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DeBosch, Brian J; Heitmeier, Monique R; Mayer, Allyson L; Higgins, Cassandra B; Crowley, Jan R; Kraft, Thomas E; Chi, Maggie; Newberry, Elizabeth P; Chen, Zhouji; Finck, Brian N; Davidson, Nicholas O; Yarasheski, Kevin E; Hruz, Paul W; Moley, Kelle H
Science signaling, 2016-Feb-23, Letnik: 9, Številka: 416Journal Article
Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to pathological protein aggregation. Despite decades of ubiquitous use as a nutraceutical, preservative, and humectant, its mechanism of action remains elusive. We showed that trehalose inhibited members of the SLC2A (also known as GLUT) family of glucose transporters. Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5'-monophosphate-activated protein kinase)-dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primary murine hepatocyte cultures. Our data indicated that trehalose triggers beneficial cellular autophagy by inhibiting glucose transport.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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