Background and Aim With the advancement of percutaneous coronary interventions (PCIs), more patients with diffuse coronary artery disease are referred for coronary artery bypass graft (CABG) surgery. The use of coronary endarterectomy may be useful in such cases. We reviewed our experience with left anterior descending artery endarterectomy as an adjunct to conventional CABG. Methods Between June 2005 and 2011, 58 consecutive patients underwent left anterior descending artery endarterectomy as an adjunct to CABG. These were matched to 58 cases based on age, gender, and Parsonnet score. All data were collected prospectively in a departmental database. Postoperative complications and in‐hospital mortality were analyzed. Survival curves were produced. Results There was one death in the endarterectomy group (1.7%) from liver failure. There was no significant difference in postoperative complications (especially perioperative myocardial infarction) between the two groups with similar hospital mortality. Computed tomography (CT) angiography was performed in 24 patients with endarterectomy (41%), which showed 100% patency of the left internal mammary artery graft to the left anterior descending artery. Survival and freedom from intervention at a mean follow‐up of 4.2 years were similar. Conclusions In patients with diffuse disease, the use of endarterectomy is a safe technique with no increase in short‐term morbidity or mortality. Mid‐term results are similar to nonendarterectomized patients. This technique is useful in patients with diffuse coronary artery disease. doi: 10.1111/jocs.12230 (J Card Surg 2014;29:1‐7)