Starting from N-substituted indole-3-carboxaldehydes (1a-g) a series of new 3-(N-substituted indol-3-yl)methyleneamino-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles (3a-g and 4a-g) have been ...synthesized via the acid catalyzed condensation reaction of 1a-g with 3-amino-5-pyrazolone, followed by the reaction with arylidene malononitriles. A series of new 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles (7a-g) have been prepared either via the base catalyzed condensation reaction of 1a-g with 3-amino-5-pyrazolone to give 6a-g, followed by the reaction with malononitrile or by the reaction of N-substituted-3-indolylidene malononitriles (5a-g) with 3-amino-5-pyrazolone. According to the obtained results, the newly synthesized compounds possess significant anti-inflammatory, analgesic and anticonvulsant activities. The anticonvulsant potency of certain tested compounds was more pronounced than both anti-inflammatory and analgesic activities. Moreover, most of the newly synthesized compounds possess potential antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa.
U radu se opisuje sinteza novih 3-N-supstituiranih indol-3-il)metilenamino6-amino-4-aril-pirano(2,3-c) pirazol-5-karbonitrila (3a-g i 4a-g) kiselo-kataliziranom kondenzacijom N-supstituiranih indol-3-karboksaldehida (1a-g) s 3-amino-5-pirazolonom iza koje slijedi reakcija s ariliden malononitrilom. Serija novih 3,6-diamino-4-(N-supstituiranih indol-3-il)pirano(2,3-c)pirazol-5-karbonitrila (7a-g) sintetizirana je reakcijom malononitrila s produktima 6a-g, koji su pripravljeni bazno-kataliziranom kondenzacijom 1a-g s 3-amino-5-pirazolonom. Neki spojevi iz serije 7a-g dobiveni su reakcijom N-supstituiranih 3-indolidin malononitrila (5a-g) s 3-amino-5-pirazolonom. Novosintetizirani spojevi imaju značajno protuupalno, analgetsko i antikonvulzivno djelovanje. Antikonvulzivno djelovanje pojedinih testiranih spojeva bilo je jače izraženo nego protuupalno i analgetsko djelovanje. Većina ispitivanih spojeva pokazuje antimikrobno djelovanje na Escherichia coli i Pseudomonas aeruginosa.
The subject of this publication is a critical edition of the preserved parts of the eleventh, twelfth, fourteenth, and sixteenth notary books from the Piran Branch Office of the Regional Archives of ...Koper. With notary books we are not dealing with literary readings, but with abstracts of a mass of business manuscript agreements of various contents. The fragments contain the models of documents created in the period 1301–1320 (1321). The writer of summaries in the preserved fragments of notary fascicle No. 11 was Almericus, while the notary Perinus Appolonii kept records of business transactions in codex No. 15. The writers of other fragments are not known.
The monograph presents different names of Piran Bay (Slo. Piranski zaliv) over time. Despite the leading onomastic topic, the publication is designed as a regional-geographic review of Piran Bay and ...its hinterland, where all the main physical- and socio-geographical characteristics are presented. This book describes the basic hydro-geographic characteristics of Piran Bay as a part of Gulf of Trieste and the Adriatic Sea. The monograph talks about the historical development, salt making in Sečovlje salt pans and the circumstances that led to the now more than two decades-long border dispute between Slovenia and Croatia. A significant chapter is dedicated to the presentation of the different naming of the Bay of Piran through time. According to the chronological order, 104 different cartographic sources present the name changes of the Piran Bay through time and when a certain specific geographic name appeared. Based on media analysis, one of the chapters describes the relation between the names Savudrijska vala or Savudrijski zaljev (Savudrija Bay) and Piranski zaliv or Piranski zaljev (Piran Bay).
With notary books we are not dealing with literary readings, but with abstracts of a mass of business manuscript agreements of various contents. The subject of this publication is the preserved parts ...of the third, ninth, and tenth notary fascicles from the Piran Branch Office of the Regional Archives of Koper. The fragments contain the models of documents created in the period 1284–1296. The authors of summaries in the preserved fragments of notary fascicles are Facina Grimaldi, Facina (Vitali?) and Francisscus de Malonbris.
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Interviste e commenti sulla storia, tradizioni, bellezze naturalistiche e artistiche del dell'Istria slovena. ...Commento focalizzata su Capodistria, ricca di monumenti e delle arti dal medioevo città, il rinascimentale e barocco. Viste del centro storico e la chiesa romanica di Santa Trinità con l'affresco "Danza Macabra". Vedute di Isola, città natale del musicista Giuseppe Tartini che aveva un quadrato costruito in suo nome. Vedute di Pirano, con la marina e il duomo.- Information:- History, traditions, naturalistic and artistic beauties of the Slovene Istria. Capodistria, city full of monuments and arts from the middle-age.- Original language summary:
Storia, tradizioni bellezze naturali e artistiche dell' Istria Slovena, Capodistria, citta' ricca di monumenti e arte della mittle europa.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
The work is a critical edition of the preserved fragments of five notary codices from Piran (1289–1305) with notes made by the notary Dominicus Petenarius. Notaries entered into notary codices the ...essential features of business transactions in stenographic form, specific writing and simple Latin. This is a valuable type of sources for the study of medieval and later history. The entries portray the economic and social life of cities and their surroundings, their administration, judicial system, everyday life, population development, urban image, as well as culture and arts, all of which serve the purposes of research conducted by experts in various fields. The edition is equipped with a standard critical apparatus and an accompanying study which is also translated into English. The main part of the text encompasses the transliteration of the manuscript comprising 518 agreements with different contents. Each is marked with a successive number, defined with regard to its content and dated. The specific features of the original and inconsistencies in writing are described in notes. The work comes with an index of names, a subject index and a list of entries in which each entry is marked with the original annotation of the page in the original, date, type of contents, short summary of the contents and the page in the publication.
The work is a critical edition of the notary codex from Piran (1298–1317). Notaries entered into notary codices the essential features of business transactions in stenographic form, specific writing ...and simple Latin. This is a valuable type of sources for the study of medieval and later history. The entries portray the economic and social life of cities and their surroundings, their administration, judicial system, everyday life, population development, urban image, as well as culture and arts, all of which serve the purposes of research conducted by experts in various fields. The edition is equipped with a standard critical apparatus and an accompanying study which is also translated into English. The main part of the text encompasses the transliteration of the manuscript comprising 420 agreements with different contents. Each is marked with a successive number, defined with regard to its content and dated. The specific features of the original and inconsistencies in writing are described in notes. The work comes with an index of names, a subject index and a list of entries in which each entry is marked with the original annotation of the page in the original, date, type of contents, short summary of the contents and the page in the publication.
The third volume of The Notary Book from Piran is a scientific issue of the source – the book of the notary Sclavion with imbreviations of 589 documents of various contents, which is kept at the ...Piran Archives. It contains the transcription of the original Latin text, notes, an index of personal and place names, a factual register, and a list of summaries of entries.
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
U radu se opisuje sinteza novih 3-(N-supstituiranih indol-3-il)metilenamino-6-amino-4-aril-pirano(2,3-c) pirazol-5-karbonitrila (3a-g i 4a-g) kiselo-kataliziranom kondenzacijom N-supstituiranih ...indol-3-karboksaldehida (1a-g) s 3-amino-5-pirazolonom iza koje slijedi reakcija s ariliden malononitrilom. Serija novih 3,6-diamino-4-(N-supstituiranih indol-3-il)pirano(2,3-c)pirazol-5-karbonitrila (7a-g) sintetizirana je reakcijom malononitrila s produktima 6a-g, koji su pripravljeni bazno-kataliziranom kondenzacijom 1a-g s 3-amino-5-pirazolonom. Neki spojevi iz serije 7a-g dobiveni su reakcijom N-supstituiranih 3-indolidin malononitrila (5a-g) s 3-amino-5-pirazolonom. Novosintetizirani spojevi imaju značajno protuupalno, analgetsko i antikonvulzivno djelovanje. Antikonvulzivno djelovanje pojedinih testiranih spojeva bilo je jače izraženo nego protuupalno i analgetsko djelovanje. Većina ispitivanih spojeva pokazuje antimikrobno djelovanje na Escherichia coli i Pseudomonas aeruginosa.
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