carpio ...sur le paladin Roland, ils regorgent d’allusions aux mécènes valenciens et en montrent la puissance. Le recours au genre épique n’est-il pas justifié par l’articulation problématique des dimensions locale et nationale ? Le présent article analyse la réflexion qui s’y tient sur la place de Valence au sein de la monarchie à la veille de la mort de Charles-Quint.
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The A1555G mutation in the mitochondrial 12S ribosomal RNA gene is often found in patients with hearing loss after aminoglycoside exposure. A second pathogenic mutation in this gene, deletion of ...thymidine at position 961 with varying numbers of cytosines inserted (delT961Cn), has recently been found to predispose patients to aminoglycoside-induced deafness. We report on a Japanese patient bearing the delT961Cn who had streptomycin-induced deafness. Our report suggests that the delT961Cn plays an important secondary role in the pathogenesis of deafness caused by aminoglycosides. The combination of taking family histories and molecular screening at the 1555 and 961 positions is thought to reduce the frequency of tragic irreversible deafness due to aminoglycosides.
More Iberian discoveries Knighton, Tess
Early Music,
05/2006, Letnik:
34, Številka:
2
Journal Article, Book Review
Recenzirano
Knighton reviews eight CDs of religious music dating from about 1500 to the 18th century, from Spanish- and Portuguese-speaking lands. Among the CDs reviewed are Alonso Lobo: Missa o rex gloriae by ...David Trendell and the Choir of King's College of London and Sebastian de Vivanco, also by the Choir of King's College of London.
English discusses how a thorough search of late 19th-century Sotheby sale catalogues, undertaken for quite different purposes, has unearthed some references to autographs of extreme rarity. The ...autographs themselves have not been found, but they include John Skelton, David Lyndsay, and Thomas More.
To ascertain whether other variations coexist with 1555(A--> G) mutation in the mitochondrial DNA and may aggravate the severity of hearing loss or increase the penetrance of 1555(A--> G) mutation in ...a large family with maternally inherited nonsyndromic deafness in Huaiyin, Jiangsu province.
PCR-restriction fragment length polymorphism (PCR-RFLP) was used to screen both the nt1555 and the nt7445 of the mitochondrial DNA from 27 maternal members in the core family; and then the mitochondrial genomes from two maternal members, and the 12S rRNA genes MTRNR1 and tRNA-Ser(UCN) gene MTTS1 from the others, were amplified by PCR-RFLP and were sequenced.
1555(A--> G) mutation in the mitochondrial DNA was reverified to be one of the major factors which cause maternally inherited nonsyndromic deafness and the cosegregation of 955-960(insC) and 1555(A--> G) was present in this family. Moreover, 7449 (insG), a novel homoplasmic mutation in the tRNA-Ser(UCN) gene, was found to co-exist with 1555(A--> G) mutation in two maternal members.
The cosegregation of 955-960(insC) and 1555(A--> G) implies that 955-960(insC) may synergistically cause hearing loss in the presence of an 1555(A--> G) mutation, serving as an aggravating factor to enhance the sensitivity to aminoglycosides, and may sometimes increase the penetrance of 1555(A--> G) mutation.
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