Lamotrigine caught marketing approval for combination therapy to refractory epileptics of whom the other antiepileptic drugs were not effective in December, 2008 and for maintenance therapy to the ...bipolar disorder in July, 2011. In our hospital, lamotrigine has been adopted since September, 2009. We investigated for 177 patients (male 51, female 126) who were prescribed lamotrigine from July1st, 2011 to July 31st, 2014. The mean age of the patients was 45.5. Of 177 patients, the number of the bipolar disorder was 96 (bipolarⅠ32, Ⅱ64). The discontinuation of the prescription was 80 cases. The reasons were: ineffective in 28 patients, side effects in 25 and so on, containing rash in 22 patients. Of 97 continuing cases, lamotrigine was estimated as effective in 76 cases. Lamotrigine was found to be effective for depressive state and maintenance therapy of bipolar disorder.
Wir berichten über die erste in der Schweiz eingesetzte Osteo-Odonto-Keratoprothese (OOKP). Die Operation wird bei bilateralem kornealem Visusverlust durchgeführt. Beim zweizeitigen Eingriff wird ein ...Zahn mit umgebenden Knochen entnommen, und ein optischer Zylinder eingesetzt. Dieser Zahn-Knochen-Plexiglaskomplex wird für drei Monate infraorbital in eine Weichteiltasche implantiert. Danach wird der Zahnknochenplexiglaskomplex entnommen und die darunterliegende Hornhaut wird für die Aufnahme der Optik trepaniert, Linse, Iris und der vordere Glaskörper werden entfernt und die Prothese auf den Bulbus fixiert. Unser Patient sieht aktuell bestkorrigiert 0,7.
We report on the first implanted Osteo-Odonto-Keratoprosthesis (OOKP) in Switzerland. The procedure is only performed in cases of severe bilateral corneal vision impairment without alternatives (e. g. allogenic corneal transplant). At this two-staged surgery a single-rooted tooth is removed with its belonging bone and an optic cylinder is centrally inserted. This tooth-bone-optic-cylinder-complex is implanted temporarily submuscular in the infraorbital area. Oral mucosa is removed and transplanted on to the eye. Three months later the complex is removed, the oral mucosa partially detached, the underlying cornea perforated, the lens, iris and anterior vitreous body removed and the tooth-optic-zylinder-complex fixated on the globe. After this procedure, our patient has a best corrected visual acuity of 0,7.
UN CAZ DE SINDROM STEVENS JOHNSON LA COPIL Cristina Oana Mărginean; Maria Despina Baghiu; Carmen Duicu ...
Revista română de pediatrie,
06/2012, Letnik:
61, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Prezentăm cazul unui băiat de 9 ani cu epilepsie refractară la tratamentul anterior, diagnosticat cu sindrom Stevens Johnson apărut după introducerea în tratament a Lamictalului. Băiatul a prezentat ...febră, exantem polimorf maculo-papulo-eritematos, cu elemente veziculo buloase generalizate şi denudare tegumentară, conjunctivită, leziuni bucale. Pneumonia asociata am interpretat-o ca afectare a mucoasei tractului respirator inferior din cadrul sindromului Stevens Johnson. Evoluţia bolii a fost favorabilă după doze mari de imunoglobuline intravenos. În concluzie, deşi incidenţa sindromului Steven Johnson este mică la copil, pediatrii trebuie să fi e conştienţi de posibilitatea apariţiei ei (chiar după antiepileptice – Lamictal), iar utilizarea imunoglobulinelor IV, deşi con troversată, administrată în doze mari pare că duce la vindecarea bolii.
Background: Poisoning is one of the medical emergencies. Poisoning with new Anticonvulsant drugs such as lamotrigine, sodium valproate, topiramate and gabapentin has been observed alone or in ...combination with other drugs in the last few years. Therefore this study was performed regarding the poisoning with new anticonvulsant drugs with respect to demographic, clinical manifestations, length of hospital stay, outcome and correlation between the outcome and different variables. Methods: This study was a descriptive-analytical and cross-sectional study. Simple sampling method was performed in the Noor and AliAsghar Hospital on poisoning cases with new anticonvulsant drugs. Need to intubation, connected to ventilator and aspiration pneumonia were considered as outcome Statisticial analysis was done by SPSS17 using ANOVA, Student t-test and logistic regression. Findings: Poisoning with Sodium valproate was more common than Lamotrigine, Topiramate and Gabapentin. The Mean (SD) age of study population was 27.67 (9.74) years old. The most important prediciting factors in outcome incidence were sex (male), seizure, cardiovascular and respiratory symptoms in poisoning with Sodium valproate and seizure in poisoning with Lamotrigine. One death occurred in poisoning with Sodium valproate. Conclusion: Average age of patient was about 27.67 years which may be due to the use of these drugs in the younger age groups. The higher length of hospital stay in patients with respiratory symptoms in Sodium valproate and Lamotrigine poisoning would be because of more complications (intubation, ventilation and aspiration penumonia) observed with these two drugs.
Analgesic activity of a new anticonvulsive agent lamotrigin was studied on the model of neurogenic pain syndrome produced in rats by penicillin applied to the dorsal surface of the spinal cord and by ...dissection of the sciatic nerve. Lamotrigin was shown to have a profound analgesic activity. It can be used as an efficient prophylactic agent for prevention of chronic pain syndromes by suppression of the generators of pathologically enhanced excitation in the nociceptive structures which are the pathophysiological basis of the chronic pain syndromes.PUBLICATION ABSTRACT
Reakcija na lijek s eozinofilijom i sistemskim simptomima (DRESS, engl. Drug Reaction with Eosinophilia and Systemic
Symptoms), ili sindrom preosjetljvosti uzrokovan lijekom (DIH S, engl.Drug-inducec ...Hypersensitivity Syndrome), je
često neprepoznato i potencijalno životno ugrožavajuća reakcija preosjetljivosti povezana s uzimanjem raznih lijekova, najčešće
antiepilepticima. Pacijenti s DRESS/DIH S se najčešće prezentiraju osipom, febrilitetom i zahvaćanjem unutarnjih
organa. U ovom prikazu slučaja predstavljena je pacijentica koja je nakon uzimanja lamotrigina razvila osip, visoki febrilitet,
edem lica te hepatitis. Po primitku u bolnicu, isključena je sva dotadašnja terapija te započeto sistemsko liječene kortikosteroidima.
Ovaj rad sugerira razmatranje dijagnoze DRESS/DIH kod pacijenata s naglom pojavom osipa te sistemskim simptomima,
a nakon uvođenja novog lijeka u terapiju te se preporuča agresivniji pristup u terapiji osim prestanka uzimanja
uzročnog lijeka. Rano prepoznavanje može smanjiti rizik komplikacija i mortalitet.
Two studies in healthy male volunteers were carried out to evaluate the pharmacokinetic profile of a new divisible formulation of lamotrigine (CAS 84057-84-1, Plexxo, Lamotrigin Desitin) in plasma in ...comparison to plain or dispersible lamotrigine tablets.
The plasma pharmacokinetics of lamotrigine were analysed after administration of single doses of 100 mg lamotrigine given as one tablet of the new formulation and either the plain or the dispersible reference formulation in two separate studies. In each study the data of 24 subjects were analysed according to the study protocol. Venous blood samples were taken at appropriate intervals up to 120 h after dosing. Concentrations of lamotrigine were determined in plasma by a validated HPLC method using UV detection.
In both studies, mean plasma concentration-time profiles of the new lamotrigine formulation and both reference formulations ran nearly in parallel. The pharmacokinetic mean data calculated from different subject groups of the two studies were very similar. The mean ratios of the main pharmacokinetic parameters and the corresponding 90% confidence intervals of AUC(0-t), AUC(0-inf) and C(max) were 103% (99.7-105.7), 103% (99.6-107.3) and 101% (95.2-106.6) for the comparison with the plain lamotrigine tablet and 100% (98.0-102.8), 100% (96.5-102.8) and 102% (99.1-105.3) for the comparison with the dispersible/chewable tablet, respectively. The most frequently reported adverse events possibly related to the administration of lamotrigine were headache and dizziness in both studies. It is concluded that the new divisible lamotrigine formulation is bioequivalent with regard to rate and extent of absorption to both the plain reference lamotrigine product and to the dispersible/chewable reference product.
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