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Provider: - Institution: - Data provided by Europeana Collections- - All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Prispevek obravnava rezultate zaščitnih arheoloških raziskav v Fizinah leta 1998, med katerimi so bili v manjši sondi dokumen-tirani ostanki večfazne rimske arhitekture in spremljajočih plasti z ...drobno materialno kulturo. ostanki najverjetneje pripadajo manjši naselbini s pristaniščem, ki dopolnjuje podobo piranskega zaledja v času med sredino 1. stoletja pr. n. št. in poznorimskim obdobjem. Nezadostno dokumentirano najstarejšo fazo ozna-čujejo keramika s črnim premazom, amfore in grobo posodje, najverjetneje v zvezi z bankino iz masivnih kamnov. Na konec 1. in v 2. stoletje sodijo zidovi večjega objekta s pripadajočimi najdbami, med katerimi izstopa egejsko posodje. Naselbina doživi višek v času med 4. in prvo polovico 5. stoletja, kamor poleg arhitekture sodijo številni odlomki amfor in namiznega posodja afriške produkcije, novci ter ladjedelniški in ribiški pribor. Po-datke iz raziskav na kopnem dopolnjuje dobro ohranjen objekt z dvema zaprtima bazenoma, ki se nahaja na morskem dnu ob zahodnem robu drage. Glede na njegove dimenzije, gradbene primerjave iz istre in širše okolice ter prisotnost izvira sladke vode sklepamo, da gre za ribogojnico s pomoli oz. operativno obalo za pristajanje ladij.
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
The aim of this work was to synthesize steroidal heterocycles and to elucidate the potential role of these compounds as antimicrobial agents. The synthesis of steroidal heterocycles containing the ...pyrazole, isoxazole, thiazole, pyrane, pyridine, pyridazine, or benzopyrane ring attached to the pregnene nucleus is reported. Progesterone (1) reacts with dimethyl formamide dimethyl acetal to form enamine 2. Heterocyclization of 2 with hydrazines, hydroxylamine, glycine, ethyl acetoacetate or cyanomethylene afforded novel steroidal heterocyclic derivatives. The in vitro antimicrobial evaluation showed that all synthesized compounds show activity against the used strains of Gram positive bacteria and fungi.
U radu je opisana sinteza steroidnih heterocikličkih spojeva i evaluacija njihovog antimikrobnog djelovanja. Sintetizirani spojevi sadrže pirazol, izoksazol, tiazol, piran, piridin, piridazin ili benzopiran na pregnenskoj jezgri. Progesteron (1) je prvo u reakciji s dimetil formamid dimetil acetalom dao enamin 2. Novi steroidni heterociklički derivati dobiveni su heterociklizacijom spoja 2 s hidrazinima, hidroksilaminom, glicinom, etilacetoaceatom i cijanometilenom. Antimikrobno vrednovanje in vitro pokazalo je da su svi sintetizirani spojevi aktivni protiv testiranih Gram pozitivnih bakterija i gljivica.
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