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Muik, Alexander; Lui, Bonny Gaby; Wallisch, Ann-Kathrin; Bacher, Maren; Mühl, Julia; Reinholz, Jonas; Ozhelvaci, Orkun; Beckmann, Nina; Güimil Garcia, Ramón de la Caridad; Poran, Asaf; Shpyro, Svetlana; Finlayson, Andrew; Cai, Hui; Yang, Qi; Swanson, Kena A; Türeci, Özlem; Şahin, Uğur
Science (American Association for the Advancement of Science), 02/2022, Letnik: 375, Številka: 6581Journal Article
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or Omicron pseudoviruses with sera of 51 participants who received two or three doses of the messenger RNA (mRNA)-based COVID-19 vaccine BNT162b2. After two doses, Omicron-neutralizing titers were reduced >22-fold compared with Wuhan-neutralizing titers. One month after the third vaccine dose, Omicron-neutralizing titers were increased 23-fold relative to their levels after two doses and were similar to levels of Wuhan-neutralizing titers after two doses. The requirement of a third vaccine dose to effectively neutralize Omicron was confirmed with sera from a subset of participants using live SARS-CoV-2. These data suggest that three doses of the mRNA vaccine BNT162b2 may protect against Omicron-mediated COVID-19.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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