E-viri
Recenzirano
-
Zhao, Xiao; Wang, Jennifer Rui; Dadu, Ramona; Busaidy, Naifa Lamki; Xu, Lei; Learned, Kim O; Chasen, Noah N; Vu, Thinh; Maniakas, Anastasios; Eguia, Arturo A; Diersing, Julia; Gross, Neil D; Goepfert, Ryan; Lai, Stephen Y; Hofmann, Marie-Claude; Ferrarotto, Renata; Lu, Charles; Gunn, Gary Brandon; Spiotto, Michael T; Subbiah, Vivek; Williams, Michelle D; Cabanillas, Maria E; Zafereo, Mark E
Thyroid (New York, N.Y.), 04/2023, Letnik: 33, Številka: 4Journal Article
The aim of this study was to describe the oncologic outcomes of patients with BRAF -mutated anaplastic thyroid cancer (ATC) who had neoadjuvant BRAF-directed therapy with subsequent surgery. For context, we also reviewed patients who received BRAF-directed therapy after surgery, and those who did not have surgery after BRAF-directed therapy. This was a single-center retrospective cohort study conducted at a tertiary care cancer center in Texas from 2017 to 2021. Fifty-seven consecutive patients with BRAF -mutated ATC and at least 1 month of BRAF-directed therapy were included. Primary outcomes were overall survival (OS) and progression-free survival (PFS). All patients had stage IVB (35%) or IVC (65%) ATC. Approximately 70% of patients treated with BRAF-directed therapy ultimately had surgical resection of residual disease. Patients who had neoadjuvant BRAF-directed therapy followed by surgery ( = 32) had 12-month OS of 93.6% confidence interval (CI) 84.9-100 and PFS of 84.4% CI 71.8-96.7. Patients who had surgery before BRAF-directed therapy ( = 12) had 12-month OS of 74.1% CI 48.7-99.5 and PFS of 50% CI 21.7-78.3. Finally, patients who did not receive surgery after BRAF-directed therapy ( = 13) had 12-month OS of 38.5% CI 12.1-64.9 and PFS of 15.4% CI 0-35.0. Neoadjuvant BRAF-directed therapy reduced tumor size, extent of surgery, and surgical morbidity score. Subgroup analysis suggested that any residual ATC in the surgical specimen was associated with significantly worse 12-month OS and PFS (OS = 83.3% CI 62.6-100, PFS = 61.5% CI 35.1-88) compared with patients with pathologic ATC complete response (OS = 100%, PFS = 100%). We observed that neoadjuvant BRAF-directed therapy reduced extent of surgery and surgical morbidity. While acknowledging potential selection bias, the 12-month OS rate appeared higher in patients who had BRAF-directed therapy followed by surgery as compared with BRAF-directed therapy without surgery; yet, it was not significantly different from surgery followed by BRAF-directed therapy. PFS appeared higher in patients treated with neoadjuvant BRAF-directed therapy relative to patients in the other groups. These promising results of neoadjuvant BRAF-directed therapy followed by surgery for BRAF-mutated ATC should be confirmed in prospective clinical trials.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.