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HARA, Yuki
Seibutsu Butsuri, 2022, Letnik: 62, Številka: 5Journal Article
The eukaryotic cells can change the size of the cell nucleus, including the genomic DNA, depending on the environment surrounding the cell nucleus. How cells can scale the nuclear size by sensing the environment has remained an enigma for over a century in the field of cell biology. Here, we found a general scaling rule of nuclear size to cell size among eukaryotes and another new aspect for size scaling to the chromatin status inside the nucleus. In this review, I describe the known mechanisms underlying these size scaling characteristics and discuss putative physiological significances for the size scaling.
