The sense of dignity is a multifactorial feeling influenced also by the healthcare context. PDI-IT is a tool that measures this construct, but its psychometric characteristics have not been adequately investigated in patients which are not experiencing and End- Of-Life condition. The aim of this study is to examine the psychometric characteristics of PDI-IT in a group of non-terminal chronic patients and to verify the instrument's invariance with respect to the individual characteristics of patients. A multicentric study was conducted on 421 patients undergoing ambulatory care or hospitalized in specialized medical, surgical and oncological areas. The study of the PDIIT validity in this population was achieved by structural equation (SEM) models; reliability was assessed by Cronbach's Alpha, whereas invariance was studied through multigroup analysis. Findings show an excellent reliability and confirm the monodimensionality of the theoretical structure. After the model optimization interventions, fit indices point out a good data fitting on the reference model. The instrument is invariant with respect to individual characteristics (sex and age) but does not appear to be appropriate for all chronic patients. Although with some cautions about the state of progression of the disease, PDIIT seems to be a valid and reliable tool, useful in measuring the sense of dignity even in populations of chronic patients. Future research should address the development of a short form of the tool.