The age estimation of the individual by the forensic experts ascertains the chronological age of an individual. The possibility that the person being examined may be younger or older than a certain ...age threshold makes this process crucial, as it will establish whether or not the person is an adult under the law. The aim of this study was to test the applicability of the London Atlas of tooth development and eruption in Nepalese subset population.
The London Atlas for age estimation was tested in 350 digital panoramic radiographs from the patients between four and twenty-four years visiting Tribhuvan University Teaching Hospital, Institute of Medicine, Nepal.
The mean values of the estimated age were higher in both the sexes, which was statistically not significant. Both the sexes showed an excellent positive correlation, and was significant with a p value of <0.001. The age estimation upto 10 years group classification was nearly accurate with less than 1 and 2.5 years variation in males and females respectively. The accuracy was good in 16-18 years group with maximum deviation of ±2.5 years. The accuracy was poor in more than 18 years group, as the variability was more than 5 years.
The London Atlas method was best suited for less than 18 years of age and was not very accurate in the age group of 13-14 and 14-15 years where most of the polymorphisms were noted.
The returned Wallace, Andrew
City (London, England),
11/1/2020, Letnik:
24, Številka:
5-6
Journal Article
Recenzirano
Amid a globalised crisis in secure housing provision, this article zooms in on the specific experiences of older working-class people coping with public housing demolition and forced neighbourhood ...transition in London. London's new-build mixed tenure housing developments provide varying proportions of social rental housing, some of it made available to tenants of the council estate it replaced. This article examines the experiences of older people who have taken up the 'opportunity' of 'return' and explores the multi-faceted work they are forced to undertake as they move into unfamiliar and capricious social, physical and political landscapes superimposed on the collapsed infrastructure of their old estate. The article brings themes of 'un-homing', ageing in place and everyday 'repair' work into encounter and calls for greater qualitative understanding of the 'return' experience as a dimension of forced relocation by housing restructuring and tenurial mixing projects.
Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation.
We investigated ...associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation.
We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239).
We found epigenome-wide significant associations false discovery rate (FDR) p < 0.05 between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p < 0.05). NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression.
NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways. Citation: Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C, Ballereau S, Bellander T, Bousquet J, Bustamante M, Charles MA, de Kluizenaar Y, den Dekker HT, Duijts L, Felix JF, Gehring U, Guxens M, Jaddoe VV, Jankipersadsing SA, Merid SK, Kere J, Kumar A, Lemonnier N, Lepeule J, Nystad W, Page CM, Panasevich S, Postma D, Slama R, Sunyer J, Söderhäll C, Yao J, London SJ, Pershagen G, Koppelman GH, Melén E. 2017. Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure. Environ Health Perspect 125:104-110; http://dx.doi.org/10.1289/EHP36.
Climate change is expected to increase the frequency and duration of hot weather and its associated adverse health effects. In dense urban areas, these phenomena will be exacerbated by the Urban Heat ...Island (UHI) effect and indoor overheating.
This paper assesses population exposure and vulnerability to high summer temperatures by exploring the geospatial connection between the UHI, housing energy efficiency and overheating risk, and social vulnerability indicators, such as income and the elderly population. Focusing on Madrid and London, two European cities with strong UHIs but contrasting drivers of indoor heat risk, the spatial distribution of selected indicators were analysed by means of Geographical Information Systems, and areas with the highest vulnerability towards summer energy poverty were identified.
It was found that while ‘hot and vulnerable’ areas are present in both Madrid and London, there are significant differences in climate, socioeconomic distribution and housing between the two cities. In warmer climates such as Madrid, energy poverty—traditionally defined by wintertime heating—requires its definition to be broadened to include summertime cooling needs; in the context of climate change and urban warming trends, this may soon also be the case in northern cities such as London.
The COVID-19 pandemic has drastically impacted people’s travel behaviour and introduced uncertainty in the demand for public transport. To investigate user preferences for travel by London ...Underground during the pandemic, we conducted a stated choice experiment among its pre-pandemic users (N = 961). We analysed the collected data using multinomial and latent class logit models. Our discrete choice analysis provides two sets of results. First, we derive the crowding multiplier estimate of travel time valuation (i.e., the ratio of the value of travel time in uncrowded and crowded situations) for London underground users. The results indicate that travel time valuation of Underground users increases by 73% when it operates at technical capacity. Second, we estimate the sensitivity of the preference for the London Underground relative to the epidemic situation (confirmed new COVID-19 cases) and interventions (vaccination rates and mandatory face masks). The sensitivity analysis suggests that making face masks mandatory is a main driver for recovering the demand for the London underground. The latent class model reveals substantial preference heterogeneity. For instance, while the average effect of mandatory face masks is positive, the preferences of 30% of pre-pandemic users for travel by the Underground are negatively affected. The positive effect of mandatory face masks on the likelihood of taking the Underground is less pronounced among males with age below 40 years, and a monthly income below 10,000 GBP. The estimated preference sensitivities and crowding multipliers are relevant for supply–demand management in transit systems and the calibration of advanced epidemiological models.
We investigated the prevalence of anosmia and ageusia in adult patients with a laboratory-confirmed diagnosis of infection with severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2).
...This was a retrospective observational analysis of patients infected with SARS-CoV-2 admitted to hospital or managed in the community and their household contacts across a London population during the period March 1st to April 1st, 2020. Symptomatology and duration were extracted from routinely collected clinical data and follow-up telephone consultations. Descriptive statistics were used.
Of 386 patients, 141 (92 community patients, 49 discharged inpatients) were included for analysis; 77/141 (55%) reported anosmia and ageusia, nine reported only ageusia and three only anosmia. The median onset of anosmia in relation to onset of SARS-CoV-2 disease (COVID-19) symptoms (as defined by the Public Health England case definition) was 4 days (interquartile range (IQR) 5). Median duration of anosmia was 8 days (IQR 16). Median duration of COVID-19 symptoms in community patients was 10 days (IQR 8) versus 18 days (IQR 13.5) in admitted patients. As of April 1, 45 patients had ongoing COVID-19 symptoms and/or anosmia; 107/141 (76%) patients had household contacts, and of 185 non-tested household contacts 79 (43%) had COVID-19 symptoms with 46/79 (58%) reporting anosmia. Six household contacts had anosmia only.
Over half of the positive patients reported anosmia and ageusia, suggesting that these should be added to the case definition and used to guide self-isolation protocols. This adaptation may be integral to case findings in the absence of population-level testing. Until we have successful population-level vaccination coverage, these steps remain critical in the current and future waves of this pandemic.
THE BENEFITS OF FORCED EXPERIMENTATION Larcom, Shaun; Rauch, Ferdinand; Willems, Tim
The Quarterly journal of economics,
11/2017, Letnik:
132, Številka:
4
Journal Article
Recenzirano
Odprti dostop
We present evidence that a significant fraction of commuters on the London Underground do not travel on their optimal route. We show that a strike on the Underground, which forcedmany commuters to ...experiment with new routes, brought lasting changes in behavior. This effect is stronger for commuters who live in areas where the Underground map is more distorted, which points to the importance of informational imperfections. Information resulting from the strike improved network efficiency. Search costs alone are unlikely to explain the suboptimal behavior.
This article is based on a study of Docklands in London, which was undertaken as part of a larger study of gentrification in inner London. Using interview and survey data, the article compares ...Docklands with the gentrification that has taken place elsewhere in inner London. Whilst there were important differences between these inner‐London study areas, all differ qualitatively from the process in Docklands. The article questions whether the distinction that is normally drawn between ‘gentrification by capital’ and ‘gentrification by collective social action’ is appropriate and argues that this disguises the nature of the urban regeneration being undertaken in Docklands. It is suggested that this is more a process of re‐urbanization in which some of the characteristics normally associated with suburban development are being brought to an area near the centre of the city, but in a context more normally reserved for gentrification. The data from the survey show that for many of the respondents in Docklands, the kind of life they are seeking is often associated with some conceptions of suburban life. It is suggested that both gentrification and suburbanization as concepts need to be used with care in understanding contemporary processes of re‐urbanization such as are occurring in Docklands and the central areas of other British cities.
Résumé
Cet article s'appuie sur une étude du quartier des Docks de Londres, menée dans le cadre de travaux plus vastes relatifs à l'embourgeoisement du centre londonien. Des données provenant d'entretiens et d'enquêtes permettent une comparaison entre cette zone et d'autres quartiers centraux ayant connu un embourgeoisement. S'il existe d'importantes différences entre ces quartiers du centre‐ville, tous divergent au plan qualitatif du processus des Docks. En s'interrogeant sur la pertinence de la distinction entre ‘embourgeoisement par le capital’ et ‘embourgeoisement par l'action sociale collective’, l'article avance que cette vision dissimule la nature de la régénération urbaine entreprise dans le quartier des Docks. Il s'agit davantage d'un processus de ré‐urbanisation dans lequel des caractéristiques associées habituellement à l'aménagement des banlieues sont apportées dans une zone située près du centre‐ville, bien que dans un contexte plus normalement réservéà l'embourgeoisement. Les résultats d'enquête montrent que, pour bon nombre des personnes interrogées, le genre de vie recherché dans le quartier des Docks se rapproche de certaines conceptions de la vie suburbaine. Il convient donc d'utiliser avec prudence les concepts d'embourgeoisement et de suburbanisation si l'on veut comprendre les processus contemporains de ré‐urbanisation, tels que ceux qui ont lieu dans le quartier des Docks et dans le centre d'autres grandes villes britanniques.
People with low income often experience higher exposures to air pollutants. We compared the exposure to particulate matter (PM1, PM2.5 and PM10), Black Carbon (BC) and ultrafine particles (PNCs; ...0.02–1μm) for typical commutes by car, bus and underground from 4 London areas with different levels of income deprivation (G1 to G4, from most to least deprived). The highest BC and PM concentrations were found in G1 while the highest PNC in G3. Lowest concentrations for all pollutants were observed in G2. We found no systematic relationship between income deprivation and pollutant concentrations, suggesting that differences between transport modes are a stronger influence. The underground showed the highest PM concentrations, followed by buses and a much lower concentrations in cars. BC concentrations in the underground were overestimated due to Fe interference. BC concentrations were also higher in buses than cars because of a lower infiltration of outside pollutants into the car cabin. PNCs were highest in buses, closely followed by cars, but lowest in underground due to the absence of combustion sources. Concentration in the road modes (car and bus) were governed by the traffic conditions (such as traffic flow interruptions) at the specific road section. Exposures were reduced in trains with non-openable windows compared to those with openable windows. People from less income-deprived areas have a predominant use of car, receiving the lowest doses (RDD<1μgh−1) during commute but generating the largest emissions per commuter. Conversely, commuters from high income-deprived areas have a major reliance on the bus, receiving higher exposures (RDD between 1.52 and 3.49μgh−1) while generating less emission per person. These findings suggest an aspect of environmental injustice and a need to incorporate the socioeconomic dimension in life-course exposure assessments.
Display omitted
•No systematic relationship between income deprivation and pollutant level was found.•Modes hierarchy for PM concentrations in London observed as underground≫bus>car.•Highest PNCs were measured in London buses, followed by car and underground train.•BC was 23% higher in London buses than cars and influenced by Fe in underground.•Air quality in trains depended on open/closed windows and above/underground tracks.
Due to the changing demographics of societies around the world, ageing has become a major concern for governments and policy makers alike. What has also become clear is that the older adult consumer ...group and the factors affecting this age group have been studied relatively less in the literature. In this paper, we aim to investigate the adoption, usage, and diffusion of smartphones within the UK older adults so as to identify the factors encouraging or inhibiting smartphone usage and service provision within this age group. To this end, we propose a conceptual framework (Model of Smartphone Acceptance) based on a set of well-known theories of adoption and diffusion. We collected data from 984 participants living in north London and applied the Partial Least Square Structural Equation Modelling (PLS-SEM) technique to analyse the data. Our research can contribute towards reducing some of the existing digital divide within UK older adults. Moreover, businesses can benefit from our research by understanding the significant factors affecting the adoption of smartphones among the UK older population and to adapt their policies accordingly.
PDF
