The objective was to present the results of surveillance of prion diseases in Slovenia that was established in 1996 and then to assess the interdisciplinary approach according to the algorithm of ...case management and reporting data to the National Register at the National Institute of Public Health.
A descriptive study of Creutzfeldt-Jakob disease (CJD) recorded in the period from 1996 to 2017 was carried out.
A total of 123 cases of prion disease were notified between 1996 and 2017. Out of these, 68 were recorded and confirmed by autopsy as sporadic CJD with an average incidence rate of 1,5 cases per million population per year. In one case a gene analysis showed mutation E200K in prion protein gene, PRNP. Two cases of the Gerstman-Sträussler Scheinker syndrome and one clinical case of fatal insomnia with new PRNP mutation, N181S, were notified. Diagnostic value of protein 14-3-3 analysis in the liquor reached 82% sensitivity and 71% specificity. 25 cases of notified clinically possible/probable CJD were disproved after autopsy. In eleven notified possible CJD cases the autopsy had not been performed. Variant CJD has not yet been proven in Slovenia.
Incidence rates were comparable with other European countries. Completeness of reporting and proper management of CJD cases according to the algorithm of reporting, management and case confirmation would need some improvement. A well-functioning surveillance system, including timely notifications, would enable an appropriate epidemiological investigation and an effective response to public health risks, thus the awareness of prion diseases should not decline.
Kritik in der Krise Flügel-Martinsen, Oliver; Mohammed, Samia; Vasilache, Andreas ...
2020
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Odprti dostop
Kritisches Denken auch in Krisensituationen nicht aufzugeben – dies hat sich der vorliegende Band zur kritischen politischen Theorie in der Corona-Pandemie zur Aufgabe gemacht. Entstanden sind 13 ...Beiträge, die vielfältige Perspektiven auf die Verschränkung von Kritik und Krise bieten. Dabei stellt sich zum einen die Frage, welche Konsequenzen sich für kritisches politisches Denken aus der gegenwärtigen Krise ergeben. Zum anderen ist zu diskutieren, welchen Beitrag kritische Theorie zum Verständnis der aktuellen Herausforderungen leisten kann. Mit Beiträgen von Clara Arnold, Simon Duncker, Oliver Flügel-Martinsen, Lea Jonas, Kristoffer Klement, Jamila Maldous, Noah Marschner, Samia Mohammed, Malte Pasler, Demokrat Ramadani, Gerrit Tiefenthal, Andreas Vasilache und Nele Weiher. In times of crises, critical thinking needs to be maintained and fostered. This volume on critical political theory in the coronavirus pandemic brings together 13 contributions that offer a variety of perspectives on the interrelationship between critique and crisis. What are the consequences of the current crisis for critical political thinking—and what contribution can critical theory offer to our understanding of current challenges? With contributions by Clara Arnold, Simon Duncker, Oliver Flügel-Martinsen, Lea Jonas, Kristoffer Klement, Jamila Maldous, Noah Marschner, Samia Mohammed, Malte Pasler, Demokrat Ramadani, Gerrit Tiefenthal, Andreas Vasilache and Nele Weiher.
Lehren aus Corona Hollstein, Bettina; Neuhäuser, Christian; Brink, Alexander ...
2020
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Odprti dostop
Zusammenfassung Krisen wie die COVID-19-Pandemie sind für die Politik stets Anlass gewesen, festgefahrene Strukturen aufzubrechen und weitreichende Reformen umzusetzen. Pfadabhängigkeiten können in ...Krisenzeiten unterbrochen werden. Der vorliegende Band beleuchtet die gesellschaftlichen Auswirkungen der Pandemie sowie die langfristigen Herausforderungen und Potenziale, die mit ihr einhergehen, aus wirtschafts- und unternehmensethischer Perspektive. Wie verändert die COVID-19-Krise das Kräfteverhältnis zwischen Staat, Markt und Unternehmen? Welche Pflichten kommen auf Unternehmen während einer Pandemie zu? Inwieweit sind die Bekämpfung der Corona- und der Klima-Krise vereinbar? Welche Rolle kann und soll Wirtschaftsethik in Zeiten der Krise spielen? Mit Beiträgen von Prof. Dr. Michael S. Aßländer; Prof. Dr. Jörg Althammer; Prof. Dr. Martin Büscher; Niklas Dummer, M.A.; Dr. habil. Michael Ehret; Miriam Fink; Prof. Dr. Manfred Fischedick; Prof. Dr. Nils Goldschmidt; Prof. Dr. Hanns-Stephan Haas; PD Dr. Michaela Haase; Prof. Dr. Ludger Heidbrink; Prof. Dr. Ulrich Hemel; Prof. Dr. Lars Hochmann; Ruzana Liburkina, M.A.; Mark McAdam; Prof. em. Dietmar Mieth; Prof. Dr. Dr. Elmar Nass; Dr. Laura Otto; Prof. Dr. Reinhard Pfriem; Prof. Dr. Ingo Pies; Prof. em. Birger Priddat; Frauke Remmers; Dr. Bastian Ronge; Prof. Dr. Hartmut Rosa; Prof. em. Hermann Sautter; Dr. Philipp Schepelmann; Prof. Dr. Dr. Ulrich Schmidt; Prof. Dr. Markus Scholz; Prof. Dr. Andreas Suchanek; Prof. em. Peter Ulrich. Abstract Historically, crises such as the COVID-19 pandemic have prompted politicians to break up dead-locked structures and implement far-reaching reforms. Path dependencies can be interrupted in times of crisis. This volume examines the social impact of the current pandemic as well as both the long-term challenges it poses and the potential it offers from the perspective of economic and business ethics. How has the COVID-19 crisis changed the balance of power between the state, markets and business? What are the obligations of companies during a pandemic? To what extent are the fight against the coronavirus crisis and that against the climate crisis compatible? What role can and should business ethics play in times of crisis? With contributions by Prof. Dr. Michael S. Aßländer; Prof. Dr. Jörg Althammer; Prof. Dr. Martin Büscher; Niklas Dummer, M.A.; Dr. habil. Michael Ehret; Miriam Fink; Prof. Dr. Manfred Fischedick; Prof. Dr. Nils Goldschmidt; Prof. Dr. Hanns-Stephan Haas; PD Dr. Michaela Haase; Prof. Dr. Ludger Heidbrink; Prof. Dr. Ulrich Hemel; Prof. Dr. Lars Hochmann; Ruzana Liburkina, M.A.; Mark McAdam; Prof. em. Dietmar Mieth; Prof. Dr. Dr. Elmar Nass; Dr. Laura Otto; Prof. Dr. Reinhard Pfriem; Prof. Dr. Ingo Pies; Prof. em. Birger Priddat; Frauke Remmers; Dr. Bastian Ronge; Prof. Dr. Hartmut Rosa; Prof. em. Hermann Sautter; Dr. Philipp Schepelmann; Prof. Dr. Dr. Ulrich Schmidt; Prof. Dr. Markus Scholz; Prof. Dr. Andreas Suchanek; Prof. em. Peter Ulrich
Pediatrična endokrinologija je začela s svojim neodvisnim razvojem zgodaj v splošnem razvoju te specilanosti, z izrazitim poudarkom na raziskovalnemu delu in klinični odličnosti. Slovenska ...pediatrična endokrinologija je bila že od začetkov evropske pediatrične endokrinologije njen sestavni del, še posebej kot soustanoviteljica prve mednarodne skupine ‘International Study Group for Diabetes in Children and Adolescents’. Po pionirskem delu prof. dr. Leva Matajca je prof. dr. Ciril Kržišnik KO za endokrinologijo, diabetes in bolezni presnove Pediatrične klinike v Ljubljani trdno vpel v mednarodno znanstveno skupnost. V zadnjem desetletju KO sodeluje pri vrhunskem raziskovalnem delu in zagotavlja klinično oskrbo po najvišjih mednarodnih standardih.
Objectives. In Slovenia, the role of family physicians in primary care and preventive procedures is very important. Influenza vaccination rates in Slovenia are low. The reasons for low vaccination ...rates in Slovenia were not clear. We suppose that patient’s beliefs and attitudes are important factors. We assessed patients’ opinions regarding the acceptance of flu vaccination by their family physicians and their beliefs and attitudes about flu and vaccination. The aim was to check out factors that influence the decision to take the vaccine in family physician offices.
Methods. This was a cross-sectional, multicenter, observational study in the Styria region in Slovenia. We included patients from seven family physicians during regular office visits. They filled in a questionnaire about their general demographic data and attitudes regarding influenza and vaccination. The main outcome was the decision to be vaccinated.
Results. The logistic regression model identified five predictors for influenza vaccination, namely: heart disease, previous vaccination, an agreement with the beliefs ‘the vaccination is an efficient measure to prevent influenza’, ‘after the vaccination there are usually no important side effects’ and ‘the vaccination is also recommended for a healthy adult person’. The belief that vaccinations harm the immune system is negatively associated with vaccination.
Conclusions. Patients’ beliefs are an important factor to decide for vaccination or not. Family physician teams should discuss with patients their beliefs and concerns about vaccination.
Uvod. V Sloveniji ima zdravnik družinske medicine pomembno vlogo pri izvajanju preventive. Delež cepljenih proti gripi je v Sloveniji nizek. Razlogi za to niso povsem jasni. Preučevali smo mnenje bolnikov glede cepljenja proti gripi pri njihovem družinskem zdravniku ter njihova stališča in prepričanja o gripi in cepljenju. Cilj naloge je bil odkriti dejavnike, ki vplivajo na odločitev o cepljenju v ambulanti družinske medicine.
Metode. Raziskava je bila presečna multicentrična opazovalna. Vključili smo bolnike iz 7 ambulant družinske medicine na Štajerskem v Sloveniji. Vzorec je zajemal bolnike, ki so prišli v ambulanto. Izpolnili so vprašalnik z demografskimi podatki ter stališči o gripi in cepljenju. Glavni opazovani dogodek je bil odločitev za cepljenje.
Rezultati. V logističnem regresijskem modelu so bili najpomembnejši napovedni dejavniki odločitve za cepljenje srčna bolezen, cepljenje v preteklosti, strinjanje, da je cepljenje najbolj učinkovit ukrep proti gripi, strinjanje, da cepljenje običajno nima pomembnih stranskih učinkov, in strinjanje, da je cepljenje priporočljivo tudi za odraslo zdravo osebo. Prepričanje, da cepljenje škodi imunskemu sistemu, je negativni napovedni dejavnik odločitve za cepljenje.
Zaključki. Stališča bolnikov so pomemben dejavnik pri odločitvi za cepljenje. V ambulantah družinske medicine bi se morali z bolniki več pogovarjati o njihovih stališčih in pomislekih o cepljenju.
Izhodišča: Samoocena zdravja predstavlja bolnikov občutek lastnega zdravja; vključuje biološke, sociološke in psihološke dejavnike. Pogosto se uporablja v populacijskih raziskavah, osebni zdravnik pa ...lahko z njeno pomočjo pridobi dodatne informacije o bolniku in njegovih potrebah.
A fungicide is a chemical pesticide compound that kills or inhibits the growth of fungi. In agriculture, fungicide is used to control fungi that threaten to destroy or compromise crops. Fungicides ...for Plant and Animal Diseases is a book that has been written to present the most significant advances in disciplines related to fungicides. This book comprises of 14 chapters considering the application of fungicides in the control and management of fungal diseases, which will be very helpful to the undergraduate and postgraduate students, researchers, teachers of microbiology, biotechnology, agriculture and horticulture.
Paediatric endocrinology started its independent development early in the general development of this specialty, with a strong focus on research and clinical excellence. Slovenian paediatric ...endocrinology was an integral part of the European paediatric endocrinology from its beginnings and a founding member of the first ‘International Study Group for Diabetes in Children and Adolescents’. After the pioneering work of Prof. Lev Matajc, Prof. Ciril Kržišnik firmly integrated the Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases at the University Children’s Hospital in Ljubljana in the international scientific community. In the last decade, the department participates in cutting-edge research and provides clinical services at highest international standards.
Pediatrična endokrinologija je začela s svojim neodvisnim razvojem zgodaj v splošnem razvoju te specilanosti, z izrazitim poudarkom na raziskovalnemu delu in klinični odličnosti. Slovenska pediatrična endokrinologija je bila že od začetkov evropske pediatrične endokrinologije njen sestavni del, še posebej kot soustanoviteljica prve mednarodne skupine ‘International Study Group for Diabetes in Children and Adolescents’. Po pionirskem delu prof. dr. Leva Matajca je prof. dr. Ciril Kržišnik KO za endokrinologijo, diabetes in bolezni presnove Pediatrične klinike v Ljubljani trdno vpel v mednarodno znanstveno skupnost. V zadnjem desetletju KO sodeluje pri vrhunskem raziskovalnem delu in zagotavlja klinično oskrbo po najvišjih mednarodnih standardih.
Objectives. Health-related quality of life (HRQoL) measures a patient’s subjective experience of his or her health status. We aimed to show how the presence of chronic diseases and satisfaction with ...family physicians (FPs) were associated with the HRQoL of a Roma population.
Methods. A cross-sectional study was carried out in May 2011 on a representative sample of 650 Roma living in Prekmurje, Slovenia. The EQ-5D questionnaire was used for measuring the HRQoL of the Roma. Demographical data, 12 groups of diseases diagnosed in the last 12 months and satisfaction with FPs were included in the questionnaire.
Results. The response rate was 88.3% (574), of which 56.4% were female, and the average age of the participants had a mean value of 40.2±12.7 years. The presence of cardiovascular problems with risk factors for them or presence of musculoskeletal disorders were strongly associated with the presence of pain (Cramer’s V = 0.40 and 0.46 respectively).There was a strong association between the presence of mental disorders and anxiety and depression (Cramer´s V = 0.58). The average satisfaction with the family physician was 3.9 (mean±1.10) on a five-point Likert scale. There was no significant association between HRQoL and satisfaction with the family physician.
Conclusions. Roma with chronic mental health problems had the lowest HRQoL in the Roma population. More attention should be paid to this subgroup of Roma in family medicine, and interventions should be provided. High satisfaction with their FPs is not associated with the observed quality of life variables
Uvod. Z zdravjem povezana kakovost življenja (HRQoL) je odraz pacientove subjektivne ocene lastnega zdravstvenega stanja. V naši raziskavi smo skušali ugotoviti, kakšen je vpliv nekaterih kroničnih bolezni in zadovoljstva z izbranim zdravnikom na HRQoL med romskim prebivalstvom.
Metode. Maja 2011 smo izvedli presečno raziskavo v reprezentativnem vzorcu 650 pomurskih Romov. HRQoL smo merili z vprašalnikom EQ-5D; vključili smo še demografske podatke, zadovoljstvo z izbranim družinskim zdravnikom in 12 bolezenskih stanj, ki so bila diagnosticirana v zadnjih 12 mesecih.
Rezultati. Odzivnost je bila 88,3-odstotna (574), 56,4 % je bilo žensk in povprečna starost sodelujočih je bila 40,2 +/- 12,7 leta. Nizek HRQoL v skupini s srčno-žilnimi boleznimi z dejavniki tveganja zanje in kostnomišičnimi boleznimi je bil močno povezan s prisotnostjo bolečine (Cramer z V = 0,40 in 0,46). V skupini z duševnimi težavami pa je bila močna povezava nizkega HRQoL s prisotnimi znaki anksioznosti in depresije (Cramer z V = 0,58). Povprečno zadovoljstvo z zdravnikom družinske medicine je bilo 3,9 (mediana +/- 1,10) na pettočkovni Likertovi lestvici. Ni bilo statistične povezave med HRQoL in zadovoljstvom z zdravnikom družinske medicine.
Zaključki. Romi s prisotnostjo duševnih težav imajo najnižji HRQoL v romskem prebivalstvu. Več pozornosti bi v družinski medicini morali posvetiti tej podskupini Romov. Zadovoljstvo z zdravnikom družinske medicine ni povezano z opazovanimi spremenljivkami kakovosti življenja
Introduction. In May of 2012, we investigated a food-borne Clostridium perfringens outbreak in Slovenia involving a single kitchen and five venues, with 477 exposed persons.
Methods. In order to ...identify the causative agent, vehicle of infection and source of contamination, we conducted microbiological and environmental investigations and an analytical cohort study (n = 138).
Results. The case definition in the outbreak was met by 104 persons. Predominant symptoms were diarrhoea, nausea and abdominal cramps. Median incubation time and duration of illness were 12 and 22.5 hours respectively. Stool samples were collected from 18 persons and in 13 C. perfringens spores were present; enterotoxin was detected in 9 persons. PCR and PFGE analysis of isolates from a cook with earlier onset time, who did not consume the implicated food, and cases from four venues showed the same strain of C. perfringens type A (with cpe-gene), indistinguishable by PFGE analysis. No food samples could be obtained. An analytical study showed that one food item (French salad) was the most likely vehicle of infection (RR: 6.35; 95% CI: 1.62-24.90).
Conclusions. This was the largest C. perfringens outbreak in Slovenia to date. Proper analytical study in combination with detailed laboratory investigation with genotypisation enabled us to identify a causative agent, vehicle of infection and possible source of contamination. Fast response and interdisciplinary collaboration led to timely implementation of control measures. These have led to the kitchen acquiring new equipment and improving staff knowledge of risks and processes, thus reducing the likelihood of future reoccurrences
Uvod. V maju 2012 smo preiskovali izbruh okužb s Clostridium perfringens, prenesenih s hrano, v katerega so bile vpletene ena kuhinja in pet lokaciji s 477 izpostavljenimi osebami.
Metode. Da bi ugotovili povzročitelja, pot prenosa in vir kontaminacije, smo izvedli laboratorijsko in okoljsko preiskavo ter analitično kohortno raziskavo (n = 138).
Rezultati. Definiciji primera v izbruhu so ustrezale 104 osebe. Prevladujoči simptomi so bili: driska, slabost in trebušni krči. Mediana časa inkubacije in trajanja bolezni je bila 12 ur in 22,5 ure. Vzorci blata so bili odvzeti 18 osebam; pri 13 so bile prisotne spore C. perfringens, enterotoksin je bil zaznan pri 9 osebah. PCR- in PFGE-analiza izolatov kuharja z zgodnejšim časom pojava obolenja, ki ni užival impliciranih živil, in primerov s štirih lokacij sta pokazali enak sev C. perfringens tipa A (s cpe genom), ki se ni razlikoval pri analizi PFGE. Vzorcev živil ni bilo mogoče pridobiti. Analitična študija je pokazala, da je bila najverjetnejša pot prenosa okužbe eno izmed živil (francoska solata) (RT: 6,35; 95% IZ: 1,62-24,90).
Zaključek. To je bil največji izbruh s C. perfringens v Sloveniji do zdaj. Ustrezna analitična raziskava v kombinaciji s podrobno laboratorijsko preiskavo z genotipizacijo nam je omogočila identifikacijo povzročitelja, pot prenosa okužbe in mogoč vir kontaminacije. Hiter odziv in interdisciplinarno sodelovanje je pripeljalo do pravočasne implementacije nadzornih ukrepov. Ti so privedli do nabave nove opreme v kuhinji, izboljšanja znanja osebja o tveganjih in procesih ter s tem zmanjšali verjetnost za ponovitve v prihodnje
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