Sepsis is an emerging life-threatening entity and a worldwide epidemic. Nurses are in key positions to identify patients with sepsis, mobilize the medical team, and implement interventions. A study of self-assessed nurse competence was conducted to determine the influence of a specially designed sepsis education program on nurses' perceived ability to identify early, intervene, and care for patients with sepsis. The program was a multimodal design incorporating online interactive didactic presentations, video vignettes, pre- and postknowledge tests, and high-fidelity medical simulation scenarios. A sample of 82 critical care and emergency department nurses in a 1-year critical care nurse training program was used for this study. Pretest and posttest module knowledge scores and self-assessed competence data were collected and analyzed. No improvement in the overall self-assessed competence scores was found; however, self-perceived frequency of use of competence behaviors improved. Participants felt more competent on three sepsis-targeted statements, and posttest knowledge scores showed significant improvement.