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Univerzitetna knjižnica Maribor (UKM)
Knjižnica je med tednom odprta od 8. do 19. ure, ob sobotah od 9. do 13. ure. Čitalnica ČUK je odprta od ponedeljka do sobote od 12. do 24. ure, ob nedeljah od 18. do 24. ure. Informacije: 02 25 07 431, ukm@um.si
  • Neurohypophysial peptide hormone receptors: glycosylation, ligand recognition and effector coupling = Receptorji nevrofizioloških peptidnih hormonov: glikozilacija, prepoznavanje ligandov in spojitev z efektorji
    Wheatley, Mark ; Hawtin, Stuart R ; Howard, Helen C
    The effects of the neurohypophysial peptide hormones vasopressin (AVP) and oxytocin (OT) are mediated by a family of related G-protein-coupled receptors.We have investigated the structure and ... function of these receptors using a combination of site-directed mutagenesis and recombinant expression incultured HEK 293T cells. Receptor constructs were characterised pharmacologically using radioligand binding and second messenger assays. Data establish that ligand:receptor interaction involves extracellular domains and that a conserved acidic residue in transmembrane helix 2 is important for receptor activation. Using a cell-free translation system, the glycoprotein nature of the V1a subtype of vasopressin receptor is analysed and the importance of this glycosylation for efficient receptor expression is revealed. Overall, this study highllights the importance of certain residues within the receptor structure to normal receptor functioning.
    Vir: Acta biologica slovenica : ABS. - ISSN 1408-3671 (Letn. 43, št. 1/2, 2000, str. 143-146)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2000
    Jezik - angleški
    COBISS.SI-ID - 13145817

vir: Acta biologica slovenica : ABS. - ISSN 1408-3671 (Letn. 43, št. 1/2, 2000, str. 143-146)

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