RESUMEN: El artículo indaga acerca de las circunstancias históricas, editoriales y literarias que propiciaron la elaboración de una versión ‘pastoril’ de El Abencerraje para su interpolación al final ...del libro IV de La Diana de Jorge de Montemayor. Tras analizar la incorporación del relato morisco a la secuencia editorial del texto pastoril, su génesis literaria, los mecanismos de composición y su función en la estructura de La Diana, el trabajo ofrece una hipótesis razonada acerca de lo sucedido que justificaría la preparación de una nueva edición crítica conjunta de ambas obras. ABSTRACT: This article explores the historical, editorial and literary circumstances that propitiated the elaboration of a ‘pastoral’ version of El Abencerraje for its interpolation at the end of Book IV of La Diana by Jorge de Montemayor. After analysing the incorporation of the Moorish tale into the editorial sequence of the pastoral text, its literary genesis, the mechanisms of composition and its function in the structure of La Diana, the work offers a reasoned hypothesis about what happened that would justify the preparation of a new critical edition of both works.
Marrying Apollo and Diana Lee Fratantuono
Classica Cracoviensia,
12/2023, Letnik:
26
Journal Article
Recenzirano
Odprti dostop
The anonymous Historia Apollonii Regis Tyri has attracted significant critical commentary in recent years, not the least on questions of authorship and date, and on its relationship to other extant ...Greek and Latin romances and novels. Close study of certain aspects of its plot reveals a carefully wrought, intertextual engagement with Books I and IV of Virgil’s Aeneid and the poet’s comparison of Dido and Aeneas to Diana and Apollo.
En respuesta a los atinados comentarios de mis colegas, defiendo que el externismo no es un inferencialismo, que el color es una dimensión (y, por lo tanto, que los conceptos de color son un tipo de ...conceptos de medida) y que determinamos la forma lógica de las proposiciones expresadas en términos pictóricos de la misma manera que lo hacemos con las proposiciones expresadas en el lenguaje natural.
Background: Diabetic nephropathy (DN) which refers to the cases with biopsy proven kidney lesions, is one of the main complications of diabetes all around the world; however, the underlying ...biological changes causing DN remain to be understood. Studying the alterations in gene expression profiles could give a holistic view of the molecular pathogenicity of DN and aid to discover key molecules as potential therapeutic targets. Here, we performed a meta-analysis study that included microarray gene expression profiles coming from glomerular samples of DN patients in order to acquire a list of consensus Differentially Expressed Genes (meta-DEGs) correlated with DN. Methods: After quality control and normalization steps, five gene expression datasets (GES1009, GSE30528, GSE47183, GSE104948, and GSE93804) were entered into the meta-analysis. The meta-analysis was performed by random effect size method and the meta-DEGs were put through network analysis and different pathway enrichment analyses steps. MiRTarBase and TRRUST databases were utilized to predict the meta-DEGs related miRNAs and transcription factors. A co-regulatory network including DEGs, transcription factors and miRNAs was constructed by Cytoscape, and top molecules were identified based on centrality scores in the network. Results: The identified meta-DEGs were 1364 DEGs including 665 downregulated and 669 upregulated DEGs. The results of pathway enrichment analysis showed, “immune system”, “extracellular matrix organization”, “hemostasis”, “signal transduction”, and “platelet activation” to be the top enriched terms with involvement of the meta-DEGs. After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN. Among the regulatory molecules, miR-335-5p and SP1 were the most interactive miRNA and transcription factor molecules with the highest degree scores in the constructed network. Conclusion: By performing a meta-analysis of available DN-related transcriptomics datasets, we reached a consensus list of DEGs for this complicated disorder. Further enrichment and network analyses steps revealed the involved pathways in the DN pathogenesis and marked the most potential therapeutic targets in this disease. Resumen: Antecedentes: La nefropatía diabética (ND), que se refiere a los casos con lesiones renales comprobadas por biopsia, es una de las principales complicaciones de la diabetes en todo el mundo. Sin embargo, los cambios biológicos subyacentes que causan la ND aún no se han entendido. Aquí realizamos un estudio de metaanálisis que incluyó perfiles de expresión génica de micromatrices provenientes de muestras glomerulares de pacientes con ND para adquirir una lista de genes expresados diferencialmente (meta-DEG) de consenso correlacionados con ND. Métodos: Después de los pasos de control de calidad y normalización, se ingresaron en el metaanálisis cinco conjuntos de datos de expresión génica (GES1009, GSE30528, GSE47183, GSE104948 y GSE93804). El metaanálisis se realizó mediante el método de tamaño de efecto aleatorio y los meta-DEG se sometieron a análisis de red y a diferentes pasos de análisis de enriquecimiento de ruta. Se utilizaron las bases de datos MiRTarBase y TRRUST para predecir los factores de transcripción y los miARN relacionados con los meta-DEG. Cytoscape construyó una red de corregulación que incluye DEG, factores de transcripción y miARN, y las moléculas principales se identificaron en función de las puntuaciones de centralidad en la red. Resultados: Los meta-DEG identificados fueron 1.364 DEG, incluidos 665 DEG regulados negativamente y 669 regulados positivamente. Los resultados del análisis de enriquecimiento de vías mostraron que «sistema inmunitario», «organización de la matriz extracelular», «hemostasia», «transducción de señales» y «activación de plaquetas» son los términos más enriquecidos con la participación de los meta-DEG. Después de la construcción de la red reguladora multicapa, varios DEG principales (TP53, MYC, BTG2, VEGFA, PTEN, etc.), así como miARN principales (miR-335, miR-16, miR-17, miR-20a y miR -93) y factores de transcripción (SP1, STAT3, NF-KB1, RELA, E2F1) se introdujeron como posibles dianas terapéuticas en la ND. Entre las moléculas reguladoras, miR-335-5p y SP1 fueron las moléculas de factor de transcripción y miARN más interactivas con las puntuaciones de grado más altas en la red construida. Conclusión: Al realizar un metaanálisis de los conjuntos de datos transcriptómicos relacionados con ND disponibles, llegamos a una lista de consenso de DEG para este trastorno complicado. Los pasos posteriores de enriquecimiento y análisis de redes revelaron las vías involucradas en la patogénesis de la ND y marcaron los objetivos terapéuticos más potenciales en esta enfermedad.
Diana Scully intellectually, politically, and personally touched the lives of many people. Though she has left this world, her ground-breaking sexual assault research continues to influence many ...feminist scholars who examine various types of violence against women. This article points to some of her most noteworthy contributions to the field.
This essay is a tribute to the former founding Department Chair of Women's Studies at Virginia Commonwealth University, Dr. Diana Scully, by Liz Canfield, a current Associate Chair of the same ...department.
Recently, a new method was introduced to detect neuronal activity using Magnetic Resonance Imaging (MRI). The method, referred to as DIANA, showed MRI signals with millisecond temporal resolution ...that correlated with local field potentials measured invasively in mice. Troublingly, attempts by other groups to detect the DIANA signals in humans at 7 Tesla and mice at 15.2 Tesla have failed. So far, attempts to reproduce DIANA in small rodents have focused on paradigms using whisker pad stimulation, which were expected to produce a 0.1–0.15% signal change. However, the Supplementary Material accompanying the original DIANA paper showed that visual stimulation produced a three times larger signal, which should be much easier to detect. Therefore, we attempted to find the DIANA signal in rats using a visual stimulation paradigm. Experiments were performed at 17.2 Tesla but also at 7.0 Tesla to see if the DIANA signal appears at a lower field strength where T2 is longer and BOLD contributions are reduced. In addition, simulations were performed to investigate the theoretical detectability of synthetic DIANA signals in noisy data. Although our data indicated that a 0.1% signal change would have been detectable, we did not observe a DIANA signal. We did observe neuronally driven hemodynamic signal variations that were much larger than the anticipated DIANA signal. The amplitude of these signal changes was relatively similar at 7.0 and 17.2 Tesla (0.7% vs 1.1%). Numerical simulations indicated, however, that the measured hemodynamic signal changes would not interfere with the detection of DIANA signals. Therefore, it is reasonable to expect that measurements at higher field strength with improved SNR would have a better chance to detect the DIANA signal. Yet, we, among others, were unable to find it.
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