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Kaplan, Muhammet Ali; Isikdogan, Abdurrahman; Koca, Doğan; Kucukoner, Mehmet; Gumusay, Ozge; Yildiz, Ramazan; Dayan, Adem; Demir, Lütfiye; Geredeli, Caglayan; Kocer, Murat; Arslan, Ulku Yalcintas; Inal, Ali; Unal, Olcun Umit; Mert, Aslıhan Guven; Bilici, Mehmet; Ozkan, Metin; Elkiran, Emin Tamer; Yaman, Sebnem; Durnalı, Ayse Gok; Suner, Ali; Alici, Suleyman; Tarhan, Mustafa Oktay; Boruban, Cem; Urakci, Zuhat; Buyukberber, Suleyman
Oncology, 01/2012, Letnik: 83, Številka: 3Journal Article
The aim of this study is to determine the relationship between the survival outcomes and biological subtype in breast cancer patients with brain metastases. We retrospectively evaluated clinical data from 422 breast cancer patients with brain metastases between 2001 and 2011 from referral centers in Turkey. The study population was divided into four biological subtypes according to their hormone receptor status and HER2 expression. Systemic treatment prolonged median overall survival (OS) after brain metastases in the entire group (14 vs. 3.2 months, p < 0.001). It also prolonged median OS after brain metastases in the triple negative (7.5 vs. 1.6 months, p = 0.010) and luminal A (14.3 vs. 7.1 months, p = 0.003) subgroups. The median OS for untreated patients, chemotherapy and/or hormonal therapy receiving patients, and chemotherapy and/or hormonal therapy plus targeted therapy receivers was 2, 5.8, and 17.7 months, respectively (p < 0.001), in the HER2-overexpressing subgroup. In the luminal B subgroup, it was 3.7, 5.3, and 15.4 months, respectively (p = 0.003). The use of systemic therapy improves OS after brain metastases in all biological subgroups. Targeted therapies also improve OS after brain metastases in HER2-positive patients. The combined use of targeted therapies and lapatinib are superior to single use and trastuzumab, respectively, in these patients.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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