Reliable nitrogen (N) fertilizer management indicators are essential for improving crop yields and minimizing environmental impacts for sustainable production. The objectives of this study were to assess the importance of major N management indicators (NMIs) for higher yield with low risks of environmental pollution in an intensive potato system under drip irrigation. Six drip-irrigated field experiments with no N application (Control), farmer practice (FP), and optimized N management (OM) based on N-balance, soil mineral N (Nmin), and target yield were conducted from 2018 to 2020 in Inner Mongolia, China. The response of NMIs to potato yield and yield-based environment impact indices (EIY) was evaluated by the random forest algorithm. The N input, N losses from N leaching, ammonia (NH3) volatilization, nitrous oxide (N2O) emission, N use efficiency (NUE), N surplus, and soil residual N after harvest were obtained to identify the best NMIs for high yield and minimal ecological impact. The N management practices in field experimental sites affected the importance of the order of NMIs on potato yield and EIY. The NUE and N leaching were identified as the highest importance scores and the most essential controlling variables to potato yield and EIY, respectively. The integrated NUE and N leaching indicator played a vital role in improving potato yield and reducing ecological impact. The OM treatment achieved 46.0%, 63.6%, and 64.6% lower in N application rate, N surplus, and reactive N loss, and 62.4% higher in NUE than the FP treatment while achieving equal potato yields, respectively. Those key NMIs can guide farmers in understanding their practice short comes to achieve both high productivity and environmental sustainability in intensive potato production systems under drip irrigation. •We assess the response of nitrogen (N) indicators to drip-irrigated potato system.•Yield and yield-base environment indices (EIY) were affected by NUE and leaching.•The N surplus was an effective indicator for controlling N losses.