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  • Motnje v delovanju endotelija in ateroskleroza = Endothelial dysfunction and atherosclerosis
    Poredoš, Pavel
    Healthy endothelium plays a central role in cardiovascular control. Therefore,endothelial dysfunction (ED), which is characterized by an imbalancebetween relaxing and contracting factors, ... procoagulant and anticoagulant substances, and between proinflammatory and antiinflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Endothelial dysfunction is ciosely related to different risk factors of atherosclerosis, to their intensity and their duration. The involvement o f risk factors in ED is also supported by results of intervention studies that showed regression of ED with treatment o f risk factors. The common denominator whereby different risk factors cause ED is most probably increased oxidative stress and/or inflammation. Endothelial dysfunction promotes atherosclerosis and probably plays an important role in the development o f thrombotic complications in the late stages of the disease. As ED is a key underlying factor in the atherosclerotic process, markers of endothelial abnormalities have been sought. Detection of ED is based on tests of endothelium dependent vasomotion (dilation capability of peripheral and coronary arteries) and on circulating markers of endothelial function (endothelin-1, von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, adhesion molecules). Using these tests it is possible to follow the dose-response of harmful effects of risk factors, and the effects of preventive procedures on vessel wall function.
    Vir: Krka v medicini in farmaciji. - ISSN 0351-6040 (Letn. 23, št. 33, 2002, str. 9-18)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - slovenski
    COBISS.SI-ID - 15333081

vir: Krka v medicini in farmaciji. - ISSN 0351-6040 (Letn. 23, št. 33, 2002, str. 9-18)

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