Humans are not the only species that cares about inequality; individuals in some other species also respond negatively when a social partner receives a better outcome than they do and there is ...(limited) evidence of apes even responding when they receive more than their partner. The distribution of this reaction across species and individual’s responses in experimental cooperation tasks suggests that the response to inequity evolved in the context of cooperation, potentially to help individuals recognize – and thereby avoid – partners who take more than their share. Even though this might cost individuals an absolute gain in the short term, they ultimately benefit by not being relatively disadvantaged. Thus, while clearly there are cultural influences on humans’ responses to inequity, the basic response is biologically rooted, and comparative work will help us better understand why and in what contexts the responses evolved so that we can better understand how our moral and legal systems evolved in the way in which they did and thereby work to design institutions and outcomes that better benefit everyone.
Oscar Robert Boucaut
Persona Studies,
12/2021, Letnik:
7, Številka:
1
Journal Article
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This article applies a persona studies approach to the case study of the Academy Awards. Key literature is used to situate an ‘Oscar’ persona within existing conceptualisations from the discipline. ...Oscar represents a composite persona that encapsulates an event, its broadcast, an Academy of individuals, and a larger discursive industry. It is a non-human persona that is coloured by distinctly human elements; it is collectively constructed on a massive scale, the process of which inviting constant contestation. Drawing from these theorisations I conduct a textual analysis to reach a persona reading of Oscar. As collective authors of the persona, members of the Academy, associated performers, and discursive contributors employ three distinct and consistent persona strategies: the Functional, the Spiritual, and the Ironic. Oscar’s taste-making function is enabled by extravagant staging and tempered by expressions of philanthropy yet performed with ironic self-effacement. The cumulative effect of these three performances allows Oscar manoeuvrability across the requirements of the different cultural contexts of each year. As well as providing a unique prism for understanding the Oscars as an institution, this work demarcates different levels of collective persona construction, challenging notions of central authority in production and performance, and accounting for the ongoing constructive work of publics.
The Mars Exploration Rover Opportunity operated on Mars from 2004 until it was disabled by a dust storm in 2018. Its demise was declared in February 2019 after months of unsuccessful recontact ...attempts by scientists at the National Aeronautics and Space Administration (NASA). This announcement sparked a global outpouring of grief that demonstrated people understood and related to the robot in a notably human-like manner. In short, it had been given a collectively understood persona. This paper presents a study of 100 digital postcards created by users on a NASA website that demonstrate the ways in which people expressed love, grief, hope, and thanks for Opportunity’s fourteen years of operation on another planet. In presenting this case study, the paper argues that certain personas are collective achievements. This is especially likely to occur for robots and other inanimate objects which have no centrally controlled or developed persona. The paper is situated within existing persona studies literature to extend and stretch the definition of persona studies and therefore expand the field in productive ways to incorporate the study of non-human personas.
The human genome project and its search for factors underlying human diseases has fostered a major human research effort. Therefore, unsurprisingly, in recent years we have observed an increasing ...number of studies on human islet cells, including disease approaches focusing on type 1 and type 2 diabetes. Yet, the field of islet and diabetes research relies on the legacy of rodent-based investigations, which have proven difficult to translate to humans, particularly in type 1 diabetes. Whole islet physiology and pathology may differ between rodents and humans, and thus a comprehensive cross-species as well as species-specific view on islet research is much needed. In this review we summarise the current knowledge of interspecies islet cytoarchitecture, and discuss its potential impact on islet function and future perspectives in islet pathophysiology research.
Technologies for silencing the electrical activity of genetically targeted neurons in the brain are important for assessing the contribution of specific cell types and pathways toward behaviors and ...pathologies. Recently we found that archaerhodopsin-3 from Halorubrum sodomense (Arch), a light-driven outward proton pump, when genetically expressed in neurons, enables them to be powerfully, transiently, and repeatedly silenced in response to pulses of light. Because of the impressive characteristics of Arch, we explored the optogenetic utility of opsins with high sequence homology to Arch, from archaea of the Halorubrum genus. We found that the archaerhodopsin from Halorubrum strain TP009, which we named ArchT, could mediate photocurrents of similar maximum amplitude to those of Arch (∼900 pA in vitro), but with a >3-fold improvement in light sensitivity over Arch, most notably in the optogenetic range of 1-10 mW/mm(2), equating to >2× increase in brain tissue volume addressed by a typical single optical fiber. Upon expression in mouse or rhesus macaque cortical neurons, ArchT expressed well on neuronal membranes, including excellent trafficking for long distances down neuronal axons. The high light sensitivity prompted us to explore ArchT use in the cortex of the rhesus macaque. Optical perturbation of ArchT-expressing neurons in the brain of an awake rhesus macaque resulted in a rapid and complete (∼100%) silencing of most recorded cells, with suppressed cells achieving a median firing rate of 0 spikes/s upon illumination. A small population of neurons showed increased firing rates at long latencies following the onset of light stimulation, suggesting the existence of a mechanism of network-level neural activity balancing. The powerful net suppression of activity suggests that ArchT silencing technology might be of great use not only in the causal analysis of neural circuits, but may have therapeutic applications.
Dendritic cells (DCs) were initially defined as mononuclear phagocytes with a dendritic morphology and an exquisite efficiency for naïve T-cell activation. DC encompass several subsets initially ...identified by their expression of specific cell surface molecules and later shown to excel in distinct functions and to develop under the instruction of different transcription factors or cytokines. Very few cell surface molecules are expressed in a specific manner on any immune cell type. Hence, to identify cell types, the sole use of a small number of cell surface markers in classical flow cytometry can be deceiving. Moreover, the markers currently used to define mononuclear phagocyte subsets vary depending on the tissue and animal species studied and even between laboratories. This has led to confusion in the definition of DC subset identity and in their attribution of specific functions. There is a strong need to identify a rigorous and consensus way to define mononuclear phagocyte subsets, with precise guidelines potentially applicable throughout tissues and species. We will discuss the advantages, drawbacks, and complementarities of different methodologies: cell surface phenotyping, ontogeny, functional characterization, and molecular profiling. We will advocate that gene expression profiling is a very rigorous, largely unbiased and accessible method to define the identity of mononuclear phagocyte subsets, which strengthens and refines surface phenotyping. It is uniquely powerful to yield new, experimentally testable, hypotheses on the ontogeny or functions of mononuclear phagocyte subsets, their molecular regulation, and their evolutionary conservation. We propose defining cell populations based on a combination of cell surface phenotyping, expression analysis of hallmark genes, and robust functional assays, in order to reach a consensus and integrate faster the huge but scattered knowledge accumulated by different laboratories on different cell types, organs, and species.
How do patterns of neural activity in the motor cortex contribute to the planning of a movement? A recent theory developed for single movements proposes that the motor cortex acts as a dynamical ...system whose initial state is optimized during the preparatory phase of the movement. This theory makes important yet untested predictions about preparatory dynamics in more complex behavioral settings. Here, we analyze preparatory activity in non-human primates planning not one but two movements simultaneously. As predicted by the theory, we find that parallel planning is achieved by adjusting preparatory activity within an optimal subspace to an intermediate state reflecting a trade-off between the two movements. The theory quantitatively accounts for the relationship between this intermediate state and fluctuations in the animals’ behavior down at the trial level. These results uncover a simple mechanism for planning multiple movements in parallel and further point to motor planning as a controlled dynamical process.
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•Monkeys plan two grasping movements individually or in parallel•Motor cortex encodes individual grips with different preparatory states•Parallel planning is associated with an intermediate preparatory state•This intermediate state reflects an optimal trade-off between the two grips
Meirhaeghe et al. show that, when preparing two movements in parallel, motor cortical activity reaches an intermediate preparatory state in between the states associated with each movement planned separately. This intermediate state constitutes the optimal initial condition to quickly execute either one of the two movements.
To investigate the effects of neonatal hippocampal lesions on the microstructural integrity of the corpus callosum (CC) in adulthood, macaque monkeys (n = 5) with neonatal bilateral neurotoxic ...hippocampal lesion (Neo‐Hibo) and sham‐operated controls (Neo‐C, n = 5) were scanned using magnetic resonance diffusion tensor imaging (DTI) technique at 8–10 years old. CC was segmented into seven regionsgrouped into anterior CC (rostrum, genu, rostral body and anterior midbody) and posterior CC (posterior midbody, isthmus and splenium) for data analysis. Associated transcallosal fiber tracts were delineated using probabilistic tractography and evaluated with tract‐based spatial statistics (TBSS). Neo‐Hibo lesions resulted in significant increased diffusivity indices (mean, axial and radial diffusivity) in CC posterior segments. Also, significant decreased fractional anisotropy (FA) and increased diffusivity indices were seen in the associated transcallosal fiber tracts proximal to motor, posterior parietal and retrosplenial cortices. In Neo‐Hibo animals, increased mean diffusivity (MD) in posterior midbody negatively correlated with reduction of CC surface areaand the magnitude of their memory impairments was significantly correlated with FA in transcallosal fiber tracts across splenium. Although no microstructural changes were observed in CC anterior segments, changes in FA values and diffusivity indices were observed in the white matter fibers of the ventromedial prefrontal cortex. Thus, Neo‐H lesions resulted in enduring degradation in transcallosal fibers proximal to parietal and retrosplenial cortices, and hemispheric connections through posterior CC. The findings may provide complementary information for understanding the neural substrate of behavioral and cognitive deficits observed in patients with early insult to the hippocampus.
•A 3D template of the marmoset cortex representing the average of 20 individuals.•The template is based on Nissl stain and preserves information about cortical layers.•Probabilistic mapping of areas, ...cortical thickness, and layer intensity profiles.•Includes spatial transformations to other marmoset brain templates.
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The rapid adoption of marmosets in neuroscience has created a demand for three dimensional (3D) atlases of the brain of this species to facilitate data integration in a common reference space. We report on a new open access template of the marmoset cortex (the Nencki–Monash, or NM template), representing a morphological average of 20 brains of young adult individuals, obtained by 3D reconstructions generated from Nissl-stained serial sections. The method used to generate the template takes into account morphological features of the individual brains, as well as the borders of clearly defined cytoarchitectural areas. This has resulted in a resource which allows direct estimates of the most likely coordinates of each cortical area, as well as quantification of the margins of error involved in assigning voxels to areas, and preserves quantitative information about the laminar structure of the cortex. We provide spatial transformations between the NM and other available marmoset brain templates, thus enabling integration with magnetic resonance imaging (MRI) and tracer-based connectivity data. The NM template combines some of the main advantages of histology-based atlases (e.g. information about the cytoarchitectural structure) with features more commonly associated with MRI-based templates (isotropic nature of the dataset, and probabilistic analyses). The underlying workflow may be found useful in the future development of 3D brain atlases that incorporate information about the variability of areas in species for which it may be impractical to ensure homogeneity of the sample in terms of age, sex and genetic background.
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