In order to identify the chemical constituents of vegetal material it is important that an efficient extraction procedure is followed which provides both an efficient extraction and also limits the ...decomposition of extracted compounds during the process. Traditional methods such as distillation, solvent extraction and cold compression continue to be used but significant improvements can be achieved with the application of either ultrasound or microwave technologies. In this review we will discuss the development of these methods and review the advantages which can be achieved.
•The review highlights improvements to solvent extraction assisted by ultrasound or microwave energy.•Possible mechanisms of UAE and MAE are discussed.•Optimisation and best practise are considered.•The potential for development of these methods for industry are considered
This paper presents a community effort to develop good practice guidelines for the validation of global coarse-scale satellite soil moisture products. We provide theoretical background, a review of ...state-of-the-art methodologies for estimating errors in soil moisture data sets, practical recommendations on data pre-processing and presentation of statistical results, and a recommended validation protocol that is supplemented with an example validation exercise focused on microwave-based surface soil moisture products. We conclude by identifying research gaps that should be addressed in the near future.
•Satellite soil moisture validation methods are reviewed•Community-agreed validation good practice guidelines are presented•A standardized satellite soil moisture validation protocol is provided
Sustainable natural resource use and management make novel demands on governance arrangements, the design of which requires normative guidance. Although governance principles have been developed for ...diverse contexts, their availability for sustainable natural resource governance is so far limited. In response, we present a suite of governance principles for natural resource governance that, while developed in an Australian multilevel context, has general applicability and significance at local, subnational, and national scales. The principles can be used to direct the design of governance institutions that are legitimate, transparent, accountable, inclusive, and fair and that also exhibit functional and structural integration, capability, and adaptability. Together, they can also serve as a platform for developing governance monitoring and evaluation instruments, crucial for both self-assessment and external audit purposes.
Clinical and public health guidelines include a variety of types of normative statements concerning interventions. “Recommendations” are usually the central focus, and are based on one or more ...systematic reviews of research evidence. Guidelines may include other types of normative statements, however, including Grading of Recommendations, Assessment, Develoment, and Evaluation (GRADE) good (or best) practice statements (GPS), which represent recommendations that guideline panels feel are important but are not appropriate for formal ratings of quality of evidence because it is sufficiently obvious that desirable effects outweigh undesirable effects. These normative statements are typically supported by a great deal of high-certainty, indirect evidence, which the authors feel would be a waste of time to examine. There are a number of conceptual and methodological issues with GRADE GPS, however, and these are manifested in guidelines, including both inappropriate overuse and underuse, and unclear interpretation and impact among end-users. This situation has arisen in part from lack of clarity in, and misunderstandings of, GRADE guidance, the lumping of many different types of normative statements under one label (“GPS”), from limitations in GRADE's approach to linked bodies of evidence, and because the appropriate basis for many normative statements about interventions is not reviews of research evidence. A new typology is needed for normative statements on interventions and policies that are not optimally based on reviews of research evidence.
This proposed typology differentiates normative statements about interventions by the type or nature of the most appropriate basis for the statement. The typology encompasses the range of statements encompassed by GPS, but provides a more nuanced categorization designed to assist both guideline developers and end-users. This typology encompasses two main types of normative statements about interventions (including policies): (1) statements that indicate when to use (or not) an intervention, which intervention to use, and if, when and how to use it and (2) the principles, practices, or norms that inform or underpin such interventions. These correspond to normative statements based on empirical evidence, and those based on human rights, ethics, or norms, respectively. Normative statements based on empirical evidence include: (1) recommendations based on systematic reviews of human or animal evidence on effectiveness and harms, including linked bodies of evidence; (2) normative statements based on scientific fundamentals (eg, physical/biological/chemical properties, theories, laws, or principles); and (3) implementation guidance based most commonly on experiential evidence such as case studies. Normative statements based on human rights, ethics, or norms include: (1) guiding principles, based on human rights standards and conventions and/or ethics principles; and (2) practice norms and standards, based on clinical and public health norms and/or professional standards.
There are conceptual and methodological problems with GRADE GPS, leading to their misapplication, with overuse and underuse. This paper presents a proposal for a new typology for normative statements on interventions, according to the basis for the statement. This typology encompasses and replaces GPS, providing a more nuanced set of statements. Testing of this proposed approach is needed among both guideline developers and end-users.
Modern trends in the tourism market, especially at a time when the world is affected by an epidemic of global proportions, has conditioned the return to nature, healthy lifestyles, domestic products ...and the need for psychophysical rest. More and more tourists are opting for shorter trips and stays in rural areas, away from the crowds that are present in popular tourist destinations. The Russian Federation is an area with significant resources for the development of rural tourism. Today, a number of Russian regions, relying on the unique nature, rich cultural and material heritage, traditions of the rural population are successfully implementing projects in the field of rural tourism. Such regions include the Kaluga, Vologda and Yaroslavl regions, the Altai Republic, Buryatia and Khakassia, and many others. According to the latest research, the potential of rural tourism in Russia in the next 10-15 years can be estimated at 50 billion rubles. The aim of this paper is to point out the possibilities of improving and developing rural tourism in the region based on this example of good practice.
Closing the emissions gap between Nationally Determined Contributions (NDCs) and the global emissions levels needed to achieve the Paris Agreement's climate goals will require a comprehensive package ...of policy measures. National and sectoral policies can help fill the gap, but success stories in one country cannot be automatically replicated in other countries. They need to be adapted to the local context. Here, we develop a new Bridge scenario based on nationally relevant, short-term measures informed by interactions with country experts. These good practice policies are rolled out globally between now and 2030 and combined with carbon pricing thereafter. We implement this scenario with an ensemble of global integrated assessment models. We show that the Bridge scenario closes two-thirds of the emissions gap between NDC and 2 °C scenarios by 2030 and enables a pathway in line with the 2 °C goal when combined with the necessary long-term changes, i.e. more comprehensive pricing measures after 2030. The Bridge scenario leads to a scale-up of renewable energy (reaching 52%-88% of global electricity supply by 2050), electrification of end-uses, efficiency improvements in energy demand sectors, and enhanced afforestation and reforestation. Our analysis suggests that early action via good-practice policies is less costly than a delay in global climate cooperation.
Abstract
STUDY QUESTION
Which add-ons are safe and effective to be used in ART treatment?
SUMMARY ANSWER
Forty-two recommendations were formulated on the use of add-ons in the diagnosis of fertility ...problems, the IVF laboratory and clinical management of IVF treatment.
WHAT IS KNOWN ALREADY
The innovative nature of ART combined with the extremely high motivation of the patients has opened the door to the wide application of what has become known as ‘add-ons’ in reproductive medicine. These supplementary options are available to patients in addition to standard fertility procedures, typically incurring an additional cost. A diverse array of supplementary options is made available, encompassing tests, drugs, equipment, complementary or alternative therapies, laboratory procedures, and surgical interventions. These options share the common aim of stating to enhance pregnancy or live birth rates, mitigate the risk of miscarriage, or expedite the time to achieving pregnancy.
STUDY DESIGN, SIZE, DURATION
ESHRE aimed to develop clinically relevant and evidence-based recommendations focusing on the safety and efficacy of add-ons currently used in fertility procedures in order to improve the quality of care for patients with infertility.
PARTICIPANTS/MATERIALS, SETTING, METHODS
ESHRE appointed a European multidisciplinary working group consisting of practising clinicians, embryologists, and researchers who have demonstrated leadership and expertise in the care and research of infertility. Patient representatives were included in the working group. To ensure that the guidelines are evidence-based, the literature identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, recommendations were based on the professional experience and consensus of the working group. The guidelines are thus based on the best available evidence and expert agreement. Prior to publication, the guidelines were reviewed by 46 independent international reviewers. A total of 272 comments were received and incorporated where relevant.
MAIN RESULTS AND THE ROLE OF CHANCE
The multidisciplinary working group formulated 42 recommendations in three sections; diagnosis and diagnostic tests, laboratory tests and interventions, and clinical management.
LIMITATIONS, REASONS FOR CAUTION
Of the 42 recommendations, none could be based on high-quality evidence and only four could be based on moderate-quality evidence, implicating that 95% of the recommendations are supported only by low-quality randomized controlled trials, observational data, professional experience, or consensus of the development group.
WIDER IMPLICATIONS OF THE FINDINGS
These guidelines offer valuable direction for healthcare professionals who are responsible for the care of patients undergoing ART treatment for infertility. Their purpose is to promote safe and effective ART treatment, enabling patients to make informed decisions based on realistic expectations. The guidelines aim to ensure that patients are fully informed about the various treatment options available to them and the likelihood of any additional treatment or test to improve the chance of achieving a live birth.
STUDY FUNDING/COMPETING INTEREST(S)
All costs relating to the development process were covered from ESHRE funds. There was no external funding of the development process or manuscript production. K.L. reports speakers fees from Merck and was part of a research study by Vitrolife (unpaid). T.E. reports consulting fees from Gynemed, speakers fees from Gynemed and is part of the scientific advisory board of Hamilton Thorne. N.P.P. reports grants from Merck Serono, Ferring Pharmaceutical, Theramex, Gedeon Richter, Organon, Roche, IBSA and Besins Healthcare, speakers fees from Merck Serono, Ferring Pharmaceutical, Theramex, Gedeon Richter, Organon, Roche, IBSA and Besins Healthcare. S.R.H. declares being managing director of Fertility Europe, a not-for-profit organization receiving financial support from ESHRE. I.S. is a scientific advisor for and has stock options from Alife Health, is co-founder of IVFvision LTD (unpaid) and received speakers’ fee from the 2023 ART Young Leader Prestige workshop in China. A.P. reports grants from Gedeon Richter, Ferring Pharmaceuticals and Merck A/S, consulting fees from Preglem, Novo Nordisk, Ferring Pharmaceuticals, Gedeon Richter, Cryos and Merck A/S, speakers fees from Gedeon Richter, Ferring Pharmaceuticals, Merck A/S, Theramex and Organon, travel fees from Gedeon Richter. The other authors disclosed no conflicts of interest.
DISCLAIMER
This Good Practice Recommendations (GPRs) document represents the views of ESHRE, which are the result of consensus between the relevant ESHRE stakeholders and are based on the scientific evidence available at the time of preparation.
ESHRE GPRs should be used for information and educational purposes. They should not be interpreted as setting a standard of care or bedeemedinclusive of all proper methods of care, or be exclusive of other methods of care reasonably directed to obtaining the same results.Theydo not replace the need for application of clinical judgement to each individual presentation, or variations based on locality and facility type.
Furthermore, ESHRE GPRs do not constitute or imply the endorsement, or favouring, of any of the included technologies by ESHRE.
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