Nahrávání probehlo na nekolika místech Moravy a byly pri nem zaznamenány predevsím slovenské písne. Prepisy textu ve druhém svazku jsou pripojeny proto, ze texty mohou být pro velkou cást uzivatelu ...nesrozumitelné. K údaji o vyuzívání celostopého záznamu pouze v profesionálních studiích muzeme dodat, ze i na brnenském akademickém pracovisti se v terénu porizovaly od roku 1964 výhradne celostopé záznamy lidových písní hudby na profesionálním magnetofonu firmy Kudelski Nagra III B. Ve druhém svazku nejsou prepsány nekteré komentáre k písním, i kdyz se na ne v textu upozornuje.
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•Activated carbons (ACs) were synthesized from DVDs and CDs wastes as precursor.•CNTs coated on the surface of the as-prepared ACs from CDs and DVDs.•The CNTs/CDsAC and CNTs/DVDsAC ...adsorbents were tested for the adsorption of AO7.•Influential parameters, kinetics, equilibrium and reusability were studied.
The purpose of the present work was to prepare activated carbon (AC) from low-cost wastes, such as digital versatile discs (DVDs) and compact discs (CDs), coated with carbon nanotubes (CNTs) for adsorption of Acid Orange 7 (AO7) from dye-containing solutions. The surface morphology of the activated carbons from DVDs (DVDsAC), CDs (CDsAC), CNTs, CNTs/DVDsAC and CNTs/CDsAC was determined by XRD and SEM techniques. SEM micrographs of adsorbents clearly show a heterogeneous porous surface with irregular pores in the structure of the activated carbons. Results showed that CNTs/DVDsAC (30.3mg/g) and CNTs/CDsAC (32.8mg/g), in comparison with DVDsAC (15.1mg/g) and CDsAC (9.9mg/g), were more efficient adsorbents for the adsorption of AO7. The dye adsorption amount (qe) increases with a reduction in the solution pH, adsorbent dosage and an increase in the initial concentration of AO7 for these two more efficient adsorbents. Pseudo-second order model and Langmuir isotherm fitted with the experimental data. The spontaneous and endothermic processes were analyzed by the thermodynamic studies for the adsorption of AO7. The negative values of ΔG, and the positive values of ΔH and ΔS parameters indicate that the adsorption of AO7 onto CNTs/CDsAC and CNTs/DVDsAC was spontaneous and endothermic, respectively.
•We fabricate a humidity sensor with laser-scribed graphene electrode and graphite oxide sensing layer.•The fabrication process is done by a low power (5 mW) DVD drive.•The LSG-GO humidity sensor ...operates in the relative humidity (RH) range of 19 %–97.4 %.•The LSG based humidity sensor demonstrates high sensitivity (4770.14 pF/% RH).•Excellent sensing stability for more than 30 days has been demonstrated.
Monitoring the environmental humidity are of great significance to human comfort and product quality in many fields. However, high performance humidity sensors are difficult to be widely used because of their cost and complex preparation process. It is also highly desirable to develop a facile fabrication method that is capable of producing humidity sensors of customized size, shape, and geometry. Here, using a low power DVD drive, we successfully fabricate a highly sensitivity and low-cost humidity sensor, consisting of laser-scribed graphene (LSG) electrode and graphite oxide (GO) sensing layer. The LSG-GO humidity sensor operates in the relative humidity (RH) range of 19 %–97.4 %, demonstrating high sensitivity (4770.14 pF/% RH), quick response/recovery, and excellent sensing stability. In addition, the possible humidity sensing mechanism is discussed with the help of impedance spectroscopy. These results indicate that the LSG/GO sensor, enabled by the facile fabrication process with low power DVD drives, demonstrates promising potential with broad application prospects.
Abstract
Introduction:
Recently we attempted an ECG recording in intact freely-behaving mice by using a plate sensor that has multiple (15) gold-plated electrodes, on which mice can walk around ...freely, without the use of tether or telemetry system. Although the electrodes are a kind of dry electrode, we found that the ECG plate sensor detects ECG from mouse’s footpads during sleep or even during wake-sleep transition probably because of the sweating from their footpads.
Methods:
A mouse cage, in which the ECG plate sensor was mounted, was placed in a Faraday cage. Fifteen ECG signals of the ECG plate sensor were fed to a PC via a 15-channel amplifier and a 16-channel A/D converter with using Clampex7 (Axon Instruments) signal acquisition software. Mouse behavior was also recorded by a DVD recorder. Intact, wild-type C57BL/6J mice were simply put on the ECG plate sensor for the recording for about 2 hours.
Results:
Although the ECG plate sensor could not detect ECG most of the period during active state, ECG signal appeared relatively stably during sleep state from 10 out of 12 mice examined; two mice did not fall asleep within 2 hours. The ECG appearance during sleep continued for a maximum of ~15 minutes and disappeared when they awoke. One mouse allowed us to record ECG from the period before sleep onset that appeared to be quiet waking state based on the images stored in the DVD recorder.
Conclusion:
The physiological role of the sweating during sleep in mice is inexplicable because most of mammals including mice have eccrine sweat glands that are considered to be activated by sympathetic nerve activity in response to emotional stressors, to which mice would not exposed during sleep. Nonetheless, the finding of the sweating during sleep in mice that enables noninvasive ECG recording may provide us a new tool to investigate cardiac and autonomic nervous system activities during sleep and wake-sleep transition states.
Support (If Any):
This work was supported by a JSPS KAKENHI Grant, Number 24590268, Tokyo, Japan.
Summary Bortezomib is regularly used as frontline therapy for systemic AL amyloidosis. We assess the efficacy of second‐line daratumumab‐bortezomib‐dexamethasone (DVD) in AL amyloidosis in ...bortezomib‐exposed patients. A total of 116 patients treated with second‐line DVD were identified from a prospective observational study of newly diagnosed AL amyloidosis (ALchemy). DVD was initiated in both the relapsed setting or where there was an inadequate response defined as very good partial response (VGPR) or VGPR with organ progression/lack of organ improvement. A complete response (CR)/VGPR to second‐line DVD was achieved in 81 (69.8%) patients. A CR/VGPR was achieved in 67 (79.7%) in those who achieved a VGPR/CR to first line versus 14/32 (43.8%) in those who did not. Where DVD was initiated due to an inadequate response to first line (vs. at relapse), the median event‐free survival (EFS) was 18 vs. 34 months ( p = 0.002). If a CR/VGPR was achieved to DVD, the 2‐year EFS was still lower in those with prior inadequate response 54% vs. 66% ( p = 0.062). DVD is an efficacious second‐line treatment in systemic AL amyloidosis in a bortezomib‐exposed population. However, the response to DVD is poorer in those with an inadequate response to first‐line bortezomib.
Autonomous driving, unmanned aerial vehicles (UAVs), and various other vehicular navigation schemes heavily depend on the accurate position, velocity, and timing (PVT) information offered by global ...navigation satellite systems (GNSSs). Meanwhile, GNSS security is challenged by spoofing attacks that aim to deceive users by inducing false PVT solutions. Therefore, detecting these attacks on time is vital for vehicular navigation security. Spoofing attacks involve transmitting counterfeit signals from spoofers instead of authentic satellites, making it difficult to coordinate spatial information accurately. To this end, the Doppler shift, revealing spatial features between transmitters and receivers, is regarded as an effective metric for spoofing detection. Especially for vehicles, due to their motion relative to the spoofer, Doppler bias is appended to the raw measurement, providing an observable spoofing signature. Conventional approaches tend to directly monitor the Doppler bias but require complex requirements like static initialization, random motion, and multiple receivers. Moreover, the commonly utilized single-antenna assumption renders them ineffective against multi-antenna spoofing attacks. This paper proposes a new approach that indirectly exploits the Doppler bias by examining its adverse impact on velocity consistency. The introduced direct velocity determination (DVD) method calculates velocity directly from the Doppler measurements, which is then utilized for consistency-checking alongside the velocity obtained from the conventional pseudorange-aided approach. We thoroughly investigate the impact of Doppler bias on velocities and analyze their consistency across different scenarios. Field tests validate the effectiveness of the proposed method, surpassing previous Doppler-based methods and the widely used receiver autonomous integrity monitoring (RAIM) method.
1,25(OH)2D3 (vitamin D) appears essential for the normal development of dopaminergic neurons. Vitamin D affects dopamine synthesis and metabolism as well as expression of glial cell line–derived ...neurotrophic factor (GDNF), which is crucial for the survival of dopaminergic neurons. We investigated the role of vitamin D on GDNF and its receptors protooncogene tyrosine–protein kinase receptor Ret (C‐Ret) and GDNF family receptor alpha 1 (GFRα1) signaling. To this end, we used a developmental vitamin D–deficient rat model and SH‐SY5Y cells transfected with vitamin D receptor (VDR). The absence of vitamin D ligand in gestation reduces C‐Ret expression, but not GDNF and GFRα1, in embryo forebrains. Overexpression of VDR in SH‐SY5Y in the absence of ligand (mimicking in vivo developmental vitamin D deficiency) also suppressed C‐Ret mRNA levels. In the presence of vitamin D, C‐Ret mRNA and protein expression were increased. The chromatin immunoprecipitation results suggested that C‐Ret is directly regulated by vitamin D via VDR. GDNF was also increased by vitamin D in these cells. Our small interfering RNA studies showed that knocking down VDR leads to an increase in C‐Ret in the absence of ligand. Finally, we confirmed the inverse relationship between GFRα1 and C‐Ret, as knocking down C‐Ret led to increases in GFRα1 expression. These data extend our knowledge of the diverse and important roles played by vitamin D in dopamine physiology.—Pertile, R.A.N., Cui, X., Hammond, L., Eyles, D.W. Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons. FASEB J. 32, 819–828 (2018). www.fasebj.org
The anti-CD38 antibody daratumumab has been available in Hungary since 2017 for multiple myeloma (MM) patients, used mainly in combinations with lenalidomide or bortezomib. As the majority of ...patients are refractory to lenalidomide by the time of third-line treatment, where daratumumab is financed, we generally prefer the bortezomib (DVd) combination.
To evaluate our real-world results compared to CASTOR study outcomes.
Retrospective overview of the mandatory reporting system for all daratumumab treatments and our own clinical data from January 2017 to May 2023.
University clinic with a myeloma center.
Every patient with MM that received at least 1 cycle of daratumumab in combination with bortezomib and dexamethasone until May 2023 was included (57 patients). We evaluated the number of previous lines of therapy, lenalidomide refractivity, and cytogenetic risk factors.
Hematologic response rates and progression-free survival (PFS).
Unlike in the CASTOR study, where patients received daratumumab in the median second line and only 18% were refractory to lenalidomide, our patients were treated in the median third line and 75% were refractory to lenalidomide. Unsurprisingly, median PFS at our clinic, 11.4 months, proved worse than the median 16.8 months PFS in CASTOR. Remarkably however, the comparison of only third- or fourth-line treated patients showed a significantly better median PFS at our clinic (14.9 vs 9.8 months). This is most likely due to different bortezomib treatment regimens: while in the CASTOR study bortezomib was administered twice a week in the beginning and not at all after 6 months, our protocol included weekly doses at the start and continued bortezomib treatment concurrently with the daratumumab infusions until progression.
A less dose-intensive bortezomib protocol may provoke fewer therapylimiting neuropathies and allow for the continuation of combination therapy, utilizing the synergism of proteasome inhibition and anti-CD38 antibodies and thereby prolonging PFS.
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