An easily separation composite, magnetic chitosan@bismuth tungstate coated by silver (MCTS-Ag/Bi2WO6), was successfully synthesized by the simple hydrothermal method. Moreover, the MCTS-Ag/Bi2WO6 ...demonstrated excellent adsorption/photocatalytic removal of Cu(II) in aqueous solution. Adsorption played a leading role in the synergistic reaction. The catalysts were characterized by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM). The effects on adsorption of Cu(II) were investigated, which included illumination, pH, and initial concentration. The experimental results showed that the theoretical maximum adsorption capacity of Cu(II) (181.8 mg/g) was achieved under simulated solar light irradiation with the optimal pH value of 6.0, indicating that illumination could enhance the adsorption of Cu(II) by MCTS-Ag/Bi2WO6. Meanwhile, the composite exhibited desirable adsorption ability of Cu(II) after 5 cycles. The copper ion adsorption fitted well with pseudo-second-order kinetic model and its isotherm followed Freundlich model.
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•A magnetic composites were synthesized by a simple hydrothermal method, and showed easier separation from water.•In MCTS, the active group –COOH and –OH could complex with Cu(Ⅱ), which could effectively remove Cu(Ⅱ).•The absorbent, MCTS, and the photocatalyst, Ag/Bi2WO6, were combined to improve the adsorption capacity.•MCTS-Ag/Bi2WO6 showed high theoretical adsorption capacity of 181.8 mg/g.
This study uses ANSYS mechanical APDL 19.2 to predict crack propagation trajectories and fatigue crack growth at constant amplitude loading. Mixed-mode fatigue life assessment is implemented by the ...Paris law model for different configuration of modified compact tension specimen (MCTS) in linear elastic fracture mechanics (LEFM). The methodology includes: evaluating stress intensity factors (SIFs), a direction of crack propagationand estimating fatigue life via incremental crack growth process. Predicted crack growth path in the present analysis revealed a change in orientation of the hole proportionately affected fatigue crack life cycles. The propagation of fatigue crack is mostly attracted to the hole and the crack could either curve its path and grow towards it, or bypass the hole and propagate. The mixed-mode fatigue crack path and fatigue crack growth from this study were validated by several crack growth experimental and numerical results in literature.
Cancer is a complex disease that includes the reprogramming of metabolic pathways by malignant proliferating cells, including those affecting the tumor microenvironment (TME). The “TME concept” was ...introduced in recognition of the roles played by factors other than tumor cells in cancer progression. In response to the hypoxic or semi-hypoxic characteristic of the TME, cancer cells generate a large amount of lactate via the metabolism of glucose and glutamine. Export of this newly generated lactate by the tumor cells together with H+ prevents intracellular acidification but acidifies the TME. In recent years, the importance of lactate and acidosis in carcinogenesis has gained increasing attention, including the role of lactate as a tumor-promoting metabolite. Here we review the existing literature on lactate metabolism in tumor cells and the ability of extracellular lactate to direct the metabolic reprogramming of those cells. Studies demonstrating the roles of lactate in biological processes that drive or sustain carcinogenesis (tumor promotion, angiogenesis, metastasis and tumor resistance) and lactate’s role as an immunosuppressor that contributes to tumor evasion are also considered. Finally, we consider recent therapeutic efforts using available drugs directed at and interfering with lactate production and transport in cancer treatment.
•Medium chain triglyceride (MCT) supplementation using a C8:C10 ratio of 30:70 improved cognitive performance in young healthy adults.•Improvements were observed in both 12 g and 18 g MCT/day groups, ...with minimal differences between these two groups.•MCT ingestion improved cognitive performance after 2–3 weeks of supplementation.
The brain can utilise medium chain triglycerides (MCTs) as an alternative fuel to glucose, and research has shown that MCT ingestion improves cognitive function in diseased and/or elderly individuals. The aim of this study is to determine if these improvements can also be observed in young, healthy adults. Furthermore, we aim to establish the ideal dosage and timeframe necessary for an effect.
Participants were divided equally into three groups of 10 (Placebo (0 g), 12 g and 18 g MCT/day) and were supplemented for 4 weeks. The supplement had a C8:C10 ratio of 30:70. Participants visited the laboratory once a week for 5 weeks (baseline, test weeks 1–4) to undergo a battery of cognitive tests; Trail Making, Digit Span, Spatial Span, Covert Shift of Attention, and Rapid Visual Information Processing.
After 2–3 weeks of supplementation, MCT ingestion enhanced performance in cognitive tasks, including: Trail Making A/B and Digit Span Forwards/Backwards (ps<0.001) when compared to a placebo group taking a carbohydrate gel. In Spatial Span Backwards, there was a significant main effect of group (p = 0.002). Where significance was seen, there were main effects of time after 2–3 weeks (ps<0.05). There was minimal difference between the two MCT intervention groups in most measures (ps>0.05). There were also null results in tasks measuring attention and reaction time (ps>0.05).
MCT ingestion improved cognitive performance after 2–3 weeks, with minimal difference between taking 12 g and 18 g MCT/day groups, suggesting a possible dose-response threshold at 12 g MCT/day when supplementing over a short period.
Monocarboxylate transporters in cancer Payen, Valéry L.; Mina, Erica; Van Hée, Vincent F. ...
Molecular metabolism (Germany),
03/2020, Letnik:
33
Journal Article
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Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer cells may use 4 main fuels that are ...shuttled in 5 different metabolic pathways. Glucose fuels glycolysis that can be coupled to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in oxidative cancer cells or to lactic fermentation in proliferating and in hypoxic cancer cells. Lipids fuel lipolysis, glutamine fuels glutaminolysis, and lactate fuels the oxidative pathway of lactate, all of which are coupled to the TCA cycle and OXPHOS for energy production. This review focuses on the latter metabolic pathway.
Lactate, which is prominently produced by glycolytic cells in tumors, was only recently recognized as a major fuel for oxidative cancer cells and as a signaling agent. Its exchanges across membranes are gated by monocarboxylate transporters MCT1-4. This review summarizes the current knowledge about MCT structure, regulation and functions in cancer, with a specific focus on lactate metabolism, lactate-induced angiogenesis and MCT-dependent cancer metastasis. It also describes lactate signaling via cell surface lactate receptor GPR81.
Lactate and MCTs, especially MCT1 and MCT4, are important contributors to tumor aggressiveness. Analyses of MCT-deficient (MCT+/- and MCT−/-) animals and (MCT-mutated) humans indicate that they are druggable, with MCT1 inhibitors being in advanced development phase and MCT4 inhibitors still in the discovery phase. Imaging lactate fluxes non-invasively using a lactate tracer for positron emission tomography would further help to identify responders to the treatments.
•In cancer, hypoxia and cell proliferation are associated to lactic acid production.•Lactate exchanges are at the core of tumor metabolism.•Transmembrane lactate trafficking depends on monocarboxylate transporters (MCTs).•MCTs are implicated in tumor development and aggressiveness.•Targeting MCTs is a therapeutic option for cancer treatment.
•Highlight the power of Monte Carlo Tree Search for cooperative driving planning.•Provide a fast yet effective cooperative driving planning for autonomous vehicles.•Allow lane change of cooperative ...driving vehicles.
This paper studies the cooperative driving of connected and automated vehicles (CAVs) at conflict areas (e.g., non-signalized intersections and ramping regions). Due to safety concerns, most existing studies prohibit lane change since this may cause lateral collisions when coordination is not appropriately performed. However, in many traffic scenarios (e.g., work zones), vehicles must change lanes. To solve this problem, we categorize the potential collision into two kinds and thus establish a bi-level planning problem. The right-of-way of vehicles for the critical conflict zone is considered in the upper-level, and the right-of-way of vehicles during lane changes is then resolved in the lower-level. The solutions of the upper-level problem are represented in tree space, and a near-optimal solution is searched for by combining Monte Carlo Tree Search (MCTS) with some heuristic rules within a very short planning time. The proposed strategy is suitable for not only the shortest delay objective but also other objectives (e.g., energy-saving). Numerical examples show that the proposed strategy leads to good traffic performance in real-time.
Deep level transient spectroscopy (DLTS) and minority carrier transient spectroscopy (MCTS) are used to investigate electrically active defects in commercial SiC Schottky power diodes after heavy-ion ...microbeam irradiation at different voltages. The DLTS and MCTS spectra of pristine samples are analysed and compared to devices showing or not signatures of Single Event Leakage Current (SELC) degradation. An additional peak labelled 'C' with an activation energy of 0.17 eV below the conduction band edge is observed in the DLTS spectra of a sample degraded with SELC.
In this paper, we propose a new cooperative driving strategy for connected and automated vehicles (CAVs) at unsignalized intersections. Based on the tree representation of the solution space for the ...passing order, we combine Monte Carlo tree search (MCTS) and some heuristic rules to find a nearly global-optimal passing order (leaf node) within a very short planning time. Testing results show that this new strategy can keep a good tradeoff between performance and computation flexibility.
Phenotypic heterogeneity of cancer cells, cell biological context, heterotypic crosstalk and the microenvironment are key determinants of the multistep process of tumor development. They sign ...responsible, to a significant extent, for the limited response and resistance of cancer cells to molecular-targeted therapies. Better functional knowledge of the complex intra- and intercellular signaling circuits underlying communication between the different cell types populating a tumor tissue and of the systemic and local factors that shape the tumor microenvironment is therefore imperative. Sophisticated 3D multicellular tumor spheroid (MCTS) systems provide an emerging tool to model the phenotypic and cellular heterogeneity as well as microenvironmental aspects of in vivo tumor growth. In this review we discuss the cellular, chemical and physical factors contributing to zonation and cellular crosstalk within tumor masses. On this basis, we further describe 3D cell culture technologies for growth of MCTS as advanced tools for exploring molecular tumor growth determinants and facilitating drug discovery efforts. We conclude with a synopsis on technological aspects for on-line analysis and post-processing of 3D MCTS models.
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