Shortly after Pearl Harbor, the Japanese Imperial Army invaded the Dutch East Indies, now known as Indonesia. A deceitful campaign promoting Asian brotherhood recruited and coerced young Indonesian ...men to support the Japanese occupation with the sinister outcome that several million of them were worked to death or summarily killed as expendable slave laborers, orromusha, as they were called.
While many romusha disappeared from the record, nine hundred were known victims of a brutal and immoral medical experiment perpetuated by an increasingly desperate Imperial Japan. In anticipation of a land assault, the Japanese needed a means to protect their troops from tetanus, and they used these nine hundred men as human guinea pigs to test an insufficiently vetted vaccine. Within days, all nine hundred suffered the protracted, agonizing death of acute tetanus.
With the Allied forces poised for victory, the Japanese needed a scapegoat for this well-documented incident if they were to avoid war-crimes prosecution. They brutally tortured Achmad Mochtar, a native Indonesian and renowned scientist, along with his colleagues at the Eijkman Institute in Batavia (now Jakarta), until Mochtar signed a confession to the murders in exchange for the liberty of his fellow scientists. The Japanese beheaded Mochtar weeks before the war ended.War Crimes in Japan-Occupied Indonesiaunravels the deceit of the Japanese Army, the reasons for the mass murder of the romusha, and Mochtar's heroic role in these tragic events. The end result finds justice for Mochtar and reveals the true extent of one of the least recognized war crimes of World War II.
The timely arrival of novel materials plays a key role in bringing advances to society, as the pace at which major technological breakthroughs take place is usually dictated by the discovery rate at ...which novel materials are identified within chemical space. High‐throughput experimentation and computation strategy, now widely considered as a watershed in accelerating the discovery and optimization of novel materials in virtually every field, enables simultaneous screening, synthesis and characterization of large arrays of different material classes toward identification of the lead candidates for given system and targeted application. However, the ability to acquire data, through the continued advancement of automation platforms and workflows especially in the field of battery research and development, often outpaces the ability to optimally leverage obtained data for improved decision‐making. Closing this gap inevitably calls for adapted algorithms, development of reliable predictive models and enhanced integration with machine learning, deep learning, and artificial intelligence. This Review aims to highlight state‐of‐the‐art achievements along with an assessment of current and future challenges as well as resulting perspectives toward accelerated development of advanced battery electrolytes and their interfaces.
Accelerated discovery and development of novel battery materials, especially electrolytes and their interfaces within battery chemistries of interest, unquestionably call for complementary and synergistic high‐throughput experimentation (HTE) and a high‐throughput virtual screening approach. Well‐designed HTE workflows result in a wealth of experimental datasets as a solid foundation for enhanced technical decision making based on adapted machine learning‐based algorithms and high‐performance computing tools.
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing ...medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer. This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal ...research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the “ARRIVE Essential 10,” which constitutes the minimum requirement, and the “Recommended Set,” which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration (E&E) document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
The Design and Conduct of Meaningful Experiments Involving Human Participants combines an introduction to scientific culture and ethical mores with specific experimental design and procedural ...content. Author R. Barker Bausell assumes no statistical background on the part of the reader, resulting in a highly accessible text.
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