Red Cell Distribution Width (RDW-CV %), Neutrophil lymphocyte ratio (NLR), and Platelet lymphocyte ratio (PLR) were proposed as prognostic biomarkers for COVID-19 patients, but limited research ...exists with varying results1 . Furtherinvestigation is needed,particularly in India.
Background and Aim The high use of pesticides has increased the concern about its possible harm to individual and environment health. Chronic exposure to pesticides has serious effects on different ...body organs even before the onset of clinical symptoms. In this study, we aim to evaluate clinical and biochemical characteristics of male workers in a pesticide production factory in Guilan province, Iran. Methods & Materials This cross-sectional study was conducted on 99 male workers exposed to pesticide and 107 people without exposure who were employed in a pesticide production factory in Guilan and selected using a convenience sampling method in 2020. Their demographical data as well as clinical characteristics such as respiratory symptoms (cough, shortness of breath, etc.), neurological symptoms (fatigue, tremors, cramps, muscle weakness, etc.), psychological symptoms (sleep disorders, anxiety, etc.) and skin symptoms (redness, itching, etc.) were collected from the occupational health records of the workers. Finally, the biochemical parameters were compared between the two groups. Statistical analysis was performed in SPSS software, version 16. Ethical Considerations This study was approved by the Research Ethics committee of Guilan University of Medical Science, Rasht, Iran (Code: IR.GUMS.REC.1399.632). Informed consent was obtained from all participants in this study. Results The frequency of symptoms such as headache, itchy skin, cough, and sleep disorders was higher in the exposed group (P<0.05). Based on the biochemical findings, blood urea level, creatinine level, alkaline phosphatase, and fasting blood sugar level were significantly higher in the exposed group (P<0.05). Thrombocytosis was observed in 9.09% of exposed workers, which was higher in those with more than 11 years of work experience. Conclusion Chronic exposure to pesticide can cause thrombosis, changes in biochemical parameters, and clinical symptoms. It is recommended that biological monitoring should be conducted in exposed workers at a shorter interval.
Perioperative transfusion is reported to be an independent risk factor not only for postoperative complications but also for early recurrence of periampullary carcinoma after pancreaticoduodenectomy ...(PD). The purpose of this study was to evaluate the safety and efficacy of ferric carboxymaltose (FCM) in reducing the need for perioperative transfusion in iron deficiency anemia patients scheduled for PD.
Twenty-two male patients (hemoglobin Hb 7 to <13 g/dL) and 18 female patients (Hb 7 to <12 g/dL) were enrolled in the study group and administered FCM 1-3 weeks before PD. The perioperative transfusion rate was the primary endpoint; morbidity, length of postoperative hospital stay, change in hematological parameters after FCM injection, and adverse effects of FCM were also investigated.
The perioperative transfusion rate of the study group was 22.5% (9 of 40). Hb level was significantly higher on the day of the operation compared to baseline (P < 0.001). Levels of Hb, transferrin saturation, and ferritin were higher at the follow-up compared to baseline (P = 0.008, P = 0.033, and P < 0.001, respectively).
FCM administration was associated with a reduced need for perioperative transfusion and can safely stabilize hematological parameters.
Background
Peripheral blood analysis is a non‐invasive and low‐cost technique of prognostic value for several diseases, including oral cancer. Considering the role of inducible nitric oxide synthase ...in tumor‐associated inflammation, this study purposed to evaluate the influence of this enzyme on peripheral blood parameters and systemic inflammatory biomarkers during murine oral carcinogenesis.
Methods
A 50 μg/mL solution of 4‐nitroquinoleine‐N‐oxide was provided to 15 C57BL/6J (Nos2+/+) and 16 B6.129P2‐Nos2tm1Lau/J (Nos2−/−) for 16 weeks. Animals were followed for 8 weeks after treatment. Blood samples and tongues were collected for hematological and histopathological analyses. Red blood cells, white blood cells, and platelet cell parameters were analyzed. The neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and the systemic immune‐inflammation index were also calculated. The depth of invasion of all carcinomas was measured.
Results
Differences were found in several blood parameters. The depth of invasion in Nos2−/− was lower than in Nos2+/+ (p = 0.009), and strong correlations were found between depth of invasion and neutrophil count (ρ = −0.68, p = 0.017), lymphocyte count (ρ = 0.72, p = 0.011), neutrophil‐to‐lymphocyte ratio (ρ = −0.65, p = 0.025), platelet‐to‐lymphocyte ratio (ρ = −0.73, p = 0.013), and systemic immune‐inflammation index (ρ = −0.67, p = 0.037) in Nos2−/− mice.
Conclusion
Inducible nitric oxide synthase seems to have an important role in OSCC invasion and progression, which might be associated to alterations in immune‐inflammatory cell dynamics evidenced by peripheral blood and systemic inflammatory biomarkers.
Long COVID affects many individuals following acute coronavirus disease 2019 (COVID-19), and hematological changes can persist after the acute COVID-19 phase. This study aimed to evaluate these ...hematological laboratory markers, linking them to clinical findings and long-term outcomes in patients with long COVID. This cross-sectional study selected participants from a 'long COVID' clinical care program in the Amazon region. Clinical data and baseline demographics were obtained, and blood samples were collected to quantify erythrogram-, leukogram-, and plateletgram-related markers. Long COVID was reported for up to 985 days. Patients hospitalized in the acute phase had higher mean red/white blood cell, platelet, and plateletcrit levels and red blood cell distribution width. Furthermore, hematimetric parameters were higher in shorter periods of long COVID than in longer periods. Patients with more than six concomitant long COVID symptoms had a higher white blood cell count, a shorter prothrombin time (PT), and increased PT activity. Our results indicate there may be a compensatory mechanism for erythrogram-related markers within 985 days of long COVID. Increased levels of leukogram-related markers and coagulation activity were observed in the worst long COVID groups, indicating an exacerbated response after the acute disturbance, which is uncertain and requires further investigation.
The presence of comorbidities, especially those with a chronic inflammatory nature such as periodontitis, can facilitate COVID-19 progression toward more severe forms. Both of these diseases can ...affect systemic health and alter hematological test results. In this study, we decided to investigate COVID-19 and periodontitis' possible interaction with these alterations.
Hospitalized patients with a definitive diagnosis of COVID-19 were included. Controls had mild to moderate COVID-19, while cases had severe to critical COVID-19. Periodontal examination was done for each patient. Relevant medical and hematological data were extracted from patient's hospital files.
A total of 122 patients entered the final analysis. The minimum white blood cell counts were associated with the severity of periodontitis. The interaction between periodontitis and COVID-19 was associated with increased minimum white blood cell counts and decreased platelet counts. COVID-19 severity was associated with increased venous oxygen saturation, prothrombin time, the maximum partial thromboplastin time, the maximum and average urea, the maximum creatinine, the maximum potassium, and lactate dehydrogenase, and decreased sodium levels.
Results of this study showed that several blood parameters were associated with periodontitis, COVID-19, or the interaction between them.
In some developing countries in Africa, Asia, and Latin America, rapid population growth is a complicated problem, and thus, it is necessary to raise the efficiency of foodstuff production to ...preserve human life. Therefore, this study was designed to investigate the effect of fish oil supplementation on male rabbits' productivity, as well as their biochemical and physiological characteristics. This experiment was conducted in the Animal House of the College of Veterinary Medicine, University of Baghdad (Baghdad, Iraq) for eight weeks. Twenty-four local male rabbits were randomly divided into three groups (each containing eight rabbits) as follows: the control group that was fed with a basal diet only, the first treated group in which each animal received fish oil orally at a dose of 0.75 ml every day, and another treated group in which each animal received fish oil orally at a dose of 1.5 ml every day. Both treated groups received the treatment for 60 days. Blood samples were collected from cardiac veins by cardiac puncture at the beginning of the experiment (Zero time). On day 60 of the experiment, samples were collected again to analyze potential changes in blood characteristics, including white blood cells count, hemoglobin, and red blood cells count. These blood samples recorded a significant decrease in cholesterol in the two treatment groups, compared to the control. In conclusion, the current findings recommend daily oral administration of fish oil at a dose of 0.75 mg/ml or 1.5 mg/ml to rabbits for 60 days before conception to improve performance trials, as well as biochemical and hematological results. These alterations, however, have a small impact on these features, compared to higher doses administered to rabbits.
Radiologic technologists in Saudi Arabia Makkawi, Mohammed; Alasmari, Sultan; Shubayr, Nasser A ...
Saudi medical journal,
08/2021, Letnik:
42, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Objectives: To determine the influence of prolonged exposure to radiation based on dosimeter readings on hematological parameters among radiologic technologists (RTs) in Saudi Arabia. Methods: The ...study was specifically conducted on selected RTs with experience of more than 10 years and the highest thermoluminescent dosimeter (TLD) readings among all RTs in the Radiological Department, Sabya General Hospital, Ministry of Health, Saudi Arabia from August to October 2020. The RTs group was compared with a control group of non-irradiated participants. Blood samples were collected for hematological and coagulation profile evaluation. Results: The acquired radiation dose analysis revealed that the average accumulated dose in 10 years is 7.6 mSv. The medians of prothrombin time (PT) and activated partial thromboplastin time (APTT) of the RTs group were significantly lower when compared to the control group. In addition, RTs group exhibited a significant reduction in neutrophil count and an elevation in lymphocyte count. Conclusion: Chronic exposure to radiation revealed a significant change in blood tests and may reflect an effect on RTs tissues, leading to serious health problems. However, further investigation in a large cohort to study the association between alteration in hematological parameters and chronic radiation exposure is required. Keywords: ionizing radiation, radiation dosage, radiation exposure, hematological tests, coagulation tests
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