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Morita, M; Al-Chalabi, A; Andersen, P M; Hosler, B; Sapp, P; Englund, E; Mitchell, J E; Habgood, J J; de Belleroche, J; Xi, J; Jongjaroenprasert, W; Horvitz, H R; Gunnarsson, L-G; Brown, Jr, R H
Neurology, 03/2006, Letnik: 66, Številka: 6Journal Article
To perform genetic linkage analysis in a family affected with ALS and frontotemporal dementia (FTD). The authors performed a genome-wide linkage analysis of a four-generation, 50-member Scandinavian family in which five individuals were diagnosed with ALS and nine with FTD. Linkage calculations assuming autosomal dominant inheritance of a single neurodegenerative disease manifesting as either ALS or FTD with age-dependent penetrance were performed. Further analyses for ALS alone and FTD alone were performed. A parametric logarithm of odds (lod) score of 2.0 or greater was required for further study of a potential locus and crossover (haplotype) analysis. A new ALS-FTD locus was identified between markers D9s1870 and D9s1791 on human chromosome 9p21.3-p13.3. A maximum multipoint lod score of 3.00 was obtained between markers D9s1121 and D9s2154. Crossover analysis indicates this region covers approximately 21.8 cM, or 14Mb. A locus on chromosome 9p21.3-p13.3 is linked to ALS-FTD.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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