Provider: - Institution: - Data provided by Europeana Collections- Il busto trova stretta analogia con due busti deposti in una tomba a semicamera di Egnazia; le analogie si estendono alla forma ...complessiva, allimpostazione del volto e della capigliatura, alla posa delle mani; la sepoltura si data al III secolo ma fu usata fino agli inizi del I secolo a.C. DallItalia del sud è lesemplare al Louvre, datato al V secolo a.C.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
This paper describes the Southern Pomo switch-reference system used in narrative texts. In this genre, switch-reference is shown to be canonical: suffixes applied to dependent verbs indicate whether ...or not the subject of the dependent verb is shared with a single TAM-bearing main verb. This system is compared with the switch-reference systems (or lack thereof) reported for the other six Pomoan languages. Only Kashaya Pomo is reported to have the same system. The other five Pomoan languages have different systems or none at all. It is asserted that switch-reference was not present in Proto-Pomo and developed in different ways in a subset of offspring languages through entirely internal changes without influence from non-Pomoan language contact. In those languages where switch-reference (whether canonical or not) developed, systems with dedicated bound switch-reference morphemes are hypothesized to have been elaborated around the same two Proto-Pomo suffixes, *-Vn and *-pʰi.
Giudizio di Paride Maestro del Giudizio di Paride (1430 - 1440)
1430 - 1440, sec. XV
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Provider: - Institution: - Data provided by Europeana Collections- Iconograficamente la superficie del desco da parte viene divisa in tre episodi, di cui quello più significativo, Paride che consegna ...ad Afrodite il pomo delle Esperidi, occupa la parte centrale. A destra, in alto vediamo il principe a colloquio con il suo compagno pastore in mezzo al gregge di arieti bianchi e neri, a sinistra le tre dee Afrodite, Era, Atene. Sedute ai margini di un boschetto, mentre su di loro si libra Eris, dea della Discordia, nell'atto di gettare il pomo : subito sotto due fanciulli che conversano in prossimità di un abbeveratorio, le cui funzione compositive è quella di bilanciare il gruppo degli arieti. Si tratta di una raffinata realizzazione di tono favolistico che ben pochi riscontri stilistici trova in opere analoghe se non nel tondo Le Roy, opera dello stesso artista, che è una replica con minime varianti di questo desco. Evidenti i richiami stilistici alle eleganze del Gotico internazionale che tende a permanere in questi oggetti di uso domestico al di là delle evoluzioni delle realizzazioni pittoriche di più vasto respiro.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Incomplete lineage sorting can cause incongruencies of the overall species-level phylogenetic tree with the phylogenetic trees for individual genes or genomic segments. If these incongruencies are ...not accounted for, it is possible to incur several biases in species tree estimation. Here, we present a simple maximum likelihood approach that accounts for ancestral variation and incomplete lineage sorting. We use a POlymorphisms-aware phylogenetic MOdel (PoMo) that we have recently shown to efficiently estimate mutation rates and fixation biases from within and between-species variation data. We extend this model to perform efficient estimation of species trees. We test the performance of PoMo in several different scenarios of incomplete lineage sorting using simulations and compare it with existing methods both in accuracy and computational speed. In contrast to other approaches, our model does not use coalescent theory but is alíele frequency based. We show that PoMo is well suited for genome-wide species tree estimation and that on such data it is more accurate than previous approaches.
•An Eudesmic conjugate of manganese polyoxomolybdate (EU2POMo) was synthesized.•The optimized structural properties of POMo & EU2POMo were investigated by DFT.•Eu2POMo has appropriate anti-cancer ...activity against breast cancer cell lines.•Eu2POMo was safer than free POMo on HUVEC cell line (normal cells).•Eu2POMo has improved the apoptosis ratio in compare to the free POMo.
In this work, trimethylated gallic acid (Eudesmic acid, EU) was selected for the synthesis of an organo-conjugate (EU2POMo) from TRIS modified Anderson-type manganese polyoxomolybdate (POMo) for the first time.
EU2POMo was synthesized through amide bonding between POMo and EU using carbodiimide coupling strategy. Some of the quantum chemical properties of POMo and EU2POMo beside the DFT and TD-DFT calculations were done using the Gaussian program. The cytotoxicity was studied on breast cancer cell lines (MCF-7 and MDA-MB-231) comparing the Human Umbilical Vein Endothelial Cell line (HUVEC) using the MTT method. The cellular uptake was determined using the ICP-MS method, and the apoptosis value was checked by the flow cytometry technique on the MDA-MB-231 cell line.
The structure was approved by FTIR, NMR spectroscopy as well as elemental analysis. Quantum chemical calculations proposed better stability and lower chemical potential for EU2POMo, and internal energy and dipole moment were higher in the EU2POMo. Both POMo and EU2POMo showed reasonable anti-cancer effects on breast cancer cell lines (MCF-7 and MDA-MB-231), and the results were somewhat in favor of POMo. Interestingly, EU2POMo showed no significant cytotoxicity on the HUVEC and was safer than POMo. Cellular uptake (33.5% versus 29.2%) and apoptosis value (28% versus 15%) in the case of EU2POMo were slightly better than POMo.
In conclusion, this study aimed to introduce a novel, potent and safe anti-cancer Anderson type polyoxometalate to cancer studies. Based on results, this conjugate has sufficient potential for further cancer chemotherapy assessments, specifically breast cancer.
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This study aimed to develop novel pH-sensitive Glucosamine (Glu) targeted Polydopamine (PDA) coated mesoporous silica (SBA-15) nanoparticles (NPs) for selective delivery of anticancer Anderson-type ...manganese polyoxomolybdate (POMo) to breast cancer.
The POMo@SBA-PDA-Glu NPs were prepared via direct hydrothermal synthesis of SBA, POMo loading, in situ PDA post functionalization, and Glu anchoring; the chemical structures were fully studied by different characterisation methods. The anticancer activity was studied by MTT method and Annexin V-FITC apoptosis detection kit.
The optimised NPs had a hydrodynamic size (HS) of 195 nm, a zeta potential (ZP) of −18.9 mV, a loading content percent (LC%) of 45%, and a pH-responsive release profile. The targeted NPs showed increased anticancer activity against breast cancer cell lines compared to the free POMo with the highest cellular uptake and apoptosis level in the MDA-MB-231 cells.
POMo@SBA-PDA-Glu NPs could be a promising anticancer candidate for further studies.
Despite the promising anti-cancer properties of the polyoxometalates (POMs) compound, they have not yet been reported for clinical use due to their general toxicity. This study reports the synthesis ...of tocopherol succinate (TS)-polyoxomolybdate (POMo) conjugate (T
2
POMo) as a novel organic–inorganic hybrid conjugate of POMo and evaluating its anti-cancer properties in vitro. The aim was to introduce a more potent derivative with less general toxicity than initial POMo to cancer treatment studies. The T
2
POMo conjugate was synthesized using amide bond formation between POMo and TS based on the carbodiimide strategy. The chemical structure of T
2
POMo conjugate was fully investigated and confirmed using spectroscopy and elemental analysis techniques. The anti-cancer properties of T
2
POMo conjugate were evaluated on Brest (MCF-7) and prostate cancer (LNCAP) cell lines carefully by the MTT protocol, and the general toxicity was studied on human umbilical vein endothelial cells (HUVEC) similarly. Finally, the quantity of induced apoptosis was carefully evaluated using the flow cytometry technique for the T
2
POMo conjugate compared to POMo. The cytotoxicity studies showed that tocopherol succinate conjugation altered and regulated the activity and seems to induce great synergistic cytotoxic effects on cancerous cell lines. The half-maximal
inhibitory concentration
(IC50) on the MCF-7 cell line was about 167.3 μg/mL, and on the LNCAP cell line was about 234.1 μg/mL. The cytotoxicity of T
2
POMo was significantly greater than that of POMo, and the toxic effects on normal cells were significantly reduced. Flow cytometry results showed that the hybrid conjugate could produce about 61% of apoptosis in the MCF-7 cell line than POMo (36%) alone. Therefore, tocopherol succinate hybrid conjugate (T
2
POMo) can be introduced as a promising potent anti-cancer agent to further pre-clinical studies.
Created for general and scholarly audiences alike, this volume offers ten of the best recent plays by and about gay men, all of which have been successfully produced and critically acclaimed in the ...United States and England. The playwrights, who reflect multicultural origins ranging from Anglo to African American and Latino, have crafted powerful and insightful depictions of the roles gay men play in gender politics.
Each play is explosive, politically and socially relevant, and enlightening, whether it be Martin Sherman's much-praised A Madhouse in Goa or the avante-garde Pomo Afro Homos' Dark Fruit. The first to offer such a diversity of voices, this collection also crosses generational borders. Included are two of the first and most important modern gay play-wrights—Martin Sherman and Peter Gill—as well as exciting younger dramatists who have emerged in the "gay nineties."
Illustrating the sexual politics and events that have swirled through mainstream society since the Stonewall rebellion in the 1960s—AIDS, homophobia, transgendering, discrimination, violence—these plays offer essential and direct articulation of the human lives involved. Each of these plays in its own unique way deeply investigates the pain, sorrow, joy, and beauty of being gay in a predominantly heterosexual world.
A collection of ten contemporary plays, by writers who reflect a range of cultural origins, about male homosexuality.
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