Existing research suggests that regions can develop their long-term competitive advantage through well-functioning interregional innovation cooperation. In this article, we use the example of ...innovation in small and medium-sized agri-food enterprises (SMEs) to scrutinise and compare regional innovation approaches on each side of the Dutch-German border and explore how they can converge into a cross-border innovation space. Particular attention is paid to the role of academic institutions and innovation brokers in creating a common innovation space. We explore how differences between two cross-border regions can be harnessed to enhance the impact of innovation, and how this may lead to what we describe as hybridisation effects. In the empirical analysis, we apply the concept of hybridisation to a cross-border innovation space, something that, as far as we are aware, has not been done before. We empirically ground the concepts of a cross-border innovation space and hybridisation and illustrate how relative regional strengths can lead to hybridisation effects. We conclude that differences in economic structures, institutional set-ups, visions and identities inherent in cross-border spaces are not only hindrances, but also opportunities, and we highlight the importance of these complementary strengths and the potential for their strategic use by regional innovation actors. Our findings are highly relevant for the further development of the Interreg Europe programme and the implementation of the EU’s Territorial Agenda 2030.
This paper extends existing research on inclusive place marketing by advancing methodological reflections on how to rework research instruments toward greater inclusivity. Our methodological ...reflections intend to encourage the dialogue between place marketing theory and practice, as well as reflections on the role that academic researchers take on while co-creating territorial development and promotion projects with a variety of non-academic stakeholders. This is done in the form of a self-reflective account of the multi-disciplinary tourism research team engaged in “RECOLOR” (Reviving and EnhanCing artwOrks and Landscapes Of the adRiatic). This is an INTERREG project funded by the European Commission that aims to enhance the tourist potential of secondary urban and natural resources in Croatia and Italy, with a view to generating sustainable development. Academics and consultants can replicate the research methods suggested in this paper when conducting participatory audits in other destinations.
Since 1989 the European Commission's policy on border regions has slowly shifted focus. Current Interreg policy is increasingly focused upon innovation and cooperation between SMEs. In this paper we ...question whether this emphasis on firms and innovation neglects the build-up of other kinds of activities and institutions antecedent to effective firm innovation cooperation. We argue that antecedent developments should occur prior to stimulating innovation cooperation between firms, highlighting that building effective environments for regional innovation in cross-border regions encompasses four qualitatively different micro scale phases of development, each requiring qualitatively different policy measures. This four-phase model is applied to a case study of a Dutch-Flemish Interreg programme, using documentary material, a policy-maker survey and a documentary analysis of funded projects to explore incoherences between strategy and reality. We highlight a gap between the strategy's strong ex ante focus upon innovation, policy-maker perceptions of necessary improvements, and the projects selected for funding.
Infliximab is a monoclonal antibody that plays an important role in the management and treatment of chronic inflammatory bowel diseases (IBD). Due to its macromolecular structure, its delivery ...through the oral route is challenging, limiting its administration to only via the parenteral route. The rectal route offers an alternative way for administering infliximab, allowing it to be localised at the disease site and circumventing its passage across the alimentary canal and thus, maintaining its integrity and bioactivity. Three-dimensional (3D) printing is an advanced production technology that permits the creation of dose-flexible drug products from digital designs. The current study assessed the feasibility of utilising semi-solid extrusion 3D printing for the fabrication of infliximab-loaded suppositories for the local treatment of IBD. Various printing inks composed of Gelucire® (48/16 or 44/14) mixed with coconut oil and/or purified water were investigated. It was shown that following reconstitution in water, the infliximab solution can be directly incorporated into the printing ink of Gelucire® 48/16 and can withstand the extrusion process, resulting in well-defined suppositories. Since water content and temperature are critical for safeguarding infliximab's potency, the effect of changing the composition of the printing inks and printing parameters on infliximab's biologic efficiency was evaluated by measuring its binding capacity (i.e., the amount of infliximab that actively binds to its antigen to exert an effect). Despite drug loading assays showing that infliximab remains intact following printing, it was found that the incorporation of water in isolation results in only ∼65% binding capacity. However, when oil is added to the mixture, infliximab's binding capacity increases up to ∼85%. These promising results demonstrate that 3D printing has the potential to be exploited as a novel platform for fabricating dosage forms containing biopharmaceuticals, avoiding patients' compliance issues observed with injectables and addressing their unmet needs.
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Acute severe ulcerative colitis (ASUC) is a growing health burden that often requires treatment with multiple therapeutic agents. As inflammation is localised in the rectum and colon, local drug ...delivery using suppositories could improve therapeutic outcomes. Three-dimensional (3D) printing is a novel manufacturing tool that permits the combination of multiple drugs in personalised dosage forms, created based on each patient's disease condition. This study, for the first time, demonstrates the feasibility of producing 3D printed suppositories with two anti-inflammatory agents, budesonide and tofacitinib citrate, for the treatment of ASUC. As both drugs are poorly water-soluble, the suppositories' ability to self-emulsify was exploited to improve their performance. The suppositories were fabricated via semi-solid extrusion (SSE) 3D printing and contained tofacitinib citrate and budesonide in varying doses (10 or 5 mg; 4 or 2 mg, respectively). The suppositories displayed similar dissolution and disintegration behaviours irrespective of their drug content, demonstrating the flexibility of the technology. Overall, this study demonstrates the feasibility of using SSE 3D printing to create multi-drug suppositories for the treatment of ASUC, with the possibility of titrating the drug doses based on the disease progression.
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Inkjet printing has been extensively explored in recent years to produce personalised medicines due to its low cost and versatility. Pharmaceutical applications have ranged from orodispersible films ...to complex polydrug implants. However, the multi-factorial nature of the inkjet printing process makes formulation (e.g., composition, surface tension, and viscosity) and printing parameter optimization (e.g., nozzle diameter, peak voltage, and drop spacing) an empirical and time-consuming endeavour. Instead, given the wealth of publicly available data on pharmaceutical inkjet printing, there is potential for a predictive model for inkjet printing outcomes to be developed. In this study, machine learning (ML) models (random forest, multilayer perceptron, and support vector machine) to predict printability and drug dose were developed using a dataset of 687 formulations, consolidated from in-house and literature-mined data on inkjet-printed formulations. The optimized ML models predicted the printability of formulations with an accuracy of 97.22%, and predicted the quality of the prints with an accuracy of 97.14%. This study demonstrates that ML models can feasibly provide predictive insights to inkjet printing outcomes prior to formulation preparation, affording resource- and time-savings.
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Within an E.U.-funded project, BESS (Pocket Beach Management and Remote Surveillance System), the notion of a geographic information system is an indispensable tool for managing the dynamics of ...georeferenced data and information for any form of territorial planning. This notion was further explored with the creation of a WebGIS portal that will allow local and regional stakeholders/authorities obtain an easy remote access tool to monitor the status of pocket beaches (PB) in the Maltese Archipelago and Sicily. In this paper, we provide a methodological approach for the implementation of a WebGIS necessary for very detailed dynamic mapping and visualization of geospatial coastal data; the description of the dataset necessary for the monitoring of coastal areas, especially the PBs; and a demonstration of a case study for the PBs of Sicily and Malta by using the methodology and the dataset used during the BESS project. Detailed steps involved in the creation of the WebGIS are presented. These include data preparation, data storage, and data publication and transformation into geo-services. With the help of different Open Geospatial Consortium protocols, the WebGIS displays different layers of information for 134 PBs including orthophotos, sedimentological/geomorphological beach characteristics, shoreline evolution, geometric and morphological parameters, shallow water bathymetry, and photographs of pocket beaches. The WebGIS allows not only for identifying, evaluating, and directing potential solutions to present and arising issues, but also enables public access and involvement. It reflects a platform for future local and regional coastal zone monitoring and management, by promoting public/private involvement in addressing coastal issues and providing local public administrations with an improved technology to monitor coastal changes and help better plan suitable interventions.
Cross-border tourism cooperation is a fruitful form of engagement between borderland destinations, helping them boost their profile and minimise problems arising from operating near a border. ...European cross-border tourism cooperation is often supported by a European Union project funding arm known as INTERREG. Our study explores the perceptions and experiences of stakeholders involved in three INTERREG projects between tourism destinations in the Scandinavian borderland region of Jämtland-Trøndelag. The aim of the study is to understand why tourism actors in the region decide to apply for INTERREG funds, what their perceptions are towards the project framework, and how their experiences of INTERREG influence their assessment of the programme as a tool for successful cross-border cooperation in tourism. Emerging from a qualitative approach based on in-depth semi-structured interviews, we reveal that the stakeholders involved in the projects see INTERREG as a valuable source of funding in an otherwise under-funded border region, but that they experience a number of problems within the INTERREG framework. The omnipresence of short-term, supranational funded projects is perceived as detrimental to the establishment of sustainable cross-border tourism development within the study region. We recommend that tourism practitioners be more cautious when thinking of (re)applying for INTERREG funding.
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