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Van Maele, Laurye; Carnoy, Christophe; Cayet, Delphine; Songhet, Pascal; Dumoutier, Laure; Ferrero, Isabel; Janot, Laure; Erard, François; Bertout, Julie; Leger, Hélène; Sebbane, Florent; Benecke, Arndt; Renauld, Jean-Christophe; Hardt, Wolf-Dietrich; Ryffel, Bernhard; Sirard, Jean-Claude
The Journal of immunology (1950), 2010-Jul-15, Letnik: 185, Številka: 2Journal Article
In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 agonist flagellin induced swift and transient transcription of genes encoding IL-17 and IL-22 in lymphoid, gut, and lung tissues. This innate response also temporarily enhanced the expression of genes associated with the antimicrobial Th17 signature. The source of the Th17-related cytokines was identified as novel populations of CD3(neg)CD127(+) immune cells among which CD4-expressing cells resembling lymphoid tissue inducer cells. We also demonstrated that dendritic cells are essential for expression of Th17-related cytokines and so for stimulation of innate cells. These data define that TLR-induced activation of CD3(neg)CD127(+) cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues.
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