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Duplication, recombination and weak selection shape evolution at the MHC class II SLA-DRB1 locus in wild boars from the western BalkansStefanović, Milomir ...The Eurasian wild boar (Sus scrofa), having faced a population size reduction during the nineteenth and early twentieth centuries, is now experiencing a remarkable population recovery, not only ... confined to natural habitats alone, but also thriving in human-dominated environments. Previously, studies on wild boars predominantly relied on the analysis of supposedly neutral molecular markers (e.g., microsatellites and single nucleotide polymorphisms). In this study, a next-generation sequencing approach was used to examine the adaptive variation at the second exon of the SLA-DRB1 locus in 116 wild boars from the western Balkans. A total of 17 functional SLA-DRB1 alleles were detected which translated into 14 different amino-acid sequences. In 12 individuals, we observed alleles at duplicated SLA-DRB1 loci. Spatial analysis revealed the presence of three genetic clusters, albeit with relatively low overall differentiation (an average FST value of 0.012). Positive selection was detected on only one codon, as indicated by multiple tests, while the presence of shared alleles among related species suggested signals of trans-species polymorphism. Our results indicate the high MHC diversity at the SLA-DRB1 locus in wild boars from the Balkan Peninsula, shaped by a complex interplay of several non-exclusive mechanisms, including balancing selection, recombination, and gene duplications.Vir: Mammalian biology = Zeitschrift für Säugetierkunde (2001). - ISSN 1616-5047 (2024, str. 1-10)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 202169347
Avtor
Stefanović, Milomir |
Velickovic, Nevena |
Bončina, Aja |
Potušek, Sandra, 1989- |
Matić, Ivana, biologinja |
Djan, Mihajla |
Bužan, Elena
Teme
adaptive markers |
Balkan peninsula |
Ion Torrent |
immunogenetic |
MHC-DRB1 |
adaptivni molekularni označevalci |
Balkanski polotok |
Ion Torrent |
imunogenetika |
poglavitni histokompatibilnostni kompleks MHC-DRB1
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Stefanović, Milomir | ![]() |
Velickovic, Nevena | ![]() |
Bončina, Aja | 56934 |
Potušek, Sandra, 1989- | 52613 |
Matić, Ivana, biologinja | ![]() |
Djan, Mihajla | ![]() |
Bužan, Elena | 24375 |
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