Trusted Platform Module (TPM) is considered to be one of the best technologies to ensure computer system security at present, but it has some defects. The TPM chip exposed on the motherboard is ...easily monitored or bypassed. As a slave device on the bus, it is under the control of the master device and has no higher privileges to access system resources than the CPU used only to compute in traditional computers. The current trusted computing architecture cannot ensure that the TPM chip starts to work prior to the CPU. To solve these problems, this paper propose a new trusted computing dual-architecture, which is made up of a trusted computing subsystem and a traditional computing subsystem. A new hardware root-of-trust and a kind of boot process in the trusted computing dual-architecture are implemented to provide a higher-level trust for the whole system. In a word, the new trusted computing dual-architecture ensures that the hardware root-of-trust is a trusted source due to its dual-architecture design and trusted boot process. It can effectively introduce and set up a trusted chain for the whole computer system. Active-defense capabilities obtained can ensure system security to avoid those defects in previous trusted computing.
Overall Equipment Effectiveness (OEE) is one of the tools to enhance the effectiveness of the utilization rate of machinery and equipment in Total Productive Maintenance (TPM). TPM is a principle of ...management to improve productivity and efficiency of the production company to use the machine effectively. This study measures the value of OEE on gas turbine engine Centaur 50 C3344 which held on operation and maintenance section in PT Perta Samtan Gas Kilang Ekstraksi NGL Prabumulih in the period, followed by analyzing the value of using Pareto analysis of the results obtained by the root causes of the OEE. The conclusion that the value of the analysis results obtained on average exceeded the standard value of OEE 85.63% from 85%, even though in one period the value of OEE less than standard (22.63%). Factors that may experience rapid drop predicted loss is breakdown losses 382 hours (46.53%) and idling minor stoppages 373 hours (45.43), reduce speed 48 hours or 5.85%, rework losses 13 hours or 1.58%, and set up and adjustment losses 5 hours or 0.61%. As a result of which may not have an impact in a short time, but will immediately attack the machine if there is no treatment of maintenance as continuously and directly.
•Current ulcerative colitis (UC) diagnosis is mainly based on biopsy-pathology, while distinguishing between acute and chronic stages of UC is difficult using only biopsies.•Two-photon microscopy ...(TPM) can achieve deeper tissue penetration and provide real-time three-dimensional mucosal histological images.•Moxifloxacin can label pertinent structures in colon tissues, and examination of labeled tissues by TPM can then aid in diagnosis.•This is established in a murine model and awaits clinical validation.
Accurate diagnosis of patients with ulcerative colitis (UC) can reduce their risk of developing colorectal cancer. This study intended to explore whether moxifloxacin, an agent with fluorescence potential, could promote two-photon microscopy (TPM) diagnosis for mice with dextran sodium sulfate (DSS)-induced colitis, which could imitate human UC.
32 Balb/c mice were randomly divided into 4 groups: control, acute colitis, remission colitis and chronic colitis. Fluorescence parameters, imaging performance, and tissue features of different mouse models were compared under moxifloxacin-assisted TPM and label-free TPM.
Excitation wavelength of 720 nm and moxifloxacin labeling time of 2 min was optimal for moxifloxacin-assisted TPM. With moxifloxacin labeling for colonic tissues, excitation power was decreased to 1/10 of that without labeling while fluorescence intensity was increased to 10-fold of that without labeling. Photobleaching was negligible after moxifloxacin labeling and moxifloxacin fluorescence kept stable within 2 h. Compared with the control group, moxifloxacin fluorescence was reduced in the three colitis groups (P < 0.05). Meanwhile, the proportion of enhanced moxifloxacin fluorescence regions was (22.4 ± 1.6)%, (7.7 ± 1.0)%, (13.5 ± 1.7)% and (5.0 ± 1.3)% in the control, acute, remission and chronic groups respectively, with significant reduction in the three colitis groups (P < 0.05). Besides, variant tissue features of experimental colitis models were presented under moxifloxacin-assisted TPM, such as crypt opening, glandular structure, adjacent glandular space and moxifloxacin distribution.
With unique biological interaction between moxifloxacin and colonic mucosa, moxifloxacin-assisted TPM imaging is feasible and effective for accurate diagnosis of different stages of experimental colitis.
Phosphorylated tocopherols are a new class of lipid excipients that have demonstrated potential in pharmaceutical applications. Their ability to solubilise poorly water soluble drugs indicates their ...potential utility in improving bioavailability of drugs where solubility limits their bioavailability. In this study a commercial mixture of phosphorylated tocopherols, TPM was combined with medium chain triglyceride (MCT) as a formulation for CoQ10, and in vitro and in vivo performance compared to the effect of addition of alternative tocopherol-based excipients. In in vitro digestion experiments, CoQ10 was poorly solubilised in the digesting MCT as anticipated. Addition of TPM facilitated the enhanced solubilisation of CoQ10 as did vitamin E TPGS (TPGS). Other tocopherol derivatives (tocopherol acetate, tocopherol) were less effective at solubilising the active during the digestion process. The trends in in vitro solubilisation were conserved in the in vivo bioavailability of CoQ10 after oral administration to rats, with TPM and TPGS formulations providing approximately double the exposure of MCT alone, while the addition of the other tocopherol derivatives reduced the overall exposure. Collectively, the results indicate potential of TPM as a new solubilising excipient for use in oral drug delivery for poorly water soluble drugs.
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•This paper provides 5S methodology implementation experiences in engineering labs.•In this project we look for achieving profitability and an operating costs reduction.•Seven ...indicators have been used in order to verify the success of the methodology.•The 5S panel reflects the information for programming activities and responsibilities.•The results show that the activities are performed in less time and high safety.
This article examines the experience in 5S methodology implementation in order to optimize the work and safety of the university engineering laboratories, in such a way that the results obtained can be extended to other, similar centers. The research project developed has created an organization culture of all resources in the practice laboratories. A working model was defined to create a 5S structure and an implementation process has been established. With the 5S methodology implementation, the school laboratories have become industrial laboratories; they have been adapted to the conditions of security and organization that are usually found in the metalworking industry. Learning, control and maintenance of the resources and activities involved are performed in less time and with a considerable reduction of cost. There is also an increase in available space available for the location of the resources.
Cigarette smoke contains abundant toxicants, and profiling its cytotoxicity represents a critical topic. In this study, cell-substrate impedance sensing (ECIS) was used to measure the cytotoxicity of ...4‑(methylnitrosoamino)‑1‑(3‑pyridinyl)‑1‑butanone (NNK), nicotine, and the total particle material (TPM) of high-tar and low-tar cigarettes on CHO-K1 cells. Normalized impedance values at 3174Hz were collected with microscopic imaging as an assistant, showing the dynamics of cell damage and the ability for cell self-recovery. The NI determination of the four toxicants indicated that, as the concentration of toxicants increased, cigarette smoke produced more intense toxic effects on the cells, and the ability of cell self-recovery worsened until there was permanent damage to the cells and the cells eventually died. Furthermore, the survival rate of the cells was obtained during treatment. NRU assays as a comparison were developed for evaluating the cytotoxicity by calculating the IC50. Both methods showed that the cytotoxicity decreased in the following order: the TPM of high-tar cigarettes, TPM of low-tar cigarettes, nicotine and NNK. The sensitivity of the ECIS method was higher. Our work provides a useful and convenient approach for determining the cytotoxicity of cigarettes in a real-time, label-free manner, contributing to the development of low-toxicity cigarettes.
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•ECIS was employed to assess the cytotoxicity of four toxicants on CHO-K1 cells.•ECIS was used to assess cell self-recovery after poisoning.•Cell viability rates and IC50 values were obtained by NI values and NRU assays.
Purpose
The purpose of this paper is to identify the key enabler for total productive maintenance (TPM) implementation in Indian small and medium enterprises (SMEs) by using graph theoretic approach ...(GTA). There are certain enablers for TPM implementation which helps the organization to implement it successfully. It is very essential to identify the nature and impact of these key enablers.
Design/methodology/approach
A large number of the enablers (27) have identified for TPM implementation in Indian SMEs from the available literature, questionnaire survey and expert opinion. These TPM enablers have categorized into six major categories.
Findings
In this research work, the intensity of identifying enablers has been calculated to show their impact or influence in TPM implementation. The value of intensity of TPM enablers shows the role or impact of individual enabler in the implementation of TPM in Indian SMEs.
Practical implications
This study provides an easy-to-use methodology for the practical decision makers in the manufacturing industry to improve their performance by implementing TPM in Indian SMEs. A detailed methodology has prepared to identify the enablers for TPM implementation in Indian SMEs by using GTA. This study also explains that how to check the feasibility of an organization to implement TPM in Indian SMEs successfully.
Originality/value
TPM is an improvement concept which holds the potential to improve manufacturing organizations, but its implementation is not easy in Indian SMEs. The reason behind the unsuccessful implementation of TPM in most of the organizations is the ignorance of impact of innumerable enablers and barriers.
Conduct of the mouse lymphoma assay (MLA) is underpinned by Organisation for Economic Co-operation and Development (OECD) Test Guideline 490 and International Conference on Harmonisation S2(R1) ...guidance and is a recognised in vitro genotoxicity test battery assay. It has been used on a limited number of occasions for the assessment of some tobacco and nicotine products, such as e-cigarettes and tobacco heating products (THP). The aim of this study was to assess the suitability of the MLA for genotoxicity testing with a variety of tobacco and nicotine products.
Total particulate matter (TPM) from a 3R4F cigarette was compared against a commercial electronic cigarette liquid (e-liquid), electronic cigarette (e-cigarette) aerosol matter captured from the same e-liquid, and TPM from a commercial THP. Treatment conditions included 3 h exposures with and without metabolic activation and a longer 24 h exposure without metabolic activation (-S9) at concentrations up to 500 μg/mL.
Under all treatment conditions, 3R4F produced a clear positive response with regard to induction of mutation. In contrast, no marked induction of mutation was observed for the e-liquid, e-cigarette aerosol or THP. Additionally, data are presented as a function of nicotine equivalents for comparisons between these different tobacco products and test matrices.
•Cigarette was compared against a commercial e-liquid, e-cigarette, a commercial THP.•Data are presented as a function of nicotine equivalents for comparisons between different test matrices and products.•This manuscript is Part One of a Two-Part series detailing the toxicological evaluation of the same test articles.•Under all treatment conditions, 3R4F produced a clear positive response.•In contrast, no marked induction of mutations was observed for e-liquid, e-cigarette aerosol or THP test articles.
•Solubility of topiramate (TPM) in fourteen mono-solvents was measured.•Molecular simulation was applied to investigate the micro-mechanism of TPM-solvents.•Five thermodynamic models were used to ...regressed the solubility data of TPM.•Thermodynamic properties were obtained to better understand the process of TPM dissolution.
A novel antiepileptic drug of topiramate (TPM) has remarkably boosted the human health to against epilepsy. Herein, the solubility of TPM was measured in fourteen mono-solvents through a method of laser monitoring at temperatures from 278.15 to 323.15 K in this work. Moreover, the electrostatic potential surfaces and quantum chemistry calculation at molecular level were applied to explain the solubility differences. The multiple factors such as the polarity of solvent, active sites interaction, the molecular size and free volume all affect the solubility of TPM. Not only the solubility data of TPM were obtained, but also the thermodynamic properties of TPM in various solvents were studied. The solid–liquid phase equilibrium solubility of TPM was regressed and corrected by five thermodynamic models including λ-h, NRTL, NRTL-SAC, UNIQUAC models and modified Apelblat equation, and the classical van't Hoff equation was employed to analyze the thermodynamic properties during the process of TPM dissolution. This research will provide basic data for the production of TPM in the pharmaceutical industry.
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