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Netea, Mihai G; Domínguez-Andrés, Jorge; Barreiro, Luis B; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A B; van der Meer, Jos W M; Mhlanga, Musa M; Mulder, Willem J M; Riksen, Niels P; Schlitzer, Andreas; Schultze, Joachim L; Stabell Benn, Christine; Sun, Joseph C; Xavier, Ramnik J; Latz, Eicke
Nature reviews. Immunology, 06/2020, Letnik: 20, Številka: 6Journal Article
Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
