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22.
  • SETD5-Coordinated Chromatin... SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
    Wang, Zhentian; Hausmann, Simone; Lyu, Ruitu ... Cancer cell, 06/2020, Letnik: 37, Številka: 6
    Journal Article
    Recenzirano
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    Molecular mechanisms underlying adaptive targeted therapy resistance in pancreatic ductal adenocarcinoma (PDAC) are poorly understood. Here, we identify SETD5 as a major driver of PDAC resistance to ...
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23.
  • More on induced maps on n-f... More on induced maps on n-fold symmetric product suspensions
    Barragán, Franco; Macías, Sergio; Tenorio, Jesús F. Glasnik matematički, 01/2015, Letnik: 50, Številka: 2
    Journal Article, Paper
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    We continue the work initiated by the first named author in Induced maps on n-fold symmetric product suspensions, Topology Appl. 158 (2011), 1192-1205. We consider classes of maps not included in the ...
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24.
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  • Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
    Morris, Erick J; Jha, Sharda; Restaino, Clifford R ... Cancer discovery 3, Številka: 7
    Journal Article
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    The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway. Selective BRAF and MAP-ERK kinase (MEK) ...
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26.
  • The Hippo effector YAP prom... The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
    Lin, Luping; Sabnis, Amit J; Chan, Elton ... Nature genetics, 03/2015, Letnik: 47, Številka: 3
    Journal Article
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    Resistance to RAF- and MEK-targeted therapy is a major clinical challenge. RAF and MEK inhibitors are initially but only transiently effective in some but not all patients with BRAF gene mutation and ...
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27.
  • Biochemical identification of the OsMKK6-OsMPK3 signalling pathway for chilling stress tolerance in rice
    Xie, Guosheng; Kato, Hideki; Imai, Ryozo Biochemical journal, 2012-Apr-01, Letnik: 443, Številka: 1
    Journal Article
    Recenzirano

    MAPK (mitogen-activated protein kinase) pathways have been implicated in stress signalling in plants. In the present study, we performed yeast two-hybrid screening to identify partner MAPKs for OsMKK ...
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28.
  • MAP3K1 and MAP2K4 mutations... MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
    Xue, Zheng; Vis, Daniel J; Bruna, Alejandra ... Cell research, 07/2018, Letnik: 28, Številka: 7
    Journal Article
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    Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show ...
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29.
  • A new image encryption sche... A new image encryption scheme based on hybrid chaotic maps
    Pourjabbar Kari, Ahmad; Habibizad Navin, Ahmad; Bidgoli, Amir Massoud ... Multimedia tools and applications, 2021/1, Letnik: 80, Številka: 2
    Journal Article
    Recenzirano

    In this paper, a novel grayscale image cryptosystem based on hybrid chaotic maps is proposed. The scheme employs both confusion phase to scramble the location of pixels and diffusion phase for ...
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  • The MEKK1-MKK1/MKK2-MPK4 Ki... The MEKK1-MKK1/MKK2-MPK4 Kinase Cascade Negatively Regulates Immunity Mediated by a Mitogen-Activated Protein Kinase Kinase Kinase in Arabidopsis
    Kong, Qing; Qu, Na; Gao, Minghui ... The Plant cell, 05/2012, Letnik: 24, Številka: 5
    Journal Article
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    In Arabidopsis thaliana, the MEKK1-MKK1/MKK2-MPK4 mitogen-activated protein (MAP) kinase cascade represses cell death and immune responses. In mekk1, mkk1 mkk2, and mpk4 mutants, programmed cell ...
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