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Cox, Maureen A; Duncan, Gordon S; Lin, Gloria H Y; Steinberg, Benjamin E; Yu, Lisa X; Brenner, Dirk; Buckler, Luke N; Elia, Andrew J; Wakeham, Andrew C; Nieman, Brian; Dominguez-Brauer, Carmen; Elford, Alisha R; Gill, Kyle T; Kubli, Shawn P; Haight, Jillian; Berger, Thorsten; Ohashi, Pamela S; Tracey, Kevin J; Olofsson, Peder S; Mak, Tak W
Science, 02/2019, Letnik: 363, Številka: 6427Journal Article
Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4 and CD8 T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. Deletion of within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic LCMV clone 13 infection. Our results reveal a genetic proof of function for ChAT in T cells during viral infection and identify a pathway of T cell migration that sustains antiviral immunity.
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in: SICRIS
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