E-viri
Recenzirano
Odprti dostop
-
Zviran, Asaf; Schulman, Rafael C; Shah, Minita; Hill, Steven T K; Deochand, Sunil; Khamnei, Cole C; Maloney, Dillon; Patel, Kristofer; Liao, Will; Widman, Adam J; Wong, Phillip; Callahan, Margaret K; Ha, Gavin; Reed, Sarah; Rotem, Denisse; Frederick, Dennie; Sharova, Tatyana; Miao, Benchun; Kim, Tommy; Gydush, Greg; Rhoades, Justin; Huang, Kevin Y; Omans, Nathaniel D; Bolan, Patrick O; Lipsky, Andrew H; Ang, Chelston; Malbari, Murtaza; Spinelli, Catherine F; Kazancioglu, Selena; Runnels, Alexi M; Fennessey, Samantha; Stolte, Christian; Gaiti, Federico; Inghirami, Giorgio G; Adalsteinsson, Viktor; Houck-Loomis, Brian; Ishii, Jennifer; Wolchok, Jedd D; Boland, Genevieve; Robine, Nicolas; Altorki, Nasser K; Landau, Dan A
Nature medicine, 07/2020, Letnik: 26, Številka: 7Journal Article
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep targeted sequencing paradigm. We reasoned that breadth may supplant depth of sequencing to overcome the barrier of cfDNA abundance. Whole-genome sequencing (WGS) of cfDNA allowed ultra-sensitive detection, capitalizing on the cumulative signal of thousands of somatic mutations observed in solid malignancies, with TF detection sensitivity as low as 10 . The WGS approach enabled dynamic tumor burden tracking and postoperative residual disease detection, associated with adverse outcome. Thus, we present an orthogonal framework for cfDNA cancer monitoring via genome-wide mutational integration, enabling ultra-sensitive detection, overcoming the limitation of cfDNA abundance and empowering treatment optimization in low-disease-burden oncology care.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.