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Li, Xiao-Hong; Zhong, Xiao-Mei; Lu, Li; Zheng, Wei; Wang, Shi-Bin; Rao, Wen-Wang; Wang, Shuai; Ng, Chee H; Ungvari, Gabor S; Wang, Gang; Xiang, Yu-Tao
Psychological medicine, 03/2020, Letnik: 50, Številka: 4Journal Article
Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated patients. A literature search in the international (PubMed, PsycINFO, and EMBASE) and Chinese (WanFang, Chinese National Knowledge Infrastructure, and Sinomed) databases was conducted. Prevalence estimates of agranulocytosis and related death in clozapine-treated patients were synthesized with the Comprehensive Meta-Analysis program using the random-effects model. Thirty-six studies with 260 948 clozapine-treated patients published between 1984 and 2018 were included in the meta-analysis. The overall prevalence of agranulocytosis and death caused by agranulocytosis were 0.4% (95% CI 0.3-0.6%) and 0.05% (95% CI 0.03-0.09%), respectively. The prevalence of agranulocytosis was moderated by sample size, study quality, year of publication, and that of data collection. The prevalence of clozapine-associated agranulocytosis is low. Agranulocytosis-related death appears rare.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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