Kilian Muñiz (1970–2020) Streuff, Jan; Echavarren, Antonio M.; González, José Manuel ...
Angewandte Chemie International Edition,
May 11, 2020, Letnik:
59, Številka:
20
Journal Article
Recenzirano
Kilian Muñiz passed away unexpectedly on March 16th, 2020, at the age of only 49. Kilian was a leading figure in the field of catalytic (di‐)amination reactions. He will be remembered as one of the ...finest, most passionate chemists, a dear colleague, and, most of all, as a close friend.
The inside cover picture is an artistic illustration of the bifunctional activation of the phosphite and the iminochromene by a chiral squaramide tattooed on the arm of a chemist. Both substrates ...undergo the phospha‐Michael reaction described in the original article, enabling the chemist to have in hand enantioenriched chromenylphosphonates, an interesting family of bioactive compounds. The cover design is by I. G. Sonsona. Details can be found in the communication by Marqués‐López and Herrera and co‐workers (E. Marqués‐López, I. G. Sonsona, M. Garcés‐Marín, M. C. Gimeno, R. P. Herrera, Adv. Synth. Catal. 2023, 365, 3234–3240; DOI: 10.1002/adsc.202300563)
Catalytic approach could eliminate CO
2
emissions from the key step in making fertilizer.
Nitrogen is essential for all life. But even though nitrogen makes up 78% of the atmosphere, it's in a form ...that can't be used by living organisms. Instead it's tied up in nitrogen molecules made up of two nitrogen atoms that share a strong triple bond that's not easily broken. A century ago, two German chemists, Fritz Haber and Carl Bosch, figured out how to sever those bonds with high pressures and temperatures and weld nitrogen atoms with hydrogens to make ammonia, thereby converting nitrogen into the starting material for a nitrogen-rich fertilizer that can be taken up and used by microbes, plants, and people. That process has been so successful that ammonia-based fertilizers now enable farmers to feed billions more people than our planet could otherwise support. But ammonia production also comes at a high environmental cost, as it is responsible for 2% of worldwide energy use and thus a massive greenhouse gas footprint. However, on page
637
of this issue, U.S. chemists report that they've come up with a way to synthesize ammonia from air, water, and sunlight. If the approach can be scaled up, it could offer a means for making an essential commodity without a major cost to the climate.
Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are ...solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with 'direct' comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.
Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. This perspective explores what more it can offer, aside from the clear benefit of reduced solvent consumption.
Bicyclo1.1.1pentanes (BCP's) have been applied in medicinal chemistry as bioisosteres for phenyl groups. In pursuit of novel BCP analogs, we reported the first synthesis of ...2,2‐difluorobicyclo1.1.1pentanes (BCP–F2) in 2019. Herein, we detail the extension of our effort in the synthesis of BCP‐F2 analogs.
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