Books about Oxford have generally focused on the University rather than the city. This original book on the local politics of Oxford City from 1830 to 1980 is based on a comprehensive analysis of ...primary sources and tells the story of the city’s progressive politics. The book traces this history from Chartism and electoral reform in the mid-nineteenth century, through the early years of socialism to the impact of communism in the interwar period, the struggle between nuclear disarmers and Gaitskellites in the 1960s and the impact of the new revolutionary left in the late 1970s. Throughout the narrative, the book contrasts the two approaches of those engaged in progressive politics, those who focused on the politics of reform and improved government and those who preferred the politics of revolt, protest and revolutionary rhetoric. The author argues that a central feature of this history has been the co-existence and interaction of working- and middle- class elements. It rediscovers a rich heritage, a fascinating story and offers a rare wide-ranging chronological narrative of local UK city politics. Through its extensive quotes from primary sources, the book presents a vivid picture of local politics over 150 years.
Oxford, the home of lost causes, the epitome of the world of medieval and renaissance learning in Britain, has always fascinated at a variety of levels: social, institutional, cultural. Its rival, ...Cambridge, was long dominated by mathematics, while Oxford's leading study was Classics. In this pioneering book, 16 leading authorities explore a variety of aspects of Oxford Classics in the last two hundred years: curriculum, teaching and learning, scholarly style, publishing, gender and social exclusion and the impact of German scholarship. Greats (Literae Humaniores) is the most celebrated classical course in the world: here its early days in the mid-19th century and its reform in the late 20th are discussed, in the latter case by those intimately involved with the reforms. An opening chapter sets the scene by comparing Oxford with Cambridge Classics, and several old favourites are revisited, including such familiar Oxford products as Liddell and Scott's "Greek-English Lexicon", the "Oxford Classical Texts", and Zimmern's "Greek Commonwealth". The book as a whole offers a pioneering, wide-ranging survey of Classics in Oxford.
Less than two months before he was assassinated, Malcolm X spoke at the Oxford Union—the most prestigious student debating organization in the United Kingdom. The Oxford Union regularly welcomed ...heads of state and stars of screen and served as the training ground for the politically ambitious offspring of Britain’s better classes. Malcolm X, by contrast, was the global icon of race militancy. For many, he personified revolution and danger. Marking the fiftieth anniversary of the debate, this book brings to life the dramatic events surrounding the visit, showing why Oxford invited Malcolm X, why he accepted, and the effect of the visit on Malcolm X and British students. Stephen Tuck tells the human story behind the debate and also uses it as a starting point to discuss larger issues of Black Power, the end of empire, British race relations, immigration, and student rights. Coinciding with a student-led campaign against segregated housing, the visit enabled Malcolm X to make connections with radical students from the Caribbean, Africa, and South Asia, giving him a new perspective on the global struggle for racial equality, and in turn, radicalizing a new generation of British activists. Masterfully tracing the reverberations on both sides of the Atlantic, Tuck chronicles how the personal transformation of the dynamic American leader played out on the international stage.
We propose LongQC as an easy and automated quality control tool for genomic datasets generated by third generation sequencing (TGS) technologies such as Oxford Nanopore technologies (ONT) and SMRT ...sequencing from Pacific Bioscience (PacBio). Key statistics were optimized for long read data, and LongQC covers all major TGS platforms. LongQC processes and visualizes those statistics automatically and quickly.
Patient-reported outcome scores are the mainstay method for quantifying success following arthroplasty. However, it is unclear when a “successful outcome” is achieved. We calculated threshold values ...for the Oxford Hip and Knee Score (OHS and OKS) representing achievement of a successful treatment at 12-month follow-up.
Questionnaires were administered to patients undergoing total hip (THA) or knee (TKA) arthroplasty before and 12 months after surgery alongside questions assessing key aspects of treatment success. A composite success criterion was used to perform receiver operator characteristic analysis. Thresholds providing maximum sensitivity and specificity were determined for the total sample and subgroups defined by presurgery scores.
Data were available for 3203 THA and 2742 TKA patients. Applying the composite treatment success criterion, 67.3% of the TKA and 77.6% of the THA sample reported treatment success. Accuracy for predicting treatment success was high for the OHS and OKS (both areas under the curve, 0.87). For the OHS, a threshold value of 37.5 points showed highest sensitivity and specificity in the total sample, while for the OKS the optimal threshold was 32.5 points. Depending on presurgery scores, optimal thresholds varied between 32.5 and 38.5 for the OHS and 28.5 and 36.5 for the OKS.
This is the first study to apply a composite “success” anchor to the OHS and OKS to evaluate outcome following total joint arthroplasty. Notably fewer patients report a “successful outcome” using a composite outcome threshold than report being “satisfied.”
•Direct sequencing of native RNA molecules using Oxford Nanopore Technologies enabled straight inspection of RNA modifications, and offered a promising alternative solution.•N6-methyladenosine is ...known to cause characteristic changes and increased base call errors of ONT signals compared with non-modified adenosines, based on which, the m6A sites can be identified directly from ONT signals.•Using the m6A sites revealed by Illumina technology as benchmark, we showed that, the accuracy of ONT-based m6A site prediction can be further increased by integrating additional information from the primary sequences of RNA (AUROC of 0.918), compared with using ONT signals only (AUROC 0.878 using Base call error features, and 0.804 using Tombo features).•Our method provides a new perspective for more reliable mining of the relatively noisy ONT signals.
Traditional epitranscriptome profiling approach relies on specific antibodies or chemical treatments to capture modified RNA molecules and then applies high throughput sequencing to identify their transcriptomic locations. However, due to the lack of suitable or high-quality antibodies, only a small proportion of the 170 documented RNA modifications were profiled with those approaches. Direct sequencing of native RNA molecules using Oxford Nanopore Technologies (ONT) enabled straight inspection of RNA modifications and offered a promising alternative solution. N6-methyladenosine (m6A) is known to cause characteristic changes and increased base call errors of ONT signals compared with non-modified adenosines, based on which, the m6A sites can be identified directly from ONT signals. Meanwhile, a number of studies have shown that it is possible to predict m6A sites from RNA primary sequences. Using the m6A sites revealed by Illumina technology as benchmark, we showed that, the accuracy of ONT-based m6A site prediction can be further increased by integrating additional information from the primary sequences of RNA (AUROC of 0.918), compared with using ONT signals only (AUROC 0.878 using Base call error features, and 0.804 using Tombo features), providing a new perspective for more reliable mining of the relatively noisy ONT signals.
Background: Given the demonstrated utility of Third Generation Sequencing Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) long reads in many studies, a comprehensive analysis and ...comparison of their data quality and applications is in high demand.
Methods: Based on the transcriptome sequencing data from human embryonic stem cells, we analyzed multiple data features of PacBio and ONT, including error pattern, length, mappability and technical improvements over previous platforms. We also evaluated their application to transcriptome analyses, such as isoform identification and quantification and characterization of transcriptome complexity, by comparing the performance of size-selected PacBio, non-size-selected ONT and their corresponding Hybrid-Seq strategies (PacBio+Illumina and ONT+Illumina).
Results: PacBio shows overall better data quality, while ONT provides a higher yield. As with data quality, PacBio performs marginally better than ONT in most aspects for both long reads only and Hybrid-Seq strategies in transcriptome analysis. In addition, Hybrid-Seq shows superior performance over long reads only in most transcriptome analyses.
Conclusions: Both PacBio and ONT sequencing are suitable for full-length single-molecule transcriptome analysis. As this first use of ONT reads in a Hybrid-Seq analysis has shown, both PacBio and ONT can benefit from a combined Illumina strategy. The tools and analytical methods developed here provide a resource for future applications and evaluations of these rapidly-changing technologies.
Deixis Analysis on Oxford University E-mail Messages Nur Azizah, Desi; Sabat, Yuliyanto; Musyarofah, Lailatul ...
Journal of English Language Teaching and Literature,
03/2024, Letnik:
5, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Deixis is essential to creating effective communication. This research aimed (i) to determine the number of each type of deixis contained within E-mails from Oxford University Publications Office and ...(ii) the meanings contained there in. This research used qualitative descriptive method. The basic theory used by researchers is the theory of Yule. Yule described deixis as divided into 3, namely person, spatial, and temporal.The data used in this study came from one of the sources who received an E-mail from Oxford University and interview data. The result of the research was there are 2 types of deixis in E-mail, namely person deixis and spatial deixis. In person deixis was found 29 data with 3 forms of pronouns, namely You, Your, We, Our, Us, Their, and It. In spatial deixis was found 3 data with 2 forms, namely below and this. From the interview data, the researchers found that the language used in international campuses generally easy to comprehend, particularly noting the helpfulness of deixis in grasping message meanings, albeit sometimes requiring repeated reading for full understanding, with messages from Oxford University being notably straightforward.
Basecalling, the computational process of translating raw electrical signal to nucleotide sequence, is of critical importance to the sequencing platforms produced by Oxford Nanopore Technologies ...(ONT). Here, we examine the performance of different basecalling tools, looking at accuracy at the level of bases within individual reads and at majority-rule consensus basecalls in an assembly. We also investigate some additional aspects of basecalling: training using a taxon-specific dataset, using a larger neural network model and improving consensus basecalls in an assembly by additional signal-level analysis with Nanopolish.
Training basecallers on taxon-specific data results in a significant boost in consensus accuracy, mostly due to the reduction of errors in methylation motifs. A larger neural network is able to improve both read and consensus accuracy, but at a cost to speed. Improving consensus sequences ('polishing') with Nanopolish somewhat negates the accuracy differences in basecallers, but pre-polish accuracy does have an effect on post-polish accuracy.
Basecalling accuracy has seen significant improvements over the last 2 years. The current version of ONT's Guppy basecaller performs well overall, with good accuracy and fast performance. If higher accuracy is required, users should consider producing a custom model using a larger neural network and/or training data from the same species.
A shortage of affordable new housing, builders choosing to build larger, more profitable houses, and a diminishing stock of cheap houses for rent. All this sounds very familiar today, but at the end ...of the Great War, scarcely any houses had been built for four years and there was political pressure to build ‘Homes for Heroes’, impelled to a degree by fear of revolution. Council housing, supported by central government funding, was the chosen solution in 1919, and this study by Malcolm Graham, a leading Oxford local historian for many years, examines the consequences in Oxford, then a university city on the cusp of change. Behind the city’s Dreaming Spires image, housing for the working population was already in short supply, but an economy-minded and largely non-political City Council had always been reluctant to intervene in the housing market. In 1919, there was no hint of the city’s industrial future, and the City Council saw the replacement of substandard houses as its main challenge. The meteoric rise of the local motor industry in the early 1920s led to rapid population growth and created a massive new demand for cheap housing. Dr Graham examines the uneasy partnership between the City Council and Whitehall which led to the building of over 3,000 council houses in Oxford between the Wars. The provision of these ‘wholesome dwellings’ was a substantial, and lasting, achievement, but private builders were in fact catering for most housing need in and around the city by the 1930s. The notorious Cutteslowe Walls, built to exclude council tenants from an adjoining private estate, reflected the way in which the growing city was being socially segregated. Dr Graham provides a fascinating insight into how modern Oxford evolved away from the university buildings and college quadrangles for which the city is internationally renowned.
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