'I can see this life for exactly what it is. I can now, anyway. We're walkin' a knife edge. One slip, one tiny slip an' we fall. An' there's a fuck of a long way to fall…even for us. An' we're kept ...there…on the knife edge…because they can tell yer which way t'go. Forward or down.' Fin's bright. Some would say gifted. But school isn't going well. While he is busy coping with his mum's depression and his younger brother's drug problem, he can feel his future slipping away. The few jobs that are available in North London are part-time or temporary, and Fin knows his future will be a life of unstable pay, minimal social security benefits, no pension and eroding health care. He is the uture of the emerging major class – living precarious lives at the mercy of the one percent: The Precariat. With his world collapsing slowly around him, Fin finds hope and attraction with the girl at the fried chicken drive-through window. But even she can't offer him a way out. Fin makes one final desperate bid to take control over the future – by giving his brother the chance to turn his life around…
•It is often argued that the popularity of AIM is mainly due to the strict listing requirements in the MM.•During the 1995 to 2010 period, half of AIM listed firms that raised equity in AIM could ...have joined the MM.•This raises the question why firms that meet the heavier regulatory environment of the MM choose the AIM, a lighter regulatory environment.•Using this dataset, we subject this question to a comprehensive investigation and find that the market choice is a self-selection decision.
It is often argued that the popularity of Alternative Investment Market (AIM) in terms of higher number of listings relative to the Main Market (MM) is mainly due to the strict listing requirements in the MM. During the 1995 to 2014 period, 577 out of 1143 AIM listed firms did not qualify for MM listing, but the rest (566) that raised equity in AIM could have joined the MM. This raises the question why firms that meet the heavier regulatory environment of the MM choose the AIM, a lighter regulatory environment. This paper subjects this question to a comprehensive investigation and finds that the market choice is a self-selection decision. The two markets attract companies with different characteristics, and dissimilar post-listing investment and financing priorities. The evidence also shows that smaller and younger companies choose to be listed on the AIM due to lower listing and on-going costs. Heckman Selection models addressing the important question of what would have been the operating performance if AIM companies joined MM indicate that AIM companies would not perform better had they selected to go public in the MM.
Due to the changing demographics of societies around the world, ageing has become a major concern for governments and policy makers alike. What has also become clear is that the older adult consumer ...group and the factors affecting this age group have been studied relatively less in the literature. In this paper, we aim to investigate the adoption, usage, and diffusion of smartphones within the UK older adults so as to identify the factors encouraging or inhibiting smartphone usage and service provision within this age group. To this end, we propose a conceptual framework (Model of Smartphone Acceptance) based on a set of well-known theories of adoption and diffusion. We collected data from 984 participants living in north London and applied the Partial Least Square Structural Equation Modelling (PLS-SEM) technique to analyse the data. Our research can contribute towards reducing some of the existing digital divide within UK older adults. Moreover, businesses can benefit from our research by understanding the significant factors affecting the adoption of smartphones among the UK older population and to adapt their policies accordingly.
Pyrite-permineralized fruits and seeds from the London Clay Formation (Ypresian; England) in the NHMUK are stored in silicone oil to retard decay processes. X-ray micro-computed tomography (micro-CT) ...has revealed internal morphology for multiple holotypes (including severely cracked and encrusted specimens) scanned in the protective fluid. Silicone oil alone has a similar X-ray attenuation to parts of the specimens, causing minor uncertainty for digitally rendered surfaces, but key systematic characters are readily visualized. Further work is needed to optimize visualization of fine-scale cellular detail. Labelling and segmentation to visualize important structures is achievable with these micro-CT datasets. However, manual labelling of individual slices is required, and defining boundaries between features can be difficult due to differential pyritization and silicone oil permeation. Digital sections through specimens can be made in any orientation and digital locule casts can be produced for studies in virtual taphonomy. These achievements have been accomplished with minimal risk to specimens, which remained in silicone oil and were studied within the museum. The datasets provide a potentially permanent record of at-risk specimens, can be made widely available to researchers unable to visit the collections and to other interested parties, and they enable monitoring for future conservation.
The age estimation of the individual by the forensic experts ascertains the chronological age of an individual. The possibility that the person being examined may be younger or older than a certain ...age threshold makes this process crucial, as it will establish whether or not the person is an adult under the law. The aim of this study was to test the applicability of the London Atlas of tooth development and eruption in Nepalese subset population.
The London Atlas for age estimation was tested in 350 digital panoramic radiographs from the patients between four and twenty-four years visiting Tribhuvan University Teaching Hospital, Institute of Medicine, Nepal.
The mean values of the estimated age were higher in both the sexes, which was statistically not significant. Both the sexes showed an excellent positive correlation, and was significant with a p value of <0.001. The age estimation upto 10 years group classification was nearly accurate with less than 1 and 2.5 years variation in males and females respectively. The accuracy was good in 16-18 years group with maximum deviation of ±2.5 years. The accuracy was poor in more than 18 years group, as the variability was more than 5 years.
The London Atlas method was best suited for less than 18 years of age and was not very accurate in the age group of 13-14 and 14-15 years where most of the polymorphisms were noted.
The returned Wallace, Andrew
City (London, England),
11/1/2020, Letnik:
24, Številka:
5-6
Journal Article
Recenzirano
Amid a globalised crisis in secure housing provision, this article zooms in on the specific experiences of older working-class people coping with public housing demolition and forced neighbourhood ...transition in London. London's new-build mixed tenure housing developments provide varying proportions of social rental housing, some of it made available to tenants of the council estate it replaced. This article examines the experiences of older people who have taken up the 'opportunity' of 'return' and explores the multi-faceted work they are forced to undertake as they move into unfamiliar and capricious social, physical and political landscapes superimposed on the collapsed infrastructure of their old estate. The article brings themes of 'un-homing', ageing in place and everyday 'repair' work into encounter and calls for greater qualitative understanding of the 'return' experience as a dimension of forced relocation by housing restructuring and tenurial mixing projects.
Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation.
We investigated ...associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation.
We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239).
We found epigenome-wide significant associations false discovery rate (FDR) p < 0.05 between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p < 0.05). NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression.
NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways. Citation: Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C, Ballereau S, Bellander T, Bousquet J, Bustamante M, Charles MA, de Kluizenaar Y, den Dekker HT, Duijts L, Felix JF, Gehring U, Guxens M, Jaddoe VV, Jankipersadsing SA, Merid SK, Kere J, Kumar A, Lemonnier N, Lepeule J, Nystad W, Page CM, Panasevich S, Postma D, Slama R, Sunyer J, Söderhäll C, Yao J, London SJ, Pershagen G, Koppelman GH, Melén E. 2017. Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure. Environ Health Perspect 125:104-110; http://dx.doi.org/10.1289/EHP36.
Climate change is expected to increase the frequency and duration of hot weather and its associated adverse health effects. In dense urban areas, these phenomena will be exacerbated by the Urban Heat ...Island (UHI) effect and indoor overheating.
This paper assesses population exposure and vulnerability to high summer temperatures by exploring the geospatial connection between the UHI, housing energy efficiency and overheating risk, and social vulnerability indicators, such as income and the elderly population. Focusing on Madrid and London, two European cities with strong UHIs but contrasting drivers of indoor heat risk, the spatial distribution of selected indicators were analysed by means of Geographical Information Systems, and areas with the highest vulnerability towards summer energy poverty were identified.
It was found that while ‘hot and vulnerable’ areas are present in both Madrid and London, there are significant differences in climate, socioeconomic distribution and housing between the two cities. In warmer climates such as Madrid, energy poverty—traditionally defined by wintertime heating—requires its definition to be broadened to include summertime cooling needs; in the context of climate change and urban warming trends, this may soon also be the case in northern cities such as London.
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