ABSTRAK Pendahuluan: Necrotizing ulcerative stomatitis (NUS) merupakan penyakit inflamasi pada rongga mulut, ditandai oleh ulser nekrosis akut, berkembang cepat serta menyebabkan kerusakan masif pada ...jaringan. NUS dapat berkembang dari kondisi necrotizing ulcerative gingivitis (NUG) dan necrotizing ulcerative periodontitis (NUP). NUS dapat disertai infeksi lain, salah satunya infeksi herpes simplex tipe 1 (HSV-1). Infeksi HSV-1 dan NUS pada anak dengan anemia aplastik jarang ditemukan. Anemia aplastik merupakan kelainan hematologi, ditandai dengan hipoplastik/aplasia sumsum tulang dan pansitopenia, sehingga menurunkan resistensi host terhadap infeksi. Gingivostomatitis herpetik primer memudahkan perkembangan bakteri komensal seperti bakteri Fusiform, Spirochetes dan Pseudomonas aeruginosa menjadi patogen pada kondisi imunosupresif sehingga meningkatkan progresivitas penyakit periodontal menjadi NUS. Tujuan laporan kasus ini adalah menjelaskan tatalaksana infeksi HSV-1 dan NUS pada anak dengan anemia aplastik. Laporan kasus: Seorang anak perempuan usia 3 tahun dengan diagnosis anemia aplastik dan febrile neutropenia, dirujuk oleh divisi Hematologi-onkologi anak Rumah Sakit Dr. Hasan sadikin (RSHS) Bandung dengan keluhan pembengkakan pada bibir dan stomatitis. Hasil pemeriksaan darah menunjukan adanya pansitopenia dan pemeriksaan anti HSV-1 IgG reaktif. Diagnosis terkait kondisi bibir dan mulut pasien adalah Infeksi HSV-1 dan NUS. Tatalaksana yang dilakukan adalah debridement dengan Hidrogen peroksida 1,5% (H2O2 1,5%), kontrol plak dengan chlorhexidine digluconate 0,12% dan multivitamin. Pembengkakan mulai membaik setelah 3 hari debridement serta memberikan hasil yang signifikan setelah 1 bulan perawatan. Simpulan: Tatalaksana berupa peningkatan oral hygiene dan terapi antiseptik dapat memperbaiki kondisi infeksi HSV-1 dan NUS, khususnya pada pasien dengan kondisi imunosupresif seperti anemia aplastik. Kata kunci: febrile neutropenia; stomatitis; herpes simpleks; anemia; spirochetes ABSTRACT Introduction: Necrotising ulcerative stomatitis (NUS) is an inflammatory disease of the oral cavity, characterised by acute necrotising ulcers, proliferating, and causing massive tissue damage. NUS can be developed from necrotising ulcerative gingivitis (NUG) and necrotising ulcerative periodontitis (NUP). NUS can be accompanied by other infections, such as herpes simplex type 1 (HSV-1) infection. However, HSV-1 and NUS infections in children with aplastic anaemia are rare. Aplastic anemia is a haematological disorder characterised by hypoplastic/bone marrow aplasia and pancytopenia, reducing the host's resistance to infection. Primary herpetic gingivostomatitis facilitates the development of commensal bacteria such as Fusiform bacteria, Spirochetes and Pseudomonas aeruginosa to become pathogens under immunosuppressive conditions, thereby increasing the progression of periodontal disease to NUS. This case report aims to describe the management of HSV-1 and NUS infections in children with aplastic anemia. Case report: A 3-year-old female child diagnosed with aplastic anaemia and febrile neutropenia was referred by the paediatric haematology-oncology division of Dr Hasan Sadikin Hospital (RSHS) Bandung with complaints of swelling of the lips and stomatitis. Blood test results showed pancytopenia and reactive anti-HSV-1 IgG examination. The diagnosis related to the patient's lips and mouth condition was HSV-1 and NUS infection. The treatment is debridement with 1.5% hydrogen peroxide (H2O2 1.5%), plaque control with 0.12% chlorhexidine digluconate and multivitamins. After three days of debridement, the swelling started to improve and gave significant results after one month of treatment. Conclusion: Management of improving oral hygiene and antiseptic therapy can improve the condition of HSV-1 and NUS infections, especially in patients with immunosuppressive conditions such as aplastic anemia. Keywords: febrile neutropenia; stomatitis; herpes simplex; anaemia; spirochetes
Mathematics is a means of communication science about patterns that are useful to practice thinking logically, critically, creative and innovative. The importance of mathematics in education is ...inversely related to the interest of students, because mathematics is considered to be difficult and tedious, it is necessary for the innovation in learning so that math seems easy and interesting, namely one of them with developing a learning media in the form of a video by using the app Sparkol's video scribe. The purpose of this research is learning media math using software Sparkol Video scribe on the main discussion of linear program simplex method, as well as test the feasibility and know the response of students to the media. This study uses a model ADDIE which includes 5 steps, namely: analysis (analyze), planning (design), development (development), implementation (implementation), and evaluation (evaluation). The feasibility of learning media obtained from the results of the validation by media experts and matter experts with the category and the attractiveness of the video data obtained from a questionnaire filled by the students include small class and large class and qualitatively qualified interesting.
Ensefalitis herpes simplex (EHS) seringkali berakibat fatal. Virus herpes simpleks (VHS)dapat menyerang semua umur tanpa perbedaan jenis kelamin. Angka kejadian EHSadalah 1:(250.000–500.000) ...populasi/tahun. Pada fase prodromal dapat ditemukanmalaise dan disertai demam selama 1-7 hari. Pasien mengalami penurunan kesadarandan kejang, dapat berupa kejang umum. Gejala neurologi umumnya ditemukanhemiparesis, sedangkan pemeriksaan darah tepi rutin pada EHS tidak efektif. EEG sangatmembantu bila ditemukan perlambatan fokal di daerah temporal atau fronto temporal.Titer antibodi terhadap VHS dapat diperiksa dari serum dan cairan serebrospinalis.Pengobatan VHS berupa terapi simtomatis dan suportif ditambah antivirus spesifik(acyclovir). Prognosis pasien EHS yang tidak diobati sangat buruk, sedangkan padapengobatan dini dengan acyclovir akan menurunkan mortalitas menjadi 28%.
Permasalahan penentuan jumlah produksi di suatu perusahaan sering dihadapi oleh suatu perusahaan. Faktor penyebabnya adalah jumlah barang yang diproduksi tidak sesuai dengan kebutuhan konsumen, ...sehingga terjadi penumpukan stok barang yang dapat mengakibatkan kerugian perusahaan. Penentuan jumlah produksi dapat diselesaikan dengan menggunakan model program linier. Beberapa cara menyelesaikan masalah dengan model program linier, diantaranya yaitu diselesaikan dengan Metode Simpleks. Metode simpleks menyelesaikan masalah optimasi dengan membangun tabel-tabel penyelesaian berdasarkan langkah-langkah tertentu sebelum penyusunan tabel fungsi kendala dan fungsi tujuan harus disesuaikan dengan ketentuan-ketentuannya. UKM Gerabah yang diambil dalam penelitian ini adalah UKM Dewi Sri Teracotta. UKM ini bergerak dalam bidang produksi dan penjualan barang kerajinan gerabah yang terbuat dari tanah liat atau sering disebut "Teracotta". Dengan keterbatasan sumber daya yang dimiliki itu Dewi Sri Teracotta ingin mengetahui berapa barang yang akan diproduksi setiap harinya dalam rangka memaksimumkan laba perusahaan. Beberapa faktor yang dihadapi maka dibuatlah Aplikasi Optimalisasi Produksi menggunakan Metode Simpleks untuk berbasis Web dengan menggunakan variabel jumlah jam kerja yang dibutuhkan, jumlah tanah liat yang dibutuhkan, jumlah laba atau keuntungan, batasan jam kerja, batasan bahan baku tanah liat. Hasil optimasi produksi yaitu berapa banyak suatu produk harus diproduksi berdasarkan keterbatasan bahan baku tanah liat dan jam kerja yang tersedia, serta keuntungan maksimal yang akan diterima perusahaan.
Purpose: The aim of this study is to compare the effects of acyclovir and penciclovir creams in the treatment of recurrent herpes labialis.
Materials and Methods: Seventy patients with pre-diagnosed ...recurrent herpes labialis lesions were enrolled in this study. Diagnosis was confirmed with HSV-1 IgM antibody test. Patients were separated under 2 treatment groups as acyclovir and penciclovir cream. Both agents were applied until complete healing of the lesions was seen. Burning, itching and bleeding scores; time of erythema, vesicles, ulceration, crusting and crust loss of the lesions were recorded. Pain values of the patients were recorded using a visual analog scale (VAS) and DASS-21 scale was used to measure emotional state related to depression, anxiety and stress.
Results: Pain level in the acyclovir group was significantly lower than the penciclovir group in the 3rd day, though with no difference in the following days. DASS-21 scores revealed signs of depression on 62.8% of the patients, anxiety on 34.2% of the patients, and stress on 41.4% of the patients in moderate or higher levels. While the pain level was higher in patients with high anxiety severity, it was observed that the pain level was low in patients with high stress intensity.
Conclusion: Although it is not possible to cure recurrent herpes labialis completely, any methods and drugs that shorten the healing time of the lesion and reduce pain and discomfort gains importance. Our study showed that acyclovir is superior in reducing pain.
Giriş: Bu çalışmanın amacı, rekürrent herpes labialisin topikal tedavisinde asiklovir ve pensiklovir etken madde içeren kremlerin etkilerini karşılaştırmaktır.
Gereç ve Yöntem: Çalışmamıza rekürrent herpes labialis tanı konmuş lezyonu olan 70 hasta dahil edildi. Teşhis HSV-1 IgM antikor testi ile doğrulandı. Hastalar asiklovir ve pensiklovir etken maddesi içeren kremlerin kullanıldığı iki tedavi grubuna ayrıldı. Her iki ajan lezyonlarda tam iyileşme görülene kadar uygulandı. Yanma, kaşıntı ve kanama skorları; lezyonların kızarıklık, vezikül, ülserasyon, kabuklanma ve kabuk kaybı zamanları kaydedildi. Hastaların ağrı değerleri görsel analog skala (VAS) ile kaydedildi ve depresyon, anksiyete ve stres ile ilgili duygusal durumu ölçmek için DASS-21 skalası kullanıldı.
Bulgular: Asiklovir grubundaki ağrı düzeyi, sadece üçüncü günde pensiklovir grubuna göre anlamlı derecede düşüktü. DASS-21 skorları, hastaların %62,8'inde depresyon, %34,2'sinde anksiyete ve %41,4'ünde orta ve yüksek düzeyde stres belirtisi gösterdi. Anksiyete şiddeti yüksek hastalarda ağrı düzeyleri yüksek iken, stres yoğunluğu yüksek hastalarda ağrı düzeyinin düşük olduğu görüldü.
Sonuç: Rekürrent herpes labialisin tamamen tedavisi mümkün olmamakla birlikte lezyonun iyileşme süresini kısaltan, ağrı ve rahatsızlığı azaltan her türlü yöntem ve ilaç önem kazanmaktadır. Bu bağlamda çalışmamız, asiklovir etken madde içeren ajanın, ağrıyı azaltmada pensiklovir etken maddesi içeren ajana göre daha üstün olduğunu göstermiştir.
PT. Industri Sandang Nusantara Pata! Secang Magelang is some factory that regarding in manufactur sector which thread producting. For this time the factory have a problem with stacking same kind of ...product and in the other way less another product. This case cause that factory use product scheduling based on experience and reckoned of selling in last period. Connected with this problem, the case is how to make a good schedule in order that factory could be completing consumer demand and decided some main product schedule with simpleks methode.The articulate in factory for this time is reguler employee 65 persons. If reguler employee is not enaugh, then there are overtime job (maximal 2 hour/days), and if still not enaugh too, then used subcontract. Based on capacity of production, the number of maximal employee are 70 personsAccording to teoritis, with using of forecasting and agregat planning, the factory's problem can be done. This forecasting used to productin supossing in about to many periods. With use simpleks methode can be planning the number of employee. In order that, the main production can be made.Analyst result get that demand fluktuation for R 30/1, PR 30/1 products use Moving Average Linear Trend (3) methode, R 24/ 1, R I 11, PR 40/l products using Moving Average Linear Trend (5) methode, PR 45/l product using Linear Regression methode. Value analyst with based on forecasting result for future 12 periods, supposed that factory will pay for Rp. 460.340.000,• After applying Linear Programming giftotal cost Rp. 450.164.576,-. Thrifting Rp. 10.175.424,- or 2,2%. Sensitivity analyst made cost to be Rp. 448.651.040,-, thrifting Rp. 11.688.960,- or 2,5% at the number of regular employees 66 persons.
Uvjeti globalne konkurencije na suvremenom tržištu određuju konkurentsku
prednost poduzeća. Konkurentska prednost podrazumijeva primjenu učinkovitijih i
inovativnijih proizvodnih procesa i metoda. ...Mnogobrojni činitelji poslovanja, interni i eksterni,
nameću potrebu za utvrđivanjem i izborom različitih varijanti poslovanja, pri čemu je važno
izabrati odgovarajuću varijantu iz skupa raspoloživih rješenja. Čim se ciljevi poslovanja
ekonomskih subjekata mogu kvantitativno izraziti, za donošenje optimalnih poslovnih odluka
vrlo se efikasno koriste različiti ekonomsko - matematički modeli.
Problem ovoga istraživanja očituje se u utvrđivanju efikasnosti ekonomsko - matematičkih
modela i metoda u rješavanju problema odlučivanja unutar maloga poduzeća. Iz spomenutoga
proizlazi polazna hipoteza ovog istraživanja: Primjena metoda linearnoga programiranja
omogućava optimizaciju poslovnoga rezultata u ograničenim uvjetima poslovanja maloga
poduzeća.
Uvažavajući uvjete poslovanja, definirana su tri modela linearnoga programiranja, te je pri
utvrđivanju optimalnoga asortimana poslovnoga subjekta korištena simpleks metoda. Rezultati
empirijskoga primjera pokazuju da primjenom modela linearnoga programiranja donositelj
odluke ima mogućnost upoznati se s mogućim efektima odluke, i temeljem toga, a u skladu sa
svojim ciljevima, odabrati optimalan način rješavanja konkretnoga poslovnoga problema.
Fatal Herpes Simplex Virus Infection in Darier’s Disease Altunışık, Nihal; Inonu University, Department of Dermatology, Malatya, Turkey; Saraç, Gülbahar; Malatya State Hospital, Dermatology Clinic, Malatya, Turkey; Demirdağ, Hatice Gamze; Malatya State Hospital, Dermatology Clinic, Malatya, Turkey ...
Inönü Üniversitesi Turgut Özal Tıp Merkezi dergisi,
06/2015, Letnik:
22, Številka:
1
Journal Article
AbstractDarier disease is an autosomal dominant disorder characterized by small, hyperkeratotic papules localised on the trunk especially in the seborrheic regions. Vegetation and infections in the ...intertriginous areas are common in this disease while treatment is not usually satisfying. While the urea or lactic acid containing moisturizers, topical steroids, and topical retinoids are used in mild cases, systemic retinoids are preferred in severe cases. Kaposi varicelliform eruption caused by herpes simplex virus is rare but a well-defined complication. Clinical findings of this viral infection, which are usually uncommon, may delay diagnosis and treatment. Here, we report the case of a patient with Darier’s disease treated with corticosteroids who later developed fatal herpes simplex virus infection despite the aciclovir therapy.Key Words: Darier’s Disease; Herpes Simplex Infection; Fatal Herpes Simplex Infection. Darier Hastalığında Fatal Herpes Simpleks Virüs Enfeksiyonu Özet Darier Hastalığı, otozomal dominant kalıtımla geçen, klinik olarak gövdede ve özellikle seboreik alanlarda lokalize, küçük, hiperkeratotik papüllerle karakterize bir hastalıktır. Hastalıkta intertriginöz alanlarda vejetasyon ve infeksiyonlar sıktır. Tedavisi genellikle tatmin edici değildir. Hafif olgularda üre veya laktik asit içeren nemlendiriciler, topikal steroidler, topikal retinoidler kullanılırken, şiddetli olgularda sistemik retinoidler tercih edilir. Herpes simpleks virüsünün neden olduğu Kaposinin variselliform erüpsiyonu hastalığın nadir görülen fakat iyi tanımlanmış bir komplikasyonudur. Bu viral enfeksiyonun alışılmışın dışındaki klinik bulguları, sıklıkla tanıda ve tedavinin verilmesinde gecikmelere neden olabilir. Burada kortikosteroid tedavisi alan bir Darier hastasında takipleri esnasında gelişen ve asiklovir tedavisine rağmen fatal seyreden, herpes simpleks virüs enfeksiyonu sunulmaktadır.Anahtar Kelimeler: Darier Hastalığı; Herpes Simpleks Enfeksiyonu; Fatal Herpes Simpleks Enfeksiyonu.
Darier disease is an autosomal dominant disorder characterized by small, hyperkeratotic papules localised on the trunk especially in the seborrheic regions. Vegetation and infections in the intertriginous areas are common in this disease while treatment is not usually satisfying. While the urea or lactic acid containing moisturizers, topical steroids, and topical retinoids are used in mild cases, systemic retinoids are preferred in severe cases. Kaposi varicelliform eruption caused by herpes simplex virus is rare but a well-defined complication. Clinical findings of this viral infection, which are usually uncommon, may delay diagnosis and treatment. Here, we report the case of a patient with Darier’s disease treated with corticosteroids who later developed fatal herpes simplex virus infection despite the aciclovir therapy
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