In this study, core-shell nanofibers were produced by using hydrophilic polyvinylpyrrolidone (PVP) polymer in the core and hydrophobic poly(e-caprolactone) (PCL) polymer in the shell. Essential oil ...added nanofiber structures were developed by adding thyme oil (TEO) and borage oil (BO) in the PVP core part by using Triton X 100 (TX-100) as the surfactant. 8% PVP-8% PCL nanofibers were produced by adding TEO, BO and a 1:1 volume/volume mixture of these two (TEO:BO) to the PVP solution. Addition of essential oil and surfactant to the solutions resulted in different conductivity and viscosity values. SEM images were analyzed and it was observed that nanofiber diameters increased when essential oil and surfactant were added to the core of the coaxial nanofibers. Pristine, TEO-added, TEO:BO added and BO-added nanofibers were calculated as 145 ± 66, 233 ± 150, 245 ± 165 and 300 ± 124 nm, respectively. Besides, water contact angle measurements showed that TX-100 and essential oil additives caused high hydrophilization of nanofiber by changing the hydrophobic nature of PCL. While the contact angle of the 8% PVP-8% PCL sample without additives were 98°, the contact angle of the oil and surfactant containing samples were measured as 0°. In conclusion, it was observed that the nanofiber morphology and surface properties changed when different essential oils and surfactant were added to the core-shell nanofibers.
Tkivno inženjerstvo dobra je alternativa za razvoj tkiva ili potencijalnih organa iz pacijentova vlastitog staničnog materijala, a kako bi se smanjio problem nedostatka organa za transplantaciju. ...Elektroispredeni materijali su dobri kandidati kod primjene u biomedicini tj. kao nosači za uzgoj tkivnih stanica. Kod regeneracije tkiva mogu dodatno prenositi lijekove kontrolirano prema terapiji. U ovom je radu istraživano kontrolirano otpuštanje antibiotika Cefuroxima (CFU) koji se upotrebljava u terapiji okularnog tkiva. Elektroispredeni su polikaprolaktonski nosači uz dodatak CFU-a u udjelima od 1, 2, 5 i 10 mas %. Uspješna kapsulacija antibiotika potvrđena je pojavom novih karakterističnih pikova u FTIR spektrima elektroispredenih mješavina. Dodatkom antibiotika i povećanjem njegove koncentracije dobivaju se vlakna homogenijeg izgleda s manjim brojem deformacija po duljini vlakna. UV-VIS spektrofotometrijom praćeno je vrijeme otpuštanja antibiotika iz elektroispredenih PCL/CFU nosača. Dobiveno je povećanje apsorbancije antibiotika s vremenom i porastom koncentracije lijeka u nosaču.
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