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van Teijlingen, Nienke H; van Smoorenburg, Marleen Y; Sarrami-Forooshani, Ramin; Zijlstra-Willems, Esther M; van Hamme, John L; Borgdorff, Hanneke; van de Wijgert, Janneke Hhm; van Leeuwen, Elisabeth; van der Post, Joris A M; Strijbis, Karin; Ribeiro, Carla M S; Geijtenbeek, Teunis B H
The Journal of infectious diseases, 2024-Apr-04, 20240404Journal Article
Dysbiosis of the vaginal microbiome poses a serious risk for sexual HIV-1 transmission. Prevotella spp. are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished Prevotella timonensis-enhanced infection. Hence, our study shows that the vaginal microbiome directly affects mucosal CD4+ T cell susceptibility, emphasising importance of vaginal dysbiosis diagnosis and treatment.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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