The first micro-historical 'ethnology of reading' in the Early Slavic field,Byzantine Hermeneutics and Pedagogy in the Russian Northwill prove fascinating to western medievalists, Byzantinists, ...Slavists, and book historians.
Drawing upon hundreds of newly uncovered archival records, Gretchen Peters reconstructs the music of everyday life in over twenty cities in late medieval France. Through the comparative study of ...these cities' political and musical histories, the book establishes that the degree to which a city achieved civic authority and independence determined the nature and use of music within the urban setting. The world of urban minstrels beyond civic patronage is explored through the use of diverse records; their livelihood depended upon seeking out and securing a variety of engagements from confraternities to bathhouses. Minstrels engaged in complex professional relationships on a broad level, as with guilds and minstrel schools, and on an individual level, as with partnerships and apprenticeships. The study investigates how minstrels fared economically and socially, recognizing the diversity within this body of musicians in the Middle Ages from itinerant outcasts to wealthy and respected town musicians.
Major declines in insect biomass and diversity, reviewed here, have become obvious and well documented since the end of World War II. Here, we conclude that the spread and intensification of ...agriculture during the past half century is directly related to these losses. In addition, many areas, including tropical mountains, are suffering serious losses because of climate change as well. Crops currently occupy about 11% of the world's land surface, with active grazing taking place over an additional 30%. The industrialization of agriculture during the second half of the 20th century involved farming on greatly expanded scales, monoculturing, the application of increasing amounts of pesticides and fertilizers, and the elimination of interspersed hedgerows and other wildlife habitat fragments, all practices that are destructive to insect and other biodiversity in and near the fields. Some of the insects that we are destroying, including pollinators and predators of crop pests, are directly beneficial to the crops. In the tropics generally, natural vegetation is being destroyed rapidly and often replaced with export crops such as oil palm and soybeans. To mitigate the effects of the Sixth Mass Extinction event that we have caused and are experiencing now, the following will be necessary: a stable (and almost certainly lower) human population, sustainable levels of consumption, and social justice that empowers the less wealthy people and nations of the world, where the vast majority of us live, will be necessary.
Cannabis sativa L. (C. sativa) is an annual dioecious plant, which shares its origins with the inception of the first agricultural human societies in Asia. Over the course of time different parts of ...the plant have been utilized for therapeutic and recreational purposes, for instance, extraction of healing oils from seed, or the use of inflorescences for their psychoactive effects. The key psychoactive constituent in C. sativa is called Δ-9-tetrahydrocannabinol (D9-THC). The endocannabinoid system seems to be phylogenetically ancient, as it was present in the most primitive vertebrates with a neuronal network. N-arachidonoylethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG) are the main endocannabinoids ligands present in the animal kingdom, and the main endocannabinoid receptors are cannabinoid type-1 (CB1) receptor and cannabinoid type-2 (CB2) receptor.
The review aims to provide a critical and comprehensive evaluation, from the ancient times to our days, of the ethnological, botanical, chemical and pharmacological aspects of C. sativa, with a vision for promoting further pharmaceutical research to explore its complete potential as a therapeutic agent.
This study was performed by reviewing in extensive details the studies on historical significance and ethnopharmacological applications of C. sativa by using international scientific databases, books, Master’s and Ph.D. dissertations and government reports. In addition, we also try to gather relevant information from large regional as well as global unpublished resources. In addition, the plant taxonomy was validated using certified databases such as Medicinal Plant Names Services (MPNS) and The Plant List.
A detailed comparative analysis of the available resources for C. sativa confirmed its origin and traditional spiritual, household and therapeutic uses and most importantly its popularity as a recreational drug. The result of several studies suggested a deeper involvement of phytocannabinoids (the key compounds in C. sativa) in several others central and peripheral pathophysiological mechanisms such as food intake, inflammation, pain, colitis, sleep disorders, neurological and psychiatric illness. However, despite their numerous medicinal benefits, they are still considered as a menace to the society and banned throughout the world, except for few countries. We believe that this review will help lay the foundation for promoting exhaustive pharmacological and pharmaceutical studies in order to better understand the clinical relevance and applications of non-psychoactive cannabinoids in the prevention and treatment of life-threatening diseases and help to improve the legal status of C. sativa.
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This book adds an entirely new dimension to the consideration of
Humanism and Italian culture. It will make a welcome addition to the field of
cultural studies by broadening the subject to consider ...an important source of
information that has been previously overlooked. -- Timothy
McGee The Eloquent Body offers a history and analysis of court
dancing during the Renaissance, within the context of Italian Humanism. Each chapter
addresses different philosophical, social, or intellectual aspects of dance during
the 15th century. Some topics include issues of economic class, education, and
power; relating dance treatises to the ideals of Humanism and the meaning of the
arts; ideas of the body as they relate to elegance, nobility, and ethics; the
intellectual history of dance based on contemporaneous readings of Pythagoras and
Plato; and a comparison of geometric dance structures to geometric order in Humanist
architecture.
Soil carbon debt of 12,000 years of human land use Sanderman, Jonathan; Hengl, Tomislav; Fiske, Gregory J.
Proceedings of the National Academy of Sciences - PNAS,
09/2017, Letnik:
114, Številka:
36
Journal Article
Recenzirano
Odprti dostop
Human appropriation of land for agriculture has greatly altered the terrestrial carbon balance, creating a large but uncertain carbon debt in soils. Estimating the size and spatial distribution of ...soil organic carbon (SOC) loss due to land use and land cover change has been difficult but is a critical step in understanding whether SOC sequestration can be an effective climate mitigation strategy. In this study, a machine learning-based model was fitted using a global compilation of SOC data and the History Database of the Global Environment (HYDE) land use data in combination with climatic, landform and lithology covariates. Model results compared favorably with a global compilation of paired plot studies. Projection of this model onto a world without agriculture indicated a global carbon debt due to agriculture of 133 Pg C for the top 2 m of soil, with the rate of loss increasing dramatically in the past 200 years. The HYDE classes “grazing” and “cropland” contributed nearly equally to the loss of SOC. There were higher percent SOC losses on cropland but since more than twice as much land is grazed, slightly higher total losses were found from grazing land. Important spatial patterns of SOC loss were found: Hotspots of SOC loss coincided with some major cropping regions as well as semiarid grazing regions, while other major agricultural zones showed small losses and even net gains in SOC. This analysis has demonstrated that there are identifiable regions which can be targeted for SOC restoration efforts.
Defining the anthropocene Lewis, Simon L; Maslin, Mark A
Nature (London),
03/2015, Letnik:
519, Številka:
7542
Journal Article
Recenzirano
Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the ...Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record against the formal requirements for the recognition of a new epoch. The evidence suggests that of the various proposed dates two do appear to conform to the criteria to mark the beginning of the Anthropocene: 1610 and 1964. The formal establishment of an Anthropocene Epoch would mark a fundamental change in the relationship between humans and the Earth system.
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Topical products, widely used to manage skin conditions, have evolved from simple potions to sophisticated delivery systems. Their development has been facilitated by advances in ...percutaneous absorption and product design based on an increasingly mechanistic understanding of drug-product-skin interactions, associated experiments, and a quality-by-design framework. Topical drug delivery involves drug transport from a product on the skin to a local target site and then clearance by diffusion, metabolism, and the dermal circulation to the rest of the body and deeper tissues. Insights have been provided by Quantitative Structure Permeability Relationships (QSPR), molecular dynamics simulations, and dermal Physiologically Based PharmacoKinetics (PBPK). Currently, generic product equivalents of reference-listed products dominate the topical delivery market. There is an increasing regulatory interest in understanding topical product delivery behavior under ‘in use’ conditions and predicting in vivo response for population variations in skin barrier function and response using in silico and in vitro findings.
Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise ...developed through trial and error, clinical observation and evidence‐based studies that date back to the first existing human records. This review begins with the earliest topical therapies and traces topical delivery to the present‐day transdermal patches, describing along the way the initial trials, devices and drug delivery systems that underpin current transdermal patches and their actives. This is followed by consideration of the evolution in the various patch designs and their limitations as well as requirements for actives to be used for transdermal delivery. The properties of and issues associated with the use of currently marketed products, such as variability, safety and regulatory aspects, are then described. The review concludes by examining future prospects for transdermal patches and drug delivery systems, such as the combination of active delivery systems with patches, minimally invasive microneedle patches and cutaneous solutions, including metered‐dose systems.
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