U Dubašnici, u mjestu Sveti Anton, na pročelju crkve na dva prozora i jednom portalu sačuvalo se čak šest glagoljskih natpisa i grafita. Na portalu je arapskim brojkama zapisan broj „1555“, koji ...najvjerojatnije označava godinu nekog značajnog događaja za to selo. Ostali natpisi i grafiti pružaju nam saznanja o dobročiniteljima, svećenicima naučiteljima i mladićima koji su pohađali glagoljaške škole tijekom XVIII. stoljeća.
Perception deafness caused by the mitochondrial 1555 A>G mutation has been observed frequently in Japan. Recent studies indicate that patient having this 1555 mutation is more likely to be ...suseptaible to aminoglycoside antibiotics. Therefore, if the presence of 1555 mutation can be detected, administration of aminoglycoside antibiotics can be prevented. This genetic examination to detect 1555 mutation could be one of the most significant items in personalized medicine. We have developed a qualitative assay to detect 1555 mutation using Invader system. While 1555 mutations were assumed to be all homoplasmic, recent studies have indicated that heteroplasmy exist among 1555 mutation. Using PCR-RFLP, Abe et al reported that two out of 341 congenital deafness patients examined were heteroplasmic. In order to examine the heteroplasmy in detail, we have modified the current qualitative Invader Assay system for detection of 1555 mutation to be a more quantitative system to detect heteroplasmy. Standard curve was generated from serial dilutions of wild and mutant type plasmids by measuring the fluorescence signal for conversion to quantitative coefficient.The copy number of mutant and wild type plasmids were determined by substitution of quantitative coefficient to the standard curve. The amount of mutant type was expressed as % heteroplasmy against total mitochondrial DNA While results from PCR-RFLP were 5% and 95% heteroplasmy, the quantitative Invader Assay presented 2% and 91% heteroplasmy. Accuracy and reproducibility has been verified. This quantitative Invader Assay may become useful tool in determining the relationship between the amount of heteroplasmy and clinical manifestation.
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Ægtefælle: Lykke, Karen (d. 1562)- All metadata published by Europeana are available free of restriction under the Creative Commons ...CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Imaging and long-slit spectroscopy of the nebula surrounding the WC 11 star IRAS 17514–1555 are presented that allow, for the first time, the nebula to be studied without contamination from the ...underlying star. These data show that the nebula is photoionized and does not appear to have an obvious scattering component. The nebula consists of two shells: a low-density outer region (diameter 18 arcsec) where $ n_\text e \sim 50 \text {cm}^{-3}$, and an unresolved inner nebula (diameter <1.5 arcsec) where $ n_\text e \gt 2 \times 10^4 \text {cm}^{-3}$. The N, O and S abundances derived for the outer nebula seem typical of PNe but it is likely that He is enhanced. Simple modelling suggests that the nebula is kept in thermal equilibrium by a 20 000–22 000 K central star.
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
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