E-viri
Recenzirano
Odprti dostop
-
Iacobucci, Ilaria; Wen, Ji; Meggendorfer, Manja; Choi, John K; Shi, Lei; Pounds, Stanley B; Carmichael, Catherine L; Masih, Katherine E; Morris, Sarah M; Lindsley, R Coleman; Janke, Laura J; Alexander, Thomas B; Song, Guangchun; Qu, Chunxu; Li, Yongjin; Payne-Turner, Debbie; Tomizawa, Daisuke; Kiyokawa, Nobutaka; Valentine, Marcus; Valentine, Virginia; Basso, Giuseppe; Locatelli, Franco; Enemark, Eric J; Kham, Shirley K Y; Yeoh, Allen E J; Ma, Xiaotu; Zhou, Xin; Sioson, Edgar; Rusch, Michael; Ries, Rhonda E; Stieglitz, Elliot; Hunger, Stephen P; Wei, Andrew H; To, L Bik; Lewis, Ian D; D'Andrea, Richard J; Kile, Benjamin T; Brown, Anna L; Scott, Hamish S; Hahn, Christopher N; Marlton, Paula; Pei, Deqing; Cheng, Cheng; Loh, Mignon L; Ebert, Benjamin L; Meshinchi, Soheil; Haferlach, Torsten; Mullighan, Charles G
Nature genetics, 04/2019, Letnik: 51, Številka: 4Journal Article
Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of 159 childhood and adult AEL cases with non-AEL myeloid disorders and defined five age-related subgroups with distinct transcriptional profiles: adult, TP53 mutated; NPM1 mutated; KMT2A mutated/rearranged; adult, DDX41 mutated; and pediatric, NUP98 rearranged. Genomic features influenced outcome, with NPM1 mutations and HOXB9 overexpression being associated with a favorable prognosis and TP53, FLT3 or RB1 alterations associated with poor survival. Targetable signaling mutations were present in 45% of cases and included recurrent mutations of ALK and NTRK1, the latter of which drives erythroid leukemogenesis sensitive to TRK inhibition. This genomic landscape of AEL provides the framework for accurate diagnosis and risk stratification of this disease, and the rationale for testing targeted therapies in this high-risk leukemia.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.